Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

scientific article published on November 1, 2003

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI200317700
10.1172/JCI17700
P953full work available at URLhttps://europepmc.org/articles/PMC228400
https://europepmc.org/articles/PMC228400?pdf=render
https://doi.org/10.1172/jci200317700
P932PMC publication ID228400
P698PubMed publication ID14597765

P50authorJunichi SadoshimaQ51313947
Stephen F VatnerQ96766914
P2093author name stringJing Liu
Xianzhong Yu
Thomas Wagner
Chull Hong
Guiping Yang
Eric Holle
Mitsutaka Yamamoto
P2860cites workCancer ResearchQ326097
Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation.Q44468962
Redox regulation of cell signallingQ44950052
Thioredoxin overexpression in transgenic miceQ48659077
Thioredoxin and thioredoxin reductaseQ71521704
Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophyQ71807337
Upregulation of thioredoxin (TRX) expression in giant cell myocarditis in ratsQ73713267
Serum thioredoxin (TRX) levels in patients with heart failureQ74024277
Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin IIQ77198542
Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytesQ77927017
Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitroQ78031799
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.Q24533236
Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid systemQ28139055
Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxinQ28208305
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesQ28241500
Direct association with thioredoxin allows redox regulation of glucocorticoid receptor functionQ28294971
Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxinQ28581284
Reversible inactivation of the tumor suppressor PTEN by H2O2Q29615204
Phage display identifies thioredoxin and superoxide dismutase as novel protein kinase C-interacting proteins: thioredoxin inhibits protein kinase C-mediated phosphorylation of histoneQ30785404
Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusionQ31034023
Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systemsQ31096762
Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytesQ31763854
Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouseQ33858191
Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2Q33861934
Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent mannerQ34135937
Redox regulation of cellular activationQ34425412
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous miceQ34463545
Thioredoxin. OverviewQ34566282
Role of oxidative stress in myocardial hypertrophy and failureQ34625613
Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failureQ34667660
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.Q34793636
Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damageQ36459878
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic miceQ40388321
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.Q40928766
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.Q42526186
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cellsQ42806146
Overexpression of metallothionein reduces diabetic cardiomyopathy.Q43833575
The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload modelQ43899371
Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicityQ44131325
Thioredoxin-dependent redox regulation of p53-mediated p21 activationQ44275159
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectoxidative stressQ898814
P304page(s)1395-1406
P577publication date2003-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleInhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
P478volume112