The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein

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The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002688
P932PMC publication ID3349754
P698PubMed publication ID22589720
P5875ResearchGate publication ID224966919

P50authorDan M GranoffQ48255905
P2093author name stringPeter T Beernink
Sanjay Ram
Rolando Pajon
Jutamas Shaughnessy
Emily M Braga
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An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroupsQ84729221
Meningococcal factor H-binding protein variants expressed by epidemic capsular group A, W-135, and X strains from AfricaQ34039044
Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strainsQ34185172
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Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen.Q34594327
Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal diseaseQ34729067
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A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccinationQ34993283
Immunogenicity of a meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and over-expressed factor H binding protein in infant rhesus monkeys.Q35043042
A critical threshold of meningococcal factor H binding protein expression is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccinesQ35066132
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Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870Q36370598
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistanceQ36470692
Protective antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed genome-derived neisserial antigen 1870Q36638451
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Vaccination against meningococcal disease in Europe: review and recommendations for the use of conjugate vaccines.Q36683979
Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccinesQ36710765
Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit seraQ37075472
Meningococcal outer membrane vesicle vaccines derived from mutant strains engineered to express factor H binding proteins from antigenic variant groups 1 and 2Q37099232
Vaccine potential of the Neisseria meningitidis 2086 lipoproteinQ37115883
Bactericidal antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed factor H-binding protein and genetically attenuated endotoxinQ37126987
Serogroup B meningococcal vaccines-an unfinished storyQ37683962
A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.Q38478418
Changes in Neisseria meningitidis disease epidemiology in the United States, 1998-2007: implications for prevention of meningococcal diseaseQ39920363
Teasing apart structural determinants of 'toxicity' and 'adjuvanticity': implications for meningococcal vaccine developmentQ40513524
Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccineQ40564309
Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesisQ48761076
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P304page(s)e1002688
P577publication date2012-05-10
P1433published inPLOS PathogensQ283209
P1476titleThe effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein
P478volume8

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cites work (P2860)
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