Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL

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Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.131.4.951
P932PMC publication ID2200010
P698PubMed publication ID7490296
P5875ResearchGate publication ID15709397

P50authorWayne I. LencerQ38328140
Michael G JoblingQ58322288
P2093author name stringH M Webb
R K Holmes
J L Madara
T R Hirst
S Moe
C Constable
S Ruston
P2860cites workBrefeldin A: insights into the control of membrane traffic and organelle structureQ24643698
Lactose binding to heat-labile enterotoxin revealed by X-ray crystallographyQ27644363
The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval systemQ27935817
A C-terminal signal prevents secretion of luminal ER proteinsQ29618994
Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulumQ29620019
Carboxy-terminal SEKDEL sequences retard but do not retain two secretory proteins in the endoplasmic reticulum.Q30374249
Transcytosis of cholera toxin subunits across model human intestinal epithelia.Q33817778
Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generationQ33910366
Lipid sorting in epithelial cellsQ34048821
Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulumQ34233252
Enhancement of choleragen ADP-ribosyltransferase activities by guanyl nucleotides and a 19-kDa membrane proteinQ34332497
Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory siteQ35043377
Interaction of cholera toxin and membrane GM1 ganglioside of small intestineQ35083242
Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxinQ35655408
Occluding junction structure-function relationships in a cultured epithelial monolayerQ36213963
Endocytosis in filter-grown Madin-Darby canine kidney cells.Q36222228
Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.Q36222258
Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptorQ36232312
Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cellsQ36234982
The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack.Q36382534
Retrieval of transmembrane proteins to the endoplasmic reticulumQ36383169
Plasma membrane protein sorting in polarized epithelial cellsQ36530949
Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cellsQ36531164
Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular trafficQ36531474
Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimerasQ36971660
Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicityQ37664951
The retention signal for soluble proteins of the endoplasmic reticulumQ37782989
Activation of Adenylate Cyclase by CholeragenQ38000341
Metabolism and intracellular transport of glycosphingolipidsQ38020253
Mechanism of action of cholera toxin: Effect of receptor density and multivalent binding on activation of adenylate cyclaseQ38357236
Lipid traffic in animal cellsQ38737571
Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptorQ39807792
Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit compositionQ40231666
Construction of vectors with the p15a replicon, kanamycin resistance, inducible lacZ alpha and pUC18 or pUC19 multiple cloning sitesQ40523796
Positive and negative regulation of chloride secretion in T84 cellsQ40779327
Sorting of membrane proteins in the secretory pathwayQ40781366
Transport and sorting of membrane lipidsQ40788820
Cholesterol and the Golgi apparatusQ40840990
Ganglioside metabolism. Enzymology, Topology, and regulationQ40884774
Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartmentQ41091716
Endocytosis of cholera toxin in GERL-like structures of murine neuroblastoma cells pretreated with GM1 ganglioside. Cholera toxin internalization into Neuroblastoma GERLQ41253080
Transcytosis of the G protein of vesicular stomatitis virus after implantation into the apical plasma membrane of Madin-Darby canine kidney cells. I. Involvement of endosomes and lysosomesQ41465036
Orientation of cholera toxin bound to target cells.Q41533992
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.Q41548108
Endocytic pathways in polarized Caco-2 cells: identification of an endosomal compartment accessible from both apical and basolateral surfacesQ41745312
Established intestinal cell lines as model systems for electrolyte transport studiesQ41755985
Recycling of proteins from the Golgi compartment to the ER in yeastQ41909120
A homologue of the Escherichia coli DsbA protein involved in disulphide bond formation is required for enterotoxin biogenesis in Vibrio choleraeQ42599846
Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharideQ42844055
Lipid phase separations induced by the association of cholera toxin to phospholipid membranes containing ganglioside GM1.Q44742386
Uptake and metabolism of exogenous gangliosides by cultured cells: effect of choleragen on the turnover of GM1.Q45047566
Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulumQ46051539
Deactivation of Cholera Toxin by a Sialidase-Resistant MonosialosylgangliosideQ46540211
Gangliosides and membrane receptors for cholera toxinQ47972854
Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin.Q54613589
Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli.Q54696665
Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.Q55489693
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxinsQ59078570
Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulumQ59097697
Different sorting of Lys-Asp-Glu-Leu proteins in rat liverQ67848551
Production and purification of cholera toxinQ68041266
Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1Q68389213
Convergence of apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivoQ68659762
ADP ribosylation of membrane proteins from human fibroblasts. Effect of prior exposure of cells to choleragenQ70764563
Toxin entry: how reversible is the secretory pathway?Q75292684
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcholeraQ12090
Escherichia coliQ25419
P304page(s)951-962
P577publication date1995-11-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleTargeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL
P478volume131