Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy

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Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...735353S
P356DOI10.1371/JOURNAL.PONE.0035353
P932PMC publication ID3325934
P698PubMed publication ID22514734
P5875ResearchGate publication ID224709297

P50authorSachio MorimotoQ40010169
P2093author name stringNagomi Kurebayashi
Takashi Murayama
Takashi Sakurai
Takao Shioya
Fuminori Odagiri
Hiroyuki Daida
Takeshi Suzuki
Yuji Nakazato
Hiroto Nishizawa
Akihito Chugun
Masami Sugihara
P2860cites workLarge-scale analysis of ion channel gene expression in the mouse heart during perinatal development.Q52006604
Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice.Q52046408
Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes.Q52132199
Idiopathic Dilated CardiomyopathyQ56987016
Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardiaQ73505422
Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrinQ73842618
Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarctionQ77393695
Knock-in mouse model of dilated cardiomyopathy caused by troponin mutationQ80447572
Postnatal development has a marked effect on ventricular repolarization in miceQ80736288
Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunctionQ81492019
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Q24301857
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and functionQ24634087
Causes of abnormal Ca2+ transients in Guinea pig pathophysiological ventricular muscle revealed by Ca2+ and action potential imaging at cellular levelQ27342134
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathyQ28139470
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Cellular basis of triggered arrhythmias in heart failureQ28251279
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradientQ28587676
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient miceQ28591672
The Genetic Basis for CardiomyopathyQ29300961
Behavior of Ca(2+) waves in multicellular preparations from guinea pig ventricleQ33205833
Aberrant cell-to-cell coupling in Ca2+-overloaded guinea pig ventricular musclesQ33326801
Electrophysiological remodeling in hypertrophy and heart failureQ33758963
Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.Q33894656
Recurrent and founder mutations in the Netherlands: mutation p.K217del in troponin T2, causing dilated cardiomyopathyQ34195576
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heartQ34361080
Mechanical effects on arrhythmogenesis: from pipette to patient.Q35121854
Electrophysiological changes in heart failure and their relationship to arrhythmogenesisQ35635094
Long QT syndrome: reduced repolarization reserve and the genetic linkQ36335258
Sarcomeric protein mutations in dilated cardiomyopathyQ36369921
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.Q36788875
Sarcomeric proteins and inherited cardiomyopathies.Q37023249
Animal models of arrhythmogenic cardiomyopathyQ37628322
Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes.Q37714017
What explains black-white differences in survival in idiopathic dilated cardiomyopathy? The Washington, DC, Dilated Cardiomyopathy StudyQ38954596
Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation.Q40804479
The natural history of idiopathic dilated cardiomyopathyQ40854386
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.Q41947515
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease.Q42160059
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathyQ43068905
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout miceQ43562608
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsivenessQ43633756
SR calcium handling and calcium after-transients in a rabbit model of heart failureQ44385086
Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse heartsQ44767110
Functional properties of K+ currents in adult mouse ventricular myocytesQ44991716
Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: role of increased fibrosis in the generation of reentryQ45307190
Electrical remodeling in a transgenic mouse model of alpha1B-adrenergic receptor overexpression.Q45968267
Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.Q45991846
A simple technique for isolating healthy heart cells from mouse modelsQ46916697
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventriclesQ47350584
Hallmarks of ion channel gene expression in end-stage heart failureQ48206560
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectheart failureQ181754
P304page(s)e35353
P577publication date2012-04-13
P1433published inPLOS OneQ564954
P1476titleMultistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy
P478volume7

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cites work (P2860)
Q35903061Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease
Q28066019Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models
Q45714731Development of heart failure is independent of K+ channel-interacting protein 2 expression
Q35202392Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice
Q50055567Hyperoxia-induced cardiotoxicity and ventricular remodeling in type-II diabetes mice
Q44702733Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice
Q34388593Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes
Q91885085Reduced hybrid/complex N-glycosylation disrupts cardiac electrical signaling and calcium handling in a model of dilated cardiomyopathy
Q36730574The link between abnormal calcium handling and electrical instability in acquired long QT syndrome--Does calcium precipitate arrhythmic storms?
Q34373955The potential role of Kv4.3 K+ channel in heart hypertrophy
Q34576662Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model

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