Prognostic implications of chromosome 17 abnormalities in the context of monosomal karyotype in patients with acute myeloid leukemia and complex cytogenetics

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Prognostic implications of chromosome 17 abnormalities in the context of monosomal karyotype in patients with acute myeloid leukemia and complex cytogenetics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CLML.2013.07.009
P932PMC publication ID4167660
P698PubMed publication ID24461514

P50authorFarhad RavandiQ40614280
Jorge Eduardo CortesQ60320900
Hagop KantarjianQ60394812
Gautam BorthakurQ66370731
Tapan KadiaQ66370733
Alfonso Quintas-CardamaQ66370882
Guillermo Garcia-ManeroQ66385413
Michael J. KeatingQ66429598
Graciela M Nogueras-GonzalezQ87214855
Naveen PemmarajuQ87733857
Naval DaverQ88327648
Lynne V AbruzzoQ96099267
Aziz NazhaQ114427910
P2093author name stringVijaya R Bhatt
P2860cites workThe 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changesQ22299206
Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patientsQ31892904
Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53.Q33397876
The prognostic value of cytogenetics is reinforced by the kind of induction/consolidation therapy in influencing the outcome of acute myeloid leukemia--analysis of 848 patientsQ34288377
Cytogenetics in acute leukemiaQ34304230
Cytarabine dose for acute myeloid leukemiaQ34627648
Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotypeQ36808186
Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experienceQ37006786
Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemiaQ37635209
17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situQ38503283
The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemiaQ40009452
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid LeukemiaQ40543180
Mutation of the p53 gene in human acute myelogenous leukemiaQ41688717
Clofarabine combinations as acute myeloid leukemia salvage therapyQ42048738
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.Q43102402
Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemiaQ46169540
The impact of abn(17p) and monosomy -5/del(5q) on the prognostic value of the monosomal karyotype in acute myeloid leukemiaQ46189022
Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q-.Q46521483
Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia.Q46735727
Long-term analysis of the IFM 99 trials for myeloma: cytogenetic abnormalities [t(4;14), del(17p), 1q gains] play a major role in defining long-term survival.Q47826998
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis.Q50629545
Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy.Q55067694
Chronic lymphocytic leukaemia with 17p deletion: a retrospective analysis of prognostic factors and therapy resultsQ59413209
Mutations of the P53 gene in acute myeloid leukaemiaQ68077839
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotypeQ81402320
Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotypeQ81769874
Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategiesQ82568634
Monosomal karyotype in acute myeloid leukemia predicts adverse treatment outcome and associates with high functional multidrug resistance activityQ82696653
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcomeQ83080803
Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotypeQ83154836
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectkaryotypeQ189967
acute myeloid leukemiaQ264118
P304page(s)163-171
P577publication date2014-01-22
P1433published inClinical Lymphoma, Myeloma & LeukemiaQ5133774
P1476titlePrognostic implications of chromosome 17 abnormalities in the context of monosomal karyotype in patients with acute myeloid leukemia and complex cytogenetics
P478volume14

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cites work (P2860)
Q52953786Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype - retrospective analysis of Polish Adult Leukemia Group (PALG).
Q57058970Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care
Q36474066Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies
Q38760193Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials

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