Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure

scientific article published on August 18, 2010

Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2010.08.011
P953full work available at URLhttps://europepmc.org/articles/pmc2963662?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20727364/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20727364/pdf/?tool=EBI
https://europepmc.org/articles/PMC2963662
https://europepmc.org/articles/PMC2963662?pdf=render
https://doi.org/10.1016/j.neuropharm.2010.08.011
https://api.elsevier.com/content/article/PII:S0028390810002108?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0028390810002108?httpAccept=text/xml
P932PMC publication ID2963662
P698PubMed publication ID20727364
P5875ResearchGate publication ID45797838

P50authorWerner SieghartQ54281325
Samarpan MajumderQ104135129
P2093author name stringHao Zhou
James M. Cook
Xiaohui He
Zhi-Jian Wang
Jianming Yu
Shengming Huang
Joachim Ramerstorfer
Roman Furtmüller
Rahul V. Edwankar
Bryan L. Roth
Edward M. Johnson
Bradford D. Fischer
Stephanie C. Licata
James K. Rowlett
P2860cites workAnti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptorsQ46868521
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.Q48560999
Molecular and neuronal substrate for the selective attenuation of anxiety.Q51376038
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.Q51434685
Effects of different classes of partial benzodiazepine agonists on punished and unpunished responding in pigeons.Q52175303
International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateQ24608968
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in ratsQ24644631
Type I and type II GABAA-benzodiazepine receptors produced in transfected cellsQ28342945
Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsQ28594296
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primatesQ30854476
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.Q33902217
GABA(A) receptor subtypes: dissecting their pharmacological functionsQ34204921
Benzodiazepine self-administration in humans and laboratory animals--implications for problems of long-term use and abuse.Q34449375
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.Q34453763
The neurobiology and control of anxious statesQ35202929
Overview of diagnosis and drug treatments of anxiety disordersQ35993517
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat modelsQ37164117
Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptorsQ38325476
Comparison of drug effects on responding punished by pressurized air or electric shock delivery in squirrel monkeys: pentobarbital, chlordiazepoxide, d-amphetamine and cocaineQ39661025
Which GABAA-receptor subtypes really occur in the brain?Q41003268
Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydQ45248663
Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbituratesQ46723604
P433issue7-8
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)612-618
P577publication date2010-08-18
P1433published inNeuropharmacologyQ15332439
P1476titleAnxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
P478volume59

Reverse relations

cites work (P2860)
Q26774869A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model
Q35158189A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia
Q45056140Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats
Q30429949Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected].
Q36793359Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype
Q36421449Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis
Q30405706Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model
Q42756275Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells
Q34989652Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
Q88692610Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors
Q37718469Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states
Q34540561Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit
Q88548094Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys
Q38820230Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors
Q92300503GABAA Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators
Q30421260GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism
Q36592958HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain
Q98287932Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain
Q38924891Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024.
Q36775238Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys
Q40165591Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.
Q36487793Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes
Q30647960Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling
Q37718608Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects
Q40819756Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy
Q98288525Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression
Q27026637The role of α5 GABAA receptor agonists in the treatment of cognitive deficits in schizophrenia
Q36128349Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference
Q61449922Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

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