Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

scientific article published on May 29, 2012

Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...735981F
P5530Altmetric DOI10.1371/JOURNAL.PONE.0035981
P6409CORE output ID90295838
P6179Dimensions Publication ID1018232320
P356DOI10.1371/JOURNAL.PONE.0035981
P953full work available online athttp://eprints.whiterose.ac.uk/86668/
http://dx.plos.org/10.1371/journal.pone.0035981
https://europepmc.org/articles/PMC3362588
https://europepmc.org/articles/PMC3362588?pdf=render
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035981&type=printable
P932PMC publication ID3362588
P698PubMed publication ID22666318
P5875ResearchGate publication ID225187209
P1154Scopus EID2-s2.0-84861538114

P50authorPeter SelbyQ46220287
P2093author name stringPaul Evans
Peter J. Selby
Gordon Cook
Katherine McKinley
Sylvia Feyler
Christopher Parrish
Mike Short
Sarah Jarmin
Gina B. Scott
P2860cites workIL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1.Q82791344
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patientsQ42742001
Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.Q42747710
Human myeloma cell lines as a tool for studying the biology of multiple myeloma: a reappraisal 18 years afterQ42803845
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Establishment of five human myeloma cell linesQ42816610
Two functional subsets of FOXP3+ regulatory T cells in human thymus and peripheryQ43095588
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cellsQ45878833
IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cellsQ46040716
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cellsQ46490320
In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myelomaQ51985543
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.Q54641474
CD4+CD25+FoxP3+regulatory T cells are increased whilst CD3+CD4−CD8−αβTCR+Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burdenQ56461588
ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagementQ56905227
Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late RelapseQ58211903
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitisQ75303091
Molecular mechanisms and therapeutic reversal of immune suppression in cancerQ79787000
Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppressionQ80752312
CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancersQ81317188
Exposure to myeloma cell lysates affects the immune competence of dendritic cells and favors the induction of Tr1-like regulatory T cellsQ81510484
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cellsQ33873201
CD4+CD25+Foxp3+IFN-γ+ human induced T regulatory cells are induced by interferon-γ and suppress alloresponses nonspecificallyQ33929883
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitisQ34048386
TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cellsQ34565392
Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signalingQ34582454
Regulatory T cells in the induction and maintenance of peripheral transplantation toleranceQ35069619
The molecular mechanisms of Foxp3 gene regulation.Q35490792
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.Q35606345
Mechanism and therapeutic reversal of immune suppression in cancerQ35990479
Human CD4+ regulatory T cells and activation-induced tolerance.Q36127323
Immunotherapy in multiple myeloma--possibility or probability?Q36206601
Immune suppression by tumor-specific CD4+ regulatory T-cells in cancerQ36248401
Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic interventionQ36254020
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsivenessQ36370807
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
CD4 regulatory T cells in human cancer pathogenesisQ36526954
Improving antitumor immune responses by circumventing immunoregulatory cells and mechanismsQ36568027
Cancer immunosuppression and autoimmune disease: beyond immunosuppressive networks for tumour immunityQ36605447
The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer.Q37068196
Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cellsQ37085357
IL-17-producing human peripheral regulatory T cells retain suppressive functionQ37176541
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.Q37208910
Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.Q37234611
Regulatory T cells and the induction of IL-17.Q37349778
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor functionQ37405703
FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survivalQ40090775
CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patientsQ40212457
Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15.Q40797196
Transforming growth factor beta from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytesQ40909490
Production of fibronectin and adherence to fibronectin by human myeloma cell linesQ41465157
The yin and yang of signaling in Tregs and TH17 cellsQ41495335
Normal and neoplastic human plasma cells express bcl-2 antigen.Q41666022
Adaptive human regulatory T cells: myth or reality?Q41762576
Dysfunctional T regulatory cells in multiple myelomaQ41877240
Runx proteins regulate Foxp3 expressionQ42594337
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmultiple myelomaQ467635
P304page(s)e35981
P577publication date2012-05-29
P1433published inPLOS OneQ564954
P1476titleTumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent
Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent
P478volume7

Reverse relations

cites work (P2860)
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Q38053765Epigenetics, autoimmunity and hematologic malignancies: A comprehensive review
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Q84944212Has the T cell bitten off more than it can chew?
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Q92712433Mass Cytometry Discovers Two Discrete Subsets of CD39-Treg Which Discriminate MGUS From Multiple Myeloma
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