Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

scientific article

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20031579
P932PMC publication ID2211881
P698PubMed publication ID15067033
P5875ResearchGate publication ID8634622

P50authorHoward L. WeinerQ20985921
David A. HaflerQ25004567
P2093author name stringClare Baecher-Allan
Vissia Viglietta
P2860cites workCytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 ProductionQ29619536
Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme diseaseQ30665597
Regulatory T cells in autoimmmunity*.Q33904108
Regulatory T cells: key controllers of immunologic self-toleranceQ33941140
Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitroQ33942128
The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesisQ34238431
Control of T‐cell activation by CD4+ CD25+ suppressor T cellsQ34448423
Inhibition of human CD4(+)CD25(+high) regulatory T cell functionQ34529239
Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.Q34674896
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune diseaseQ34693075
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetesQ34790295
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cellsQ37378116
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.Q40801370
Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human bloodQ41973912
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjectsQ44887481
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cellsQ54139898
CD4+CD25high regulatory cells in human peripheral bloodQ56905059
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulationQ56907887
T cell tolerance by clonal elimination in the thymusQ56922465
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosisQ59049915
CD4+ T-cells in the regulation of inflammatory responses in the intestineQ74552673
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7Q74650540
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitisQ78404404
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cellsQ79253316
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmultiple sclerosisQ8277
patientQ181600
P304page(s)971-979
P577publication date2004-04-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleLoss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
P478volume199