Does M. tuberculosis genomic diversity explain disease diversity?

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Does M. tuberculosis genomic diversity explain disease diversity? is …
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scholarly articleQ13442814

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P356DOI10.1016/J.DDMEC.2010.09.004
P932PMC publication ID2976975
P698PubMed publication ID21076640
P5875ResearchGate publication ID47792037

P50authorSébastien GagneuxQ47007290
Mireia CoscollaQ56523288
P2093author name stringMireilla Coscolla
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BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system diseaseQ41379320
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Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigsQ44306950
Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.Q44553442
Strain-related virulence of the dominant Mycobacterium tuberculosis strain in the Canadian province of ManitobaQ44557232
Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypesQ44738814
The fate of virulent and attenuated Mycobacteria in guinea pigs infected by the respiratory routeQ44867327
Guinea-pig alveolar macrophages kill Mycobacterium tuberculosis in vitro, but killing is independent of susceptibility to hydrogen peroxide or triggering of the respiratory burstQ46231108
VIRULENCE IN THE GUINEA-PIG AND SUSCEPTIBLITY TO HYDROGEN PEROXIDE OF ISONIAZID-SENSITIVE TUBERCLE BACILLI FROM SOUTH INDIAN PATIENTS.Q46299477
Diversity of in vitro cytokine responses by human macrophages to infection by mycobacterium tuberculosis strainsQ46361152
Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitisQ46461006
VIRULENCE IN THE GUINEA-PIG, SUSCEPTIBILITY TO HYDROGEN PEROXIDE, AND CATALASE ACTIVITY OF ISONIAZID-SENSITIVE TUBERCLE BACILLI FROM SOUTH INDIAN AND BRITISH PATIENTS.Q46799337
Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathwayQ46828227
Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophagesQ47328803
Association between the infectivity of Mycobacterium tuberculosis strains and their efficiency for extrarespiratory infectionQ47690978
Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilliQ48864122
A mechanism of virulence: virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis.Q52569105
Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.Q53610312
Mycobacterium tuberculosis, Beijing genotype strains not associated with radiological presentation of pulmonary tuberculosis.Q53892460
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Molecular epidemiology of tuberculosisQ57095977
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Transmission of Tuberculosis in New York City -- An Analysis by DNA Fingerprinting and Conventional Epidemiologic MethodsQ58265072
Infection withMycobacterium tuberculosisBeijing Genotype Strains Is Associated with Polymorphisms inSLC11A1/NRAMP1in Indonesian Patients with TuberculosisQ58379339
Mycobacterium tuberculosis lipids regulate cytokines, TLR-2/4 and MHC class II expression in human macrophagesQ58608724
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune responseQ59057817
In Vivo Phenotypic Dominance in Mouse Mixed Infections withMycobacterium tuberculosisClinical IsolatesQ60914355
Protein expression by a Beijing strain differs from that of another clinical isolate and Mycobacterium tuberculosis H37RvQ62084119
Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy childrenQ63916849
An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosisQ64133339
Virulence of tubercle bacilli isolated from patients with tuberculosis in Bangalore, IndiaQ70361424
Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophagesQ71755919
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Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alphaQ77186410
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Clinical relevance of Mycobacterium tuberculosis plcD gene mutationsQ37282843
Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica.Q37333410
Drivers of tuberculosis epidemics: the role of risk factors and social determinantsQ37459996
Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesisQ37521603
Group B streptococci escape host immunity by deletion of tandem repeat elements of the alpha C proteinQ37630658
Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis.Q37634147
Recent and rapid emergence of W-Beijing strains of Mycobacterium tuberculosis in Cape Town, South AfricaQ38424744
An assay to compare the infectivity of Mycobacterium tuberculosis isolates based on aerosol infection of guinea pigs and assessment of bacteriologyQ38447337
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ALOX5 variants associated with susceptibility to human pulmonary tuberculosisQ39064559
Virulence and Resistance to Superoxide, Low pH and Hydrogen Peroxide among Strains of Mycobacterium tuberculosisQ39182715
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The Correlation of Bacteriophage Types of Mycobacterium tuberculosis with Guinea-pig Virulence and In vitro-indicators of VirulenceQ39506456
Growth rate of mycobacteria in mice as an unreliable indicator of mycobacterial virulence.Q39512426
Transmission of tuberculosis in a jailQ39519951
Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitroQ39655566
Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for miceQ39821342
Mycobacterial growth and sensitivity to H2O2 killing in human monocytes in vitroQ39831579
Reduced TNF-alpha and IFN-gamma responses to Central Asian strain 1 and Beijing isolates of Mycobacterium tuberculosis in comparison with H37Rv strainQ39859674
Induction of cell death in human macrophages by a highly virulent Korean Isolate of Mycobacterium tuberculosis and the virulent strain H37RvQ39895901
Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics.Q40021876
The competitive cost of antibiotic resistance in Mycobacterium tuberculosisQ40311130
Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP seQ34303290
Stable association between strains of Mycobacterium tuberculosis and their human host populationsQ34308443
Mycobacterium tuberculosis Beijing genotype and risk for treatment failure and relapse, VietnamQ34555065
Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international studyQ34991344
Comparing genomes within the species Mycobacterium tuberculosisQ35033207
Molecular epidemiology of tuberculosis: current insightsQ35070843
A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversionQ35108344
Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitisQ35220932
Population-based study of deletions in five different genomic regions of Mycobacterium tuberculosis and possible clinical relevance of the deletionsQ35220950
Virulence ranking of some Mycobacterium tuberculosis and Mycobacterium bovis strains according to their ability to multiply in the lungs, induce lung pathology, and cause mortality in miceQ35435985
Association between Mycobacterium tuberculosis Beijing/W lineage strain infection and extrathoracic tuberculosis: Insights from epidemiologic and clinical characterization of the three principal genetic groups of M. tuberculosis clinical isolatesQ35690557
The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulatedQ35759546
A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause diseaseQ35784560
Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosisQ35872892
Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /betaQ35894501
Beijing/W genotype Mycobacterium tuberculosis and drug resistanceQ36029451
Different Strains ofMycobacterium tuberculosisCause Various Spectrums of Disease in the Rabbit Model of TuberculosisQ36046773
Effects of genetic variability of Mycobacterium tuberculosis strains on the presentation of diseaseQ36070678
Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.Q36098732
Genetic susceptibility to mycobacterial disease in humansQ36414900
Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosisQ36539881
The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guérin (BCG) vaccines: is there a link?Q36565187
Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancyQ36710576
The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulenceQ36747037
Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.Q36797710
Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig modelQ36948262
Growth characteristics of recent sputum isolates of Mycobacterium tuberculosis in guinea pigs infected by the respiratory routeQ36970963
Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The GambiaQ37001570
Mycobacterium tuberculosis Beijing genotype emerging in VietnamQ37093922
Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains.Q37133287
Major Mycobacterium tuberculosis lineages associate with patient country of originQ37156812
Use of spoligotyping and large sequence polymorphisms to study the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive smear-positive tuberculosis cases in The GambiaQ37156954
The clinical consequences of strain diversity in Mycobacterium tuberculosisQ37177756
Systems biology of persistent infection: tuberculosis as a case studyQ37184399
P433issue1
P921main subjectMycobacterium tuberculosisQ130971
tuberculosisQ12204
biodiversityQ47041
P304page(s)e43-e59
P577publication date2010-01-01
P1433published inDrug discovery today. Disease mechanismsQ27721894
P1476titleDoes M. tuberculosis genomic diversity explain disease diversity?
P478volume7

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