Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

scientific article

Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1015007427
P356DOI10.1186/1471-2474-15-291
P932PMC publication ID4167280
P698PubMed publication ID25185887
P5875ResearchGate publication ID265342291

P2093author name stringPhilippe Delerive
Florence Namour
Liên Lepescheux
Marielle Auberval
Philippe Clément-Lacroix
Roland Blanqué
Dominique Minet
Céline Cottereaux
Didier Merciris
P2860cites workAtrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophyQ24555065
The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young menQ24561868
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
Selective androgen receptor modulators in preclinical and clinical developmentQ24645579
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3Q24673171
Discovery of diarylhydantoins as new selective androgen receptor modulatorsQ27681990
The steroid and thyroid hormone receptor superfamilyQ27861095
Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonucleiQ28576625
Identification of ubiquitin ligases required for skeletal muscle atrophyQ28582211
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresQ29555845
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophyQ30415879
Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and womenQ33490611
The role of cytokines in cancer cachexiaQ33610662
Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidationQ33633988
The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in miceQ33993411
The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.Q34029187
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.Q34062583
Myocytic androgen receptor controls the strength but not the mass of limb musclesQ34069603
Skeletal muscle loss: cachexia, sarcopenia, and inactivityQ34099406
Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.Q34234465
Metabolic signatures of exercise in human plasmaQ34441396
Hindlimb unloading rodent model: technical aspectsQ34564818
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcriptionQ34575428
Signaling in muscle atrophy and hypertrophyQ34593198
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.Q34609987
Sarcopenia and agingQ35160882
Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopeniaQ36060206
Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and agingQ36130944
Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying ratsQ36347115
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylationQ36534424
The denervated muscle: facts and hypotheses. A historical reviewQ36560326
Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophyQ37600956
Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophyQ38290776
Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcriptionQ38339643
Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-α.Q39681574
Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.Q39938385
Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulationQ39988401
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscleQ40056196
Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complexQ40177208
A model of muscle atrophy using cast immobilization in miceQ40404505
Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligaseQ40494610
IKKbeta/NF-kappaB activation causes severe muscle wasting in miceQ40505119
Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathwayQ40868615
Differential gene expression of muscle-specific ubiquitin ligase MAFbx/Atrogin-1 and MuRF1 in response to immobilization-induced atrophy of slow-twitch and fast-twitch musclesQ42494029
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseasesQ42504415
Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy.Q43037217
Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophyQ43103586
Comparison of the anticatabolic effects of leucine and Ca-β-hydroxy-β-methylbutyrate in experimental models of cancer cachexiaQ43698451
Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophyQ44030256
Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tensionQ44392830
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic controlQ44991663
Oxandrolone enhances hepatic ketogenesis in adult men.Q46363283
Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle.Q51627686
Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice.Q51707697
A novel hindlimb immobilization procedure for studying skeletal muscle atrophy and recovery in mouse.Q51738532
Early change in skeletal muscle protein synthesis after limb immobilization of ratsQ52770657
Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved.Q54377633
FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscleQ56743003
Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix componentsQ60449676
Changes in signalling molecule levels in 10-day hindlimb immobilized rat musclesQ81329948
Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferationQ83905716
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulatorQ84946551
Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in ratsQ85238238
P304page(s)291
P577publication date2014-09-03
P1433published inBMC Musculoskeletal DisordersQ15751716
P1476titleCharacterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
P478volume15

Reverse relations

cites work (P2860)
Q91914220Androgens Drive Sex Biases in Hypothalamic Corticotropin-Releasing Hormone Gene Expression After Adrenalectomy of Mice
Q26744140Cardiac cachexia: hic et nunc
Q39410461Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy
Q49203044Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models
Q90025323Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications