Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation

scientific article

Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1989PNAS...86.8024R
P356DOI10.1073/PNAS.86.20.8024
P932PMC publication ID298206
P698PubMed publication ID2813375
P5875ResearchGate publication ID20343620

P2093author name stringT Kishimoto
T Hirano
L Mayer
M C Raynal
S Chen-Kiang
Z Y Liu
P2860cites workComplementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulinQ24299103
The nucleotide sequence of a human immnnoglobulin CγlgeneQ24301166
Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequencesQ24594225
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining regionQ28115405
Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genesQ28259844
Structure of human immunoglobulin gamma genes: implications for evolution of a gene familyQ28274240
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' endsQ34056363
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathwaysQ34268965
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin geneQ34369553
Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte developmentQ35046574
Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primerQ35314314
Immunoglobulin mRNA stability varies during B lymphocyte differentiationQ35980376
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic familyQ36136925
Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytesQ36342209
Transcriptional regulation of the mu-delta heavy chain locus in normal murine B lymphocytesQ36349352
The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 spliceQ36766537
Cell-specific expression of secreted versus membrane forms of immunoglobulin gamma 2b mRNA involves selective use of alternate polyadenylation sitesQ36893997
Cell-type-specific synthesis of murine immunoglobulin mu RNA from an adenovirus vectorQ36908553
Sequences near the 3' secretion-specific polyadenylation site influence levels of secretion-specific and membrane-specific IgG2b mRNA in myeloma cellsQ36914137
Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intronQ37408665
Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA.Q37558395
Pausing and premature termination of human RNA polymerase II during transcription of adenovirus in vivo and in vitroQ37569616
Molecular regulation of B lymphocyte responseQ39647353
Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytesQ39703749
The nature of the stimulatory cell in human allogeneic and autologous MLC reactions; role of isolated IgM-bearing B cellsQ39893876
Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin geneQ41841618
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cellsQ41867235
Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell developmentQ41903016
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chainQ43447845
A plaque assay for all cells secreting Ig of a given type or classQ44062553
Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator elementQ44346389
Induction of kappa transcription by interferon-gamma without activation of NF-kappa B.Q46105265
Clustered arrangement of immunoglobulin λ constant region genes in manQ48407182
Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants.Q52251563
Mode of regulation of immunoglobulin mu- and delta-chain expression varies during B-lymphocyte maturation.Q52276349
T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.Q52828600
Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unitQ64381289
The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomesQ64449065
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase IIQ69827439
Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell linesQ69936852
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)8024-8028
P577publication date1989-10-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInterleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation
P478volume86

Reverse relations

cites work (P2860)
Q35872068A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region
Q41081406A pause site for RNA polymerase II is associated with termination of transcription
Q30442717CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
Q36679250Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells
Q73385965Eμ/Sμ transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells
Q36643268Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region
Q34009997IL-6 transgenic mouse model for extraosseous plasmacytoma
Q73115260Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
Q37557161Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation
Q36352092Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms
Q41562455Interleukin 6 is not required for antigen-specific antibody responses by human B cells
Q41121963Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line
Q35320801Lymphokine production by B cells from normal and HIV-infected individuals
Q24609459NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1
Q36690638NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A
Q43808671Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation
Q41655905Soluble IL-6R in plasma cell dyscrasias
Q36815211Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene
Q42159409The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility b
Q33706908Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.
Q43973953Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease