Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.

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Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease. is …
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P6179Dimensions Publication ID1018487339
P356DOI10.1186/1742-4690-7-89
P932PMC publication ID2974656
P698PubMed publication ID20950436
P5875ResearchGate publication ID47447752

P50authorHans-Georg KräusslichQ1576991
Dirk JochmansQ56450393
Barbara MüllerQ67532985
P2093author name stringMaria Anders
Liesbeth Smeulders
Günter Kraus
Inge Keuleers
P2860cites workProcessing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different ratesQ24812175
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
Non-viral cellular substrates for human immunodeficiency virus type 1 proteaseQ28264830
Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-PolQ28469069
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremiaQ28469175
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
Isolation of mutants of human immunodeficiency virus protease based on the toxicity of the enzyme in Escherichia coliQ33703756
Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic proteinQ33750683
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.Q33785282
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translationQ33948995
Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapyQ33962223
Enzymatic detection of protein translocationQ34428441
Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989-2009).Q35005228
Apoptosis as an HIV strategy to escape immune attackQ35136008
The kappaB sites in the human immunodeficiency virus type 1 long terminal repeat enhance virus replication yet are not absolutely required for viral growthQ35888601
Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivoQ35914355
Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptaseQ36297904
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapyQ36499290
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency.Q36636632
Beta galactosidase complementation: a cell-based luminescent assay platform for drug discoveryQ36758566
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionQ36781531
Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion productionQ36797953
HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-Infected CellsQ36901499
Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitorQ37072072
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapyQ37200979
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panelQ37234205
Gene expression and cell fusion analyzed by lacZ complementation in mammalian cellsQ37239978
Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2Q37356313
The challenge of finding a cure for HIV infectionQ37407598
Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivityQ37480211
IDX-899, an aryl phosphinate-indole non-nucleoside reverse transcriptase inhibitor for the potential treatment of HIV infectionQ37683631
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.Q39579012
Alpha complementation of LacZ in mammalian cellsQ39715815
MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cellsQ39959363
Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivativeQ39991984
The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions.Q40042979
Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formationQ40049266
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitorsQ40206176
Double-labelled HIV-1 particles for study of virus-cell interaction.Q40209637
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitorQ40367975
Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particlesQ41564861
HIV protease cleaves poly(A)-binding protein.Q42533713
Efavirenz binding to HIV-1 reverse transcriptase monomers and dimersQ42738742
Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infectionQ43418787
Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppressionQ43655245
Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapyQ43807839
Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stabilityQ45001878
Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formationQ45218379
A sensitive method for the detection of beta-galactosidase in transfected mammalian cellsQ45349737
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.Q45860281
A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibilityQ46295068
Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse transcriptaseQ46964863
Mutation of the major 5' splice site renders a CMV-driven HIV-1 proviral clone Tat-dependent: connections between transcription and splicing.Q47822116
Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panelQ50105738
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infectionQ58198364
RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric formsQ59663057
Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapyQ73162446
Cell killing by HIV-1 proteaseQ78346287
Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in manQ94702271
P304page(s)89
P577publication date2010-10-15
P1433published inRetrovirologyQ15793508
P1476titleSelective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
P478volume7