Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts

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Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...737467C
P356DOI10.1371/JOURNAL.PONE.0037467
P932PMC publication ID3359730
P698PubMed publication ID22666358
P5875ResearchGate publication ID225187248

P50authorStefano GoldwurmQ46714545
Graziella CappellettiQ48863525
Daniele CartelliQ55727681
Francesca CasagrandeQ59705976
Gianni PezzoliQ64796821
P2860cites workParkinson's disease: from monogenic forms to genetic susceptibility factorsQ22242870
Missing pieces in the Parkinson's disease puzzleQ22251063
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
LRRK2 controls synaptic vesicle storage and mobilization within the recycling poolQ24292798
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressQ24294466
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityQ24296955
A Family of Protein-Deglutamylating Enzymes Associated with NeurodegenerationQ24306808
The familial Parkinsonism gene LRRK2 regulates neurite process morphologyQ24317613
Primary skin fibroblasts as a model of Parkinson's diseaseQ26999310
Mutant Parkin impairs mitochondrial function and morphology in human fibroblastsQ28475596
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged miceQ28507051
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradationQ28572388
Post-translational modifications regulate microtubule functionQ29036830
Methods in mammalian autophagy researchQ29547276
Dynamic instability of microtubule growthQ29547522
Direct generation of functional dopaminergic neurons from mouse and human fibroblastsQ29616184
Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotionQ30502586
What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. 1992.Q33183248
What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic studyQ33220006
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respirationQ33346359
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylationQ33525587
Acetylated microtubules are required for fusion of autophagosomes with lysosomesQ33751982
Demonstration of a role for alpha-synuclein as a functional microtubule-associated proteinQ34345614
Free tubulin modulates mitochondrial membrane potential in cancer cellsQ34440476
Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease modelQ34637864
Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell deathQ35992163
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubulesQ36982616
Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activationQ37081948
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final stepsQ37376117
Hsp70 molecular chaperones and Parkinson's diseaseQ37600793
Axonal transport defects in neurodegenerative diseasesQ37614744
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeletonQ37764505
GSK3 signalling in neural developmentQ37774552
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patientsQ39699315
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?Q39834913
Parkin stabilizes microtubules through strong binding mediated by three independent domains.Q40452676
Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation.Q40622053
Protein tyrosine nitration is triggered by nerve growth factor during neuronal differentiation of PC12 cellsQ42445016
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.Q42790455
Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies.Q42798296
Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegenerationQ42962530
Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donorsQ43628484
Intrastriatal injection of colchicine induces striatonigral degeneration in miceQ46531671
Selective vulnerability of dopaminergic neurons to microtubule depolymerizationQ46642857
The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factorQ46649179
Rotenone inhibition of tubulin self-assemblyQ52428595
Stabilization of actin filaments at early times after adenovirus infection and in heat-shocked cellsQ52479902
Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease.Q54376355
Parkin analysis in early onset Parkinson's diseaseQ59768136
Chaperone-mediated inhibition of tubulin self-assemblyQ79624974
LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sampleQ83916757
Stiffening of Human Skin Fibroblasts with AgeQ85220870
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
Parkinson's diseaseQ11085
P304page(s)e37467
P577publication date2012-05-22
P1433published inPLOS OneQ564954
P1476titleMicrotubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts
P478volume7