Small bowel review: Normal physiology, part 1.

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Small bowel review: Normal physiology, part 1. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1036457006
P356DOI10.1023/A:1024719925058
P698PubMed publication ID12924651

P50authorSéverine VermeireQ30247983
P2093author name stringAlan B R Thomson
M Tom Clandinin
Ben K A Thomson
Claudiu Iordache
Gary Wild
Laurie Drozdowski
P2860cites workIntestinal plasma membrane calcium pump protein and its induction by 1,25(OH)(2)D(3) decrease with ageQ78009154
Ion transport across the normal and CF neonatal murine intestineQ78009190
Expression of AE2 anion exchanger in mouse intestineQ78117268
Cytoplasmic transport of fatty acids in rat enterocytes: role of binding to fatty acid-binding proteinQ78117287
Blood flow-dependent prostaglandin f(2alpha) regulates intestinal glucose uptake from the bloodQ78117293
A novel mammalian iron-regulated protein involved in intracellular iron metabolismQ22253435
Factors involved in the duodenal expression of the human calbindin-D9k geneQ24531565
Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestineQ28137924
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulationQ28140006
EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell lineQ28142080
Identification of the major intestinal fatty acid transport proteinQ28145772
Molecular medicine of TFF-peptides: from gut to brainQ28200285
Intestinal bile acid transport: biology, physiology, and pathophysiologyQ28200862
Epithelial calcium transporter expression in human duodenumQ28201525
Mucosal pathophysiology and inflammatory changes in the late phase of the intestinal allergic reaction in the ratQ28346165
Role of duodenal lipid and cholecystokinin A receptors in the pathophysiology of functional dyspepsiaQ28348673
Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestineQ28361841
Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytesQ28362820
Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestineQ28576216
cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1Q28586773
Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient dietQ43545235
SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cellsQ43545250
In vivo absorption of medium-chain fatty acids by the rat colon exceeds that of short-chain fatty acidsQ43552265
ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism.Q43552272
Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.Q43568305
Desensitization of ileal vagal receptors by short-chain fatty acids in pigsQ43568330
A Na+-dependent D-mannose transporter in the apical membrane of chicken small intestine epithelial cellsQ43569077
Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cellsQ43575424
Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overloadQ43582807
In vivo measurement of intestinal absorption using 3-0 methylglucose in short bowel syndromeQ43592814
Effect of lipopolysaccharide on small intestinal L-leucine transport in rabbit.Q43600155
Inhibition of intestinal cholesterol absorption by surfomer (alpha-olefin maleic acid) affects hepatic cholesterol synthesis and low density lipoprotein transport in hamsters fed a fat-enriched dietQ43602859
The intestine expresses pancreatic triacylglycerol lipase: regulation by dietary lipidQ43607594
Prolactin directly stimulates transcellular active calcium transport in the duodenum of female ratsQ43639238
EGF and TGF stimulate proabsorption of glucose and electrolytes by Na+/glucose cotransporter in awake canine modelQ43709302
Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathwaysQ43722805
Stroking human jejunal mucosa induces 5-HT release and Cl- secretion via afferent neurons and 5-HT4 receptorsQ44864003
Recombinant Norwalk virus-like particles given orally to volunteers: phase I studyQ45748767
Peroral gene therapy of lactose intolerance using an adeno-associated virus vectorQ45753463
Adenovirus-mediated human pancreatic lipase gene transfer to rat bile: gene therapy of fat malabsorptionQ45871980
Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liverQ46190468
Anderson's disease: exclusion of apolipoprotein and intracellular lipid transport genesQ46298681
Transcobalamin II synthesized in the intestinal villi facilitates transfer of cobalamin to the portal bloodQ46519074
Fragmentation pattern of mucins in normal and diseased gastric mucosae: a glycoprotein fractionates with gastric mucins purified from mucosal scrapings of cancer and peptic ulcer patientsQ46922526
Hypoxia and CYP1A1 induction-dependent regulation of proteins involved in glucose utilization in Caco-2 cellsQ47717843
Regulation of intestinal apolipoprotein B mRNA editing levels by a zinc-deficient diet and cDNA cloning of editing protein in hamstersQ47834845
The effects of intestinal infusion of long-chain fatty acids on food intake in humansQ48698506
Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamusQ48923550
The human Na+–glucose cotransporter is a molecular water pumpQ48939861
Vitamin A deficiency reduces uptake of beta-carotene by brush border membrane vesicles but does not alter intestinal retinyl ester hydrolase activity in the rat.Q50131198
Antisecretory effect of peptide YY through neural receptors in the rat jejunum in vitroQ51439285
Effect of splanchnectomy on jejunal motility and fos expression in brain stem after intestinal anaphylaxis in rat.Q51552989
Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fastQ51562729
Effect of lactitol on blood ammonia response to oral glutamine challenge in cirrhotic patients: evidence for an effect of nonabsorbable disaccharides on small intestine ammonia generationQ52030996
Developmental expression of PEPT1 and PEPT2 in rat small intestine, colon, and kidneyQ52134695
Immunological analysis of beta-thalassemic mouse intestinal proteins reveals up-regulation of sucrase-isomaltase in response to iron overloadQ52534859
NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice.Q52536014
Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in miceQ52536708
Galactose transport inhibition by cytochalasin E in rat intestine in vitroQ52536783
The intestinal fatty acid binding protein is not essential for dietary fat absorption in miceQ52541214
Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosisQ52542851
Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergyQ52844746
Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cellsQ54041692
Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestineQ54131894
GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosisQ56835462
Intestinal Macromolecule Absorption in the Fetal Pig after Infusion of Colostrum in UteroQ56835478
Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in miceQ64380231
Transport characteristics of peptides and peptidomimetics: I. N-methylated peptides as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.Q64975610
Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1Q73004002
Transport of procainamide via H(+)/tertiary amine antiport system in rabbit intestinal brush-border membraneQ73004022
Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across DeltaF508 murine intestinesQ77813258
Lactase-phlorizin hydrolase and sucrase-isomaltase genes are expressed differently along the villus-crypt axis of rat jejunumQ77835001
Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Q28609224
The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test mealsQ28623957
The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alphaQ28678556
Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in ratsQ30321005
Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1.Q30789833
Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat.Q30911748
Effects of isoprostanes and prostanoids on porcine small intestineQ31842182
Glutamine ameliorates mechanical obstruction-induced intestinal injuryQ31852510
The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterizationQ31881662
Chemistry of metal-bound anion radicals. A family of mono- and bis(azopyridine) chelates of bivalent rutheniumQ31985554
Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topographyQ32031014
Involvement of PI 3-kinase in IGF-I stimulation of jejunal Na+-K+-ATPase activity and nutrient absorptionQ32031073
Sucrase-isomaltase is an adenosine 3',5'-cyclic monophosphate-dependent epithelial chloride channelQ32033679
Enhancement of jejunal absorption of conjugated bile acid by neurotensin in ratsQ32033755
Influence of fatty alcohol and other fatty acid derivatives on fatty acid uptake into rat intestinal epithelial cellsQ32051256
Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transportersQ33178888
Ibuprofen augments gastrointestinal symptoms in lactose maldigesters during a lactose tolerance testQ33420984
Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolaseQ33423163
Intestinal fructose absorption: clinical and molecular aspects.Q33594606
Lessons on renal physiology from transgenic mice lacking aquaporin water channelsQ33610689
The regulation of mineral absorption in the gastrointestinal tractQ33644510
Plasticity of the gastrointestinal epithelium: the M cell paradigm and opportunism of pathogenic microorganismsQ33669596
Intestinal peptide transport systems and oral drug availabilityQ33738294
Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosaQ33749166
Olestra formulation and the gastrointestinal tractQ33755764
Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimerQ33876356
Carbohydrate malabsorption syndromes and early signs of mental depression in femalesQ33915393
Developmental aspects of lipid and lipoprotein synthesis and secretion in human gut.Q33924105
Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.Q33937934
One-hundred years of inquiry: the mechanism of glucose absorption in the intestineQ33938835
Intracellular transport of bile acidsQ33944790
The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metalsQ33968651
Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular riskQ33989682
Genetic defects of intracellular-membrane transportQ34057852
Murine CFTR channel and its role in regulatory volume decrease of small intestine cryptsQ34110115
Haemochromatosis: iron still mattersQ34309845
Congenital sucrase-isomaltase deficiency arising from cleavage and secretion of a mutant form of the enzymeQ35126557
Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigsQ35354798
Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overloadQ35358811
Modification of small bowel mechanosensitivity by intestinal fatQ35363451
Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitorQ35557602
Adaptation of intestinal production of apolipoprotein A-IV during chronic feeding of lipidQ38494034
Nucleotide and nucleoside supplementation may morphologically promote the differentiation of human caco-2 cells.Q39120812
Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acidsQ39513759
Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrheaQ40431773
Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cellsQ40793521
Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytesQ40806219
Sulfate and chloride transport in Caco-2 cells: differential regulation by thyroxine and the possible role of DRA geneQ40820501
H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cellsQ40851744
Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestineQ40856210
Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptorQ40857332
alpha(2)-adrenergic receptors stimulate oligopeptide transport in a human intestinal cell lineQ40867841
Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2.Q40869146
Factors affecting antigen uptake by human intestinal epithelial cell linesQ40870430
Human intestinal epithelial cells express a novel receptor for IgA.Q40881638
Effects of intestinal fatty acid-binding protein overexpression on fatty acid metabolism in Caco-2 cells.Q40907272
Transport of human growth hormone across Caco-2 cells with novel delivery agents: evidence for P-glycoprotein involvementQ40923437
Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2.Q40949441
Characterization of the inhibitory effect of boiled rice on intestinal chloride secretion in guinea pig crypt cellsQ40951591
Role for IL-4 in macromolecular transport across human intestinal epitheliumQ40954093
NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation.Q40961398
Regulation of Na+/glucose cotransportersQ41363600
No metal cofactor in orotidine 5'-monophosphate decarboxylaseQ41666258
Saturable stimulation of fatty acid transport through model cytoplasm by soluble binding proteinQ41679621
Lymphatic absorption of structured triglycerides vs. physical mix in a rat model of fat malabsorptionQ41684897
Transport of thiamine in human intestine: mechanism and regulation in intestinal epithelial cell model Caco-2.Q41695427
Role of Na+-glucose cotransport in jejunal meal-induced absorptionQ41722250
Role of hepatocyte nuclear factor 1alpha and 1beta in the transcriptional regulation of human dipeptidyl peptidase IV during differentiation of Caco-2 cellsQ41726672
Structure and dynamics of the fatty acid binding cavity in apo rat intestinal fatty acid binding proteinQ41775313
Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1 alphaQ41807148
Acute increase, stimulated by prostaglandin E2, in glucose absorption via the sodium dependent glucose transporter-1 in rat intestine.Q41864303
Effect of proinflammatory interleukins on jejunal nutrient transportQ42259565
Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complexQ42474856
Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestineQ42477450
Regulation of intestinal epithelial brush border Na(+)/H(+) exchanger isoforms, NHE2 and NHE3, in C2bbe cellsQ42477511
Effect of a dietary nonionic surfactant on small intestinal nutrient transportQ42477656
Isolated deficient alpha6beta4 integrin expression in the gut associated with intractable diarrheaQ42478365
The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membraneQ42997228
Effect of vasoactive intestinal polypeptide (VIP) antagonism on rat jejunal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxinsQ43086269
Improvement of intestinal absorption of peptides: adsorption of B1-Phe monoglucosylated insulin to rat intestinal brush-border membrane vesiclesQ43506549
Role of pre-epithelial "unstirred" layers in absorption of nutrients from the human jejunumQ43541076
Expression of apolipoprotein B-100 in isolated human small intestine epitheliumQ73028123
K(+) secretion in rat distal jejunumQ73030297
Essential fatty acid deficiency affects the fatty acid composition of the rat small intestinal and colonic mucosa differentlyQ73039534
A fluorescent cholesterol analog traces cholesterol absorption in hamsters and is esterified in vivo and in vitroQ73045933
Increased dietary triacylglycerol markedly enhances the ability of isolated rabbit enterocytes to secrete chylomicrons: an effect related to dietary fatty acid compositionQ73045954
Regulation of small intestinal Na-P(i) type IIb cotransporter by dietary phosphate intakeQ73070911
Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjectsQ73101044
Differential expression of ileal Na(+)/H(+) exchanger isoforms after enterectomyQ73114697
5-HT(3) and histamine H(1) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in ratsQ73130771
Amount and fate of egg protein escaping assimilation in the small intestine of humansQ73188623
Marked increase of guanylin secretion in response to salt loading in the rat small intestineQ73188634
Stimulation of jejunal synthesis of apolipoprotein A-IV by ileal lipid infusion is blocked by vagotomyQ73188665
Diagnosis of lipid malabsorption in patients with chronic pancreatitis: a new indirect test using postprandial plasma apolipoprotein B-48Q73194440
Transport of N(G)-nitro-L-arginine across intestinal brush border membranes by Na+ -dependent and Na+-independent amino acid transportersQ73203989
Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligationQ73230231
Nutritional regulation of nucleoside transporter expression in rat small intestineQ73288674
Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesiclesQ73308098
AT motif binding factor 1-A (ATBF1-A) negatively regulates transcription of the aminopeptidase N gene in the crypt-villus axis of small intestineQ73329988
Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporterQ73378121
Riboflavin uptake by human-derived colonic epithelial NCM460 cellsQ73426616
Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditionsQ73442193
Divalent metals inhibit and lactose stimulates zinc transport across brush border membrane vesicles from pigletsQ73448643
Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransportQ73533349
Immunolocalization, ontogeny, and regulation of microsomal triglyceride transfer protein in human fetal intestineQ73629879
Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses is not common in normal adultsQ73641782
Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patchesQ73666765
The adherent gastrointestinal mucus gel layer: thickness and physical state in vivoQ73727591
Increased zinc absorption but not secretion in the small intestine of metallothionein-null miceQ73789766
Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrheaQ73792770
Contribution of villous atrophy to reduced intestinal maltase in infants with malnutritionQ73806257
Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade ratsQ73907316
Iron-ascorbate alters the efficiency of Caco-2 cells to assemble and secrete lipoproteinsQ74013612
Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporterQ74026363
A target for cholesterol absorption inhibitors in the enterocyte brush border membraneQ74026369
Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-IQ74070938
Lymphatic absorption of fatty acids and cholesterol in the neonatal ratQ74070945
Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestineQ74244343
Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemiaQ74270504
Protein metabolism in the small intestine during cancer cachexia and chemotherapy in miceQ74314881
Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4Q74315876
Uptake of barbituric acid derivatives in small intestinal brush border membrane vesicles from retinyl palmitate-treated ratsQ74319181
CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivoQ74482469
Multiplicity of the H+-dependent transport mechanism of dipeptide and anionic beta-lactam antibiotic ceftibuten in rat intestinal brush-border membraneQ74624534
Transcriptional regulation of pig lactase-phlorizin hydrolase: involvement of HNF-1 and FREACsQ74637105
Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorptionQ74648041
Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco‐2 cellsQ77086936
PKC regulates turnover rate of rabbit intestinal Na+-glucose transporter expressed in COS-7 cellsQ77755484
Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cellsQ77755493
P433issue8
P304page(s)1546-1564
P577publication date2003-08-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleSmall bowel review: Normal physiology, part 1
P478volume48

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cites work (P2860)
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Q33909384The human jejunum has an endogenous microbiota that differs from those in the oral cavity and colon

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