Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation

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Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation is …
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scholarly articleQ13442814

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P356DOI10.1016/S0014-5793(04)00274-1
P698PubMed publication ID15063729

P50authorAkio KiharaQ42656232
P2093author name stringYasuyuki Igarashi
Yukiko Mizutani
P2860cites workBiosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backboneQ70613520
Phytosphingosine groups as quantitatively significant components of the sphingolipids of the mucosa of the small intestines of some mammalian speciesQ72132625
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EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissueQ22004152
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesisQ24310707
Functional rafts in cell membranesQ27860768
Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domainQ27929876
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7pQ27931048
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiaeQ27936644
Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptorQ28203357
Identification and characterization of a sphingolipid delta 4-desaturase familyQ28506937
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramideQ28634069
Ceramides and skin function.Q34173318
Enzymes of sphingolipid metabolism: from modular to integrative signalingQ34220989
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function.Q36524482
Desaturation and hydroxylation. Residues 148 and 324 of Arabidopsis FAD2, in addition to substrate chain length, exert a major influence in partitioning of catalytic specificityQ38291662
Sphingolipid metabolism and cell growth regulation.Q41198130
Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte culturesQ43800870
Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitisQ44091743
Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endodermQ44313347
Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cellsQ44522028
Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.Q44565276
Ceramide and cholesterol composition of the skin of patients with atopic dermatitis.Q50903373
Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipidsQ56902436
Ceramide composition of the psoriatic scaleQ59242383
P433issue1-3
P407language of work or nameEnglishQ1860
P921main subjectsphingolipidsQ410395
keratinocyteQ1473931
P304page(s)93-97
P577publication date2004-04-01
P1433published inFEBS LettersQ1388051
P1476titleIdentification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
P478volume563