The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila

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The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila is …
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scholarly articleQ13442814

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P819ADS bibcode2006PNAS..103..660G
P356DOI10.1073/PNAS.0506182103
P932PMC publication ID1334640
P698PubMed publication ID16407137
P5875ResearchGate publication ID7365185

P2093author name stringLindsey S Garver
Junlin Wu
Louisa P Wu
P2860cites workInteractions between the cellular and humoral immune responses in DrosophilaQ47071148
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition proteinQ47071693
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Regulation of phagosome maturation by signals from toll-like receptorsQ47604798
Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient miceQ48254949
Drosophila scavenger receptor CI is a pattern recognition receptor for bacteriaQ48326967
An investigation into the compartmentalization of the sporulation transcription factor sigmaE in Bacillus subtilisQ57994011
A peptidoglycan recognition protein in innate immunity conserved from insects to humansQ24324731
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Innate immune responses in peptidoglycan recognition protein L-deficient miceQ24563057
Peptidoglycan types of bacterial cell walls and their taxonomic implicationsQ24563299
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activityQ24804561
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogasterQ27641639
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responsesQ28345340
A pattern recognition protein for peptidoglycan. Cloning the cDNA and the gene of the silkworm, Bombyx moriQ30671199
A scavenger function for a Drosophila peptidoglycan recognition protein.Q31122252
The Drosophila caspase Dredd is required to resist gram-negative bacterial infectionQ33757075
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvaeQ34160635
The Zuker collection: a resource for the analysis of autosomal gene function in Drosophila melanogasterQ34644739
The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.Q35076378
A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunityQ35204820
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogasterQ35575625
Peptidoglycan recognition proteins (PGRPs).Q35617624
Peptidoglycan recognition proteins: on and off switches for innate immunityQ35806851
Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunityQ37671859
Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils.Q38291429
Staphylococcus aureus RN6390 replicates and induces apoptosis in a pulmonary epithelial cell line.Q39538255
Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathwayQ40109933
Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycanQ40643709
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.Q40807096
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathwayQ42044755
Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growthQ42056505
Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx moriQ42064170
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosisQ43796120
A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascadeQ44194764
The Drosophila immune system detects bacteria through specific peptidoglycan recognitionQ44985652
Relish, a central factor in the control of humoral but not cellular immunity in DrosophilaQ45007881
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in DrosophilaQ47070084
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition proteinQ47070585
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coliQ47070787
Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteriaQ47070853
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphagocytosisQ184726
Staphylococcus aureusQ188121
DrosophilaQ312154
CG8577 gene product from transcript CG8577-RB Dmel_CG8577Q39546406
P304page(s)660-665
P577publication date2006-01-09
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila
P478volume103

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cites work (P2860)
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