Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma

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Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-11-0578
P932PMC publication ID4193939
P698PubMed publication ID21933888

P50authorC P ReynoldsQ67015887
P2093author name stringHua Fang
Yves A DeClerck
Ondrej Kalous
Vanessa Maldonado
Theresa M Harned
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An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsQ29620467
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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.Q35250940
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Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.Q39993903
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatinQ40041107
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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.Q40126446
Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-X-SORB organized lipid complexQ40132570
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.Q40174205
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell linesQ40785878
Cancer statistics, 1999.Q40817780
Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell lineQ41098628
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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocationQ44926251
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Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistanceQ46093621
Determination of subcutaneous tumor size in athymic (nude) miceQ46296687
Retinoic-acid-resistant neuroblastoma cell lines show altered MYC regulation and high sensitivity to fenretinide.Q46947417
Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive InhibitorsQ52739596
Characterization of human neuroblastoma cell lines established before and after therapy.Q52834184
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.Q53595735
Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: apoptosis versus differentiationQ72532669
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Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllinQ73154723
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)7093-7104
P577publication date2011-09-20
P1433published inClinical Cancer ResearchQ332253
P1476titleSynergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma
P478volume17

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cites work (P2860)
Q90590054A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma
Q35781382A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide
Q38982534Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines.
Q28485302Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma
Q91651290Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment
Q37375377Combination of fenretinide and selenite inhibits proliferation and induces apoptosis in ovarian cancer cells
Q38944587Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells
Q40185074Mild thermotolerance induced at 40 °C protects cells against hyperthermia-induced pro-apoptotic changes in Bcl-2 family proteins.
Q39347735Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma
Q38710659P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Q39268126RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance
Q39106943Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel
Q39944723The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway
Q28487756The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity
Q38876333Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.
Q42117299Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine
Q49907165p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells

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