αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling.

scientific article

αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.EXER.2010.08.006
P932PMC publication ID2962712
P698PubMed publication ID20709056
P5875ResearchGate publication ID45649833

P50authorUsha P. AndleyQ55344421
P2093author name stringA Sue Menko
P2860cites workCell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21qQ24295954
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAAQ24310410
Cloning, expression, and chaperone-like activity of human alphaA-crystallinQ24323875
Expression of the murine alpha B-crystallin gene is not restricted to the lensQ24633848
A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cellsQ28185462
Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometryQ28256123
Cell adhesion: the molecular basis of tissue architecture and morphogenesisQ28276573
The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stressQ28504935
The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrinQ28508336
Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallinQ28511428
alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissuesQ28568273
Alpha-crystallin expression affects microtubule assembly and prevents their aggregationQ28585733
Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout miceQ28588054
Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouseQ28588245
Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell deathQ28591145
Regulation of cadherin-mediated adhesion in morphogenesisQ29614940
Alpha-crystallin can function as a molecular chaperoneQ29618672
Changes in adhesion complexes define stages in the differentiation of lens fiber cells.Q30655686
The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosisQ30784416
The function of alpha-crystallin in visionQ33874602
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activationQ33938470
Interaction between alphaB-crystallin and the human 20S proteasomal subunit C8/alpha7.Q33945821
Characterization of alpha-crystallin-plasma membrane bindingQ33989106
alpha-Crystallin chaperone-like activity and membrane binding in age-related cataractsQ33989116
Crystallins in the eye: Function and pathologyQ34573270
sHsp-phosphorylation: enzymes, signaling pathways and functional implicationsQ34573356
Small stress proteins: novel negative modulators of apoptosis induced independently of reactive oxygen species.Q34573367
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.Q34704564
Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animalsQ36235809
Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunitQ36383304
The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosisQ36700284
Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.Q36805868
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastomaQ36825199
Heat shock genes - integrating cell survival and deathQ36834709
AlphaB-crystallin selectively targets intermediate filament proteins during thermal stressQ38326485
Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeletonQ40231216
Lens differentiation in vertebrates. A review of cellular and molecular featuresQ40320035
Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissuesQ40567118
Human bcl-2 gene attenuates the ability of rabbit lens epithelial cells against H2O2-induced apoptosis through down-regulation of the alpha B-crystallin geneQ40781735
Chaperone activity of alpha-crystallins modulates intermediate filament assembly.Q40790972
Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells.Q40857765
Expression of growth control and differentiation genes in human lens epithelial cells with extended life spanQ41026439
Propagation and immortalization of human lens epithelial cells in culture.Q41462261
Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cellsQ42022296
Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK.Q42167085
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survivalQ42253816
Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cellsQ42468382
Beta 1 integrins in epithelial tissues: a unique distribution in the lensQ42477665
The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturationQ43556597
alphaB-crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting caspase-3 activationQ43673843
Systematic analysis of E-, N- and P-cadherin expression in mouse eye development.Q44070493
Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinasesQ44119989
AlphaB-crystallin regulates intermediate filament organization in situQ44164334
CNS integrins switch growth factor signalling to promote target-dependent survivalQ44179357
A signaling role for the uncleaved form of alpha 6 integrin in differentiating lens fiber cellsQ44218948
The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiationQ46435017
alpha-Crystallin localizes to the leading edges of migrating lens epithelial cellsQ46476357
Stabilization of integrin-linked kinase by binding to Hsp90.Q46481184
Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.Q46612862
Molecular chaperones and the stress of oncogenesisQ47785215
N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro.Q52169646
alpha6 Integrin is regulated with lens cell differentiation by linkage to the cytoskeleton and isoform switching.Q52176606
Mechanism of Src kinase induction of cortical cataract following exposure to stress: destabilization of cell-cell junctions.Q54014933
HSP27 inhibits cytochrome c-dependent activation of procaspase-9.Q54073678
6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- B-dependent resistance to apoptosis in 3D mammary aciniQ57980146
Involvement of the N-terminal region in alpha-crystallin-lens membrane recognitionQ68036635
Alpha crystallin from human cataractous vs. normal lenses: change in binding to lens membraneQ68716188
Specificity of alpha crystallin binding to the lens membraneQ68801770
Differential expression of N- and B-cadherin during lens developmentQ73006516
Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instabilityQ73375634
The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitinationQ78618803
Interactions between important regulatory proteins and human alphaB crystallinQ80289371
P433issue5
P304page(s)640-651
P577publication date2010-08-13
P1433published inExperimental Eye ResearchQ15754753
P1476titleαA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling
P478volume91

Reverse relations

cites work (P2860)
Q90182577Creatine kinase/α-crystallin interaction functions in cataract development
Q35919805Mutation analysis of two families with inherited congenital cataracts
Q36319594Novel roles for α-crystallins in retinal function and disease
Q37953906ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.
Q84127211α-Crystallin promotes rat axonal regeneration through regulation of RhoA/rock/cofilin/MLC signaling pathways
Q37583421α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.

Search more.