Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro

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Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro is …
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scholarly articleQ13442814

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P356DOI10.3892/ETM.2014.1950
P932PMC publication ID4186337
P698PubMed publication ID25289054
P5875ResearchGate publication ID266625520

P2093author name stringChao Fu
Zhi Cong Wang
Hui Jun Sun
Kai Hua Li
Mo Zhen Liu
P2860cites workIcariin promotes extracellular matrix synthesis and gene expression of chondrocytes in vitroQ83394401
The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs.Q33686537
Osteoarthritic chondrocyte–secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cellsQ34011398
Adult bone marrow stem cells in cartilage therapy.Q34208724
Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha.Q34470598
Effect of parathyroid hormone-related protein in an in vitro hypertrophy model for mesenchymal stem cell chondrogenesis.Q36781439
Epidemiology and burden of osteoarthritisQ36949076
Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries.Q37456193
Induction of mesenchymal stem cell chondrogenesis by polyacrylate substratesQ39226706
Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell lineQ39306623
Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitroQ39981527
Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification.Q40244153
Micromass co-culture of human articular chondrocytes and human bone marrow mesenchymal stem cells to investigate stable neocartilage tissue formation in vitro.Q42868770
Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradationQ43179900
Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expressionQ43277758
An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis.Q46012525
Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1.Q46079673
The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells.Q46292156
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationQ46297071
Effect of Chinese traditional herb Epimedium grandiflorum C. Morren and its extract Icariin on osteoarthritis via suppressing NF-kappaB pathwayQ47703328
The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient miceQ47819485
Chondrogenic differentiation of amniotic fluid-derived stem cells.Q50946606
Local BMP-7 release from a PLGA scaffolding-matrix for the repair of osteochondral defects in rabbits.Q53364398
Icariin: a potential promoting compound for cartilage tissue engineering.Q54295423
Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.Q54791110
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID miceQ59348563
P433issue5
P921main subjectmesenchymal stem cellQ1922379
bone marrowQ546523
P304page(s)1528-1534
P577publication date2014-09-08
P1433published inExperimental and Therapeutic MedicineQ23979083
P1476titleIcariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro
P478volume8

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cites work (P2860)
Q36814432Bioimaging: An Useful Tool to Monitor Differentiation of Human Embryonic Stem Cells into Chondrocytes
Q54095350Cartilage Tissue Engineering Via Icariin and Adipose-derived Stem Cells in Fibrin Scaffold.
Q28553048Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair
Q36274103Histological observation of a gelatin sponge transplant loaded with bone marrow-derived mesenchymal stem cells combined with platelet-rich plasma in repairing an annulus defect
Q54964086Icariin Ameliorate Thiram-Induced Tibial Dyschondroplasia via Regulation of WNT4 and VEGF Expression in Broiler Chickens.
Q57493183Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway
Q58701772Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein
Q52564424Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in self‑assembling peptide nanofiber hydrogel scaffolds.
Q64111379Integrated Multi-Assay Culture Model for Stem Cell Chondrogenic Differentiation
Q26765485Natural Products from Chinese Medicines with Potential Benefits to Bone Health