PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor

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PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...737103Z
P356DOI10.1371/JOURNAL.PONE.0037103
P932PMC publication ID3353882
P698PubMed publication ID22615911
P5875ResearchGate publication ID225030154

P50authorWenshuo ZhangQ57337293
P2093author name stringMatthew J Brady
Robert M Sargis
Christopher M Carmean
Paul A Volden
Xiao J Sun
P2860cites workThe 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compoundsQ24657959
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Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systemsQ40661411
The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compoundsQ40815544
Reduced activities of key enzymes of gluconeogenesis as possible cause of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in ratsQ41155273
Reduction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is due to decreased mRNA levelsQ42558622
Direct and indirect effects of insulin on glucose uptake and storage by the liverQ44007177
Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanismQ44085291
In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humansQ44945885
Altered in vivo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C-SRC deficient miceQ46225042
Fasting augments PCB impact on liver metabolism in anadromous arctic charQ46990529
Polychlorinated biphenyls affect the activities of gluconeogenic and lipogenic enzymes in rat liver: is there an interference with regulatory hormone actions?Q47984959
Cytotoxic effects of Aroclor 1254 on ultrastructure and biochemical parameters in cultured foetal rat hepatocytesQ49226469
???Q28321842
Role of fat-derived substrates in the regulation of gluconeogenesis during fasting.Q51581463
Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver.Q51632674
Hormonal control of glycogenolysis and gluconeogenesis in isolated rat liver cells.Q51677737
PCB and PBDE levels in wild common carp (Cyprinus carpio) from eastern Lake Erie.Q52601935
Pathologic alterations in adult rainbow trout, Oncorhynchus mykiss, exposed to dietary 2,3,7,8-tetrachlorodibenzo-p-dioxinQ61463189
Tissue-specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated ratsQ67976568
Decreased hepatic phosphoenolpyruvate carboxykinase gene expression after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment: implications for the acute toxicity of chlorinated dibenzo-p-dioxins in the ratQ68025665
Determination of glycogen with the anthrone reagentQ68564783
Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigsQ69630169
2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks the physiological regulation of hepatic phosphoenolpyruvate carboxykinase activity in primary rat hepatocytesQ70796744
Tissue-specific effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on the activity of phosphoenolpyruvate carboxykinase (PEPCK) in ratsQ70855291
Correlation between toxicity and effects on intermediary metabolism in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male C57BL/6J and DBA/2J miceQ72601032
Ethoxyresorufin-O-deethylase and porphyrin analysis in chicken embryo hepatocyte cultures with a fluorescence multiwell plate readerQ72810174
Mouse liver cell culture. I. Hepatocyte isolationQ72915075
Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in miceQ74522140
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strainsQ78126563
Converting Toxic Equivalents (TEQ) of dioxins and dioxin-like compounds in fish from one Toxic Equivalency Factor (TEF) scheme to anotherQ80877968
CYP1A1-inducing potency in H4IIE cells and chemical composition of technical mixtures of polychlorinated biphenylsQ84586054
The biological pathway and effect of PCBs on common terns in Lake MichiganQ84776040
Delayed wasting syndrome and alterations of liver gluconeogenic enzymes in rats exposed to the TCDD congener 3,3', 4,4'-tetrachloroazoxybenzeneQ93585654
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e37103
P577publication date2012-05-16
P1433published inPLOS OneQ564954
P1476titlePCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor
P478volume7

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