Viperin: a radical response to viral infection

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Viperin: a radical response to viral infection is …
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scholarly articleQ13442814

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P356DOI10.1515/BMC-2011-0057
P932PMC publication ID4171118
P698PubMed publication ID25254077

P50authorJoan B. BroderickQ28051432
P2093author name stringKaitlin S Duschene
P2860cites workThe lipid droplet is an important organelle for hepatitis C virus productionQ28131709
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IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene inductionQ28509760
Best5: a novel interferon-inducible gene expressed during bone formationQ28566178
Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetaseQ28570344
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cellsQ28594284
Membrane curvature and mechanisms of dynamic cell membrane remodellingQ29617321
Neutrophils and immunity: challenges and opportunitiesQ29617616
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An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5AQ29620628
Human cytomegalovirus UL99-encoded pp28 is required for the cytoplasmic envelopment of tegument-associated capsids.Q30333473
Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual raftsQ30441859
Human cytomegalovirus UL37 immediate-early regulatory proteins traffic through the secretory apparatus and to mitochondriaQ30881356
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirusQ24292060
Activities of IRF-1Q24292304
The antiviral protein viperin is a radical SAM enzymeQ24300516
Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivityQ24300637
TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5Q24303885
Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAsQ24311713
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effectorQ24316159
The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretionQ24324760
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33Q24338873
Antiviral actions of interferonsQ24550676
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raftQ24600344
Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methodsQ24616026
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5AQ24632380
Lipid droplets at a glanceQ24646389
The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helixQ24655264
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virusQ24658111
How neutrophils kill microbesQ24672245
Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA ReplicationQ27473477
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage dropletsQ27481061
Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and PatientsQ27482207
The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected CellsQ27487126
Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzymeQ27652499
Protein structure prediction on the Web: a case study using the Phyre serverQ27860664
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Influenza viruses select ordered lipid domains during budding from the plasma membraneQ40980312
Herpesvirus in atherosclerosis and thrombosis: etiologic agents or ubiquitous bystanders?Q41726544
Control of adenosylmethionine-dependent radical generation in biotin synthase: a kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB.Q41853708
Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infectionQ41855580
Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsiQ42635098
Role of lipid rafts in virus replicationQ45424163
Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamilyQ46461917
Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogensQ48223710
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Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cellsQ59394046
The Radical SAM SuperfamilyQ63351978
Differential ability of human blood monocyte subsets to release various cytokinesQ70081347
Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12Q71815198
Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme. Molecular properties of the holoenzyme formQ74230768
The contribution of inducible nitric oxide and cytomegalovirus to the stability of complex carotid plaqueQ77962064
Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1Q79929205
Gene expression profiles during in vivo human rhinovirus infection: insights into the host responseQ81704065
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agentsQ81742757
Formation of stacked ER cisternae by low affinity protein interactionsQ31018281
Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzymeQ33520171
vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA familyQ33652783
Accumulation of virion tegument and envelope proteins in a stable cytoplasmic compartment during human cytomegalovirus replication: characterization of a potential site of virus assemblyQ33796667
The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon?Q33921313
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Do pathogens accelerate atherosclerosis?Q34389205
A general amphipathic alpha-helical motif for sensing membrane curvature.Q34601480
vMIA, a viral inhibitor of apoptosis targeting mitochondriaQ34648862
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid raftsQ34713956
Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infectionQ35237571
Mitochondrial beta-oxidationQ35631612
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High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosisQ35811381
The human cytomegalovirus UL37 immediate-early regulatory protein is an integral membrane N-glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatusQ35870987
Structure and function of radical SAM enzymes.Q35902744
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Wrapping things up about virus RNA replicationQ36271058
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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.Q36544465
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Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon responseQ37568171
Amphipathic helices and membrane curvatureQ37616695
Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.Q37627335
Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domainQ38297276
Envelopment of human cytomegalovirus occurs by budding into Golgi-derived vacuole compartments positive for gB, Rab 3, trans-golgi network 46, and mannosidase II.Q39733632
Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transportQ39868792
An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replicationQ40162016
Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteinsQ40358059
Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expressionQ40499099
Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways.Q40847997
P433issue3
P304page(s)255-266
P577publication date2012-06-01
P1433published inBiomolecular conceptsQ26853930
P1476titleViperin: a radical response to viral infection
P478volume3

Reverse relations

cites work (P2860)
Q33851840Emerging themes in radical SAM chemistry
Q36340422Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats.
Q37727698Radical S-adenosylmethionine enzymes

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