Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred

scientific article

Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJM200108023450502
P698PubMed publication ID11484688

P2093author name stringNewman JH
Wheeler L
Loyd JE
Phillips JA 3rd
Lane KB
Gaddipati R
Loyd E
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectprimary pulmonary hypertensionQ18554794
morphogenesisQ815547
P1104number of pages6
P304page(s)319-324
P577publication date2001-08-01
P1433published inThe New England Journal of MedicineQ582728
P1476titleMutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
P478volume345

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cites work (P2860)
Q88690808A Review of Transcriptome Analysis in Pulmonary Vascular Diseases
Q30544892A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
Q37359026A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension
Q33970081A novel BMPR2 mutation associated with pulmonary arterial hypertension in an octogenarian
Q51192735A novel break point of the BMPR2 gene exonic deletion in a patient with pulmonary arterial hypertension.
Q37104263A potential role for insulin resistance in experimental pulmonary hypertension
Q42340418A review of pulmonary arterial hypertension: Part 1. Novel insights and classification
Q35600688Activation of K+ channels: an essential pathway in programmed cell death
Q37755020Advances in therapies for pediatric pulmonary arterial hypertension
Q80094203Association of HLA class II genes with idiopathic pulmonary arterial hypertension in Koreans
Q47948580BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
Q38799538BMPR2 gene therapy for PAH acts via Smad and non-Smad signalling.
Q31038850BMPR2 revisited: are bigger data better?
Q36185917Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension
Q46515326Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells
Q73376498Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
Q24791993Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension
Q35005853Building the case for novel clinical trials in pulmonary arterial hypertension
Q26766294Challenges and Current Efforts in the Development of Biomarkers for Chronic Inflammatory and Remodeling Conditions of the Lungs
Q34199837Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice
Q55286562Clinical and genetic characteristics of pulmonary arterial hypertension in Lebanon.
Q44096475Clinical outcomes of pulmonary arterial hypertension in carriers of BMPR2 mutation.
Q39021300Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study.
Q33155179Clinical presentation, differential diagnosis, and vasodilator testing of pulmonary hypertension
Q35024562Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats
Q35412283Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension
Q38450447Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension
Q35673783Current clinical management of pulmonary arterial hypertension
Q36225802Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension
Q33786374Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease
Q44180844Dexfenfluramine protects against pulmonary hypertension in rats
Q39010196Diagnosis, Treatment, and Clinical Management of Pulmonary Arterial Hypertension in the Contemporary Era: A Review
Q44407006Disease-associated mutations in conserved residues of ALK-1 kinase domain
Q28572271Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension
Q37394425EIF2AK4 mutation as "second hit" in hereditary pulmonary arterial hypertension
Q36940790Eisenmenger syndrome and atrial septal defect: nature or nurture?
Q44487846Emerging therapies for pulmonary hypertension: striving for efficacy and safety
Q34631613Endothelin in health and disease: endothelin receptor antagonists in the management of pulmonary artery hypertension
Q37901411From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension
Q36934968Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation
Q33372590Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance
Q37827155Gene therapy for pulmonary hypertension: prospects and challenges
Q34801954Genetic counselling for pulmonary arterial hypertension: a matter of variable variability
Q24806161Genetic epidemiology: systemic sclerosis
Q37051037Genetics and genomics of pulmonary arterial hypertension
Q36752306Genetics and mediators in pulmonary arterial hypertension
Q34394986Genetics of primary pulmonary hypertension
Q34420043Genomics and proteomics of lung disease: conference summary
Q36016529HIV protease inhibitors in pulmonary hypertension: rationale and design of a pilot trial in idiopathic pulmonary arterial hypertension
Q91651407HYAL1 Is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits HFL-1 Fibroblast Proliferation When Upregulated
Q33761721Heart failure and pulmonary hypertension
Q42540943High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells
Q35217383Human immunodeficiency virus transgenic rats exhibit pulmonary hypertension
Q39150404Hypoxia downregulates PPARγ via an ERK1/2-NF-κB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells
Q58730399Identification of a low frequency missense mutation in MUC6 contributing to pulmonary artery hypertension by whole-exome sequencing
Q33788452Identifying "super responders" in pulmonary arterial hypertension.
Q28590362Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice
Q92189114Joint Transcriptomic Analysis of Lung Cancer and Other Lung Diseases
Q35136658Kinase activity profiling of gram-negative pneumonia
Q28361811Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension
Q93204496Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1
Q36488756Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension.
Q47449827Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition
Q39673639Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension
Q36477935Mediators and modulators of pulmonary arterial hypertension
Q38679814MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician.
Q37308092MicroRNAs in pulmonary arterial remodeling
Q34576173Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene
Q36943272Monocrotaline pyrrole induces Smad nuclear accumulation and altered signaling expression in human pulmonary arterial endothelial cells
Q36606635Mutations of TGFbeta signaling molecules in human disease
Q52997994Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.
Q34782501Myosin heavy chain 15 is associated with bovine pulmonary arterial pressure
Q64911746New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
Q34625826New treatments for pulmonary arterial hypertension
Q35750204Nitric oxide and other novel therapies for pulmonary hypertension
Q35165691Non-congenital heart disease associated pediatric pulmonary arterial hypertension
Q57091338Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders
Q26821779Pathobiology of pulmonary arterial hypertension and right ventricular failure
Q36447388Pathogenic mechanisms of pulmonary arterial hypertension
Q37144624Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
Q46686053Potent effects of aerosol compared with intravenous treprostinil on the pulmonary circulation
Q24633128Preparing for the first breath: genetic and cellular mechanisms in lung development
Q73370839Primary pulmonary hypertension
Q37084786Pulmonary arterial hypertension from a pediatric perspective
Q34950123Pulmonary arterial hypertension in congenital heart disease
Q36834617Pulmonary arterial hypertension: an overview
Q37671277Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response
Q38155079Pulmonary arterial hypertension: challenges in translational research and a vision for change
Q74117447Pulmonary hypertension: current criteria for diagnosis and treatment
Q35192891Pulmonary hypertension: work in progress
Q27687091Pulmonary vascular disease related to hemodynamic stress in the pulmonary circulation
Q41181690Pulmonary vascular diseases: in search of a hub among the spokes-an exercise in hypothesis generation
Q44225835Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II.
Q34383236Rat strain differences in pulmonary artery smooth muscle Ca(2+) entry following chronic hypoxia
Q38027723Regulatory T cells and pulmonary hypertension
Q38870144Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension.
Q44593177Retinal diseases with primary pulmonary hypertension
Q35905574Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension
Q55119395Reversible pulmonary artery perfusion abnormalities in the postpartum period as a precursor to the development of pulmonary arterial hypertension.
Q36596818Review of bosentan in the management of pulmonary arterial hypertension
Q37898745Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH.
Q33959437Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance.
Q28078566Role of oxidized lipids in pulmonary arterial hypertension
Q36605656Role of the endothelium in pulmonary arterial hypertension
Q33965854Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Genetics of pulmonary hypertension
Q34973575Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH.
Q35280612Severe paediatric pulmonary hypertension: new management strategies
Q44198491Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
Q35573926Surgical treatment of pulmonary hypertension: Lung transplantation
Q36340862TRAIL: not just for tumors anymore?
Q37346515The 'sweet' and 'bitter' involvement of glycosaminoglycans in lung diseases: pharmacotherapeutic relevance
Q28570134The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro
Q26744761The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension
Q45046014The Roles of Immunity in the Prevention and Evolution of Pulmonary Arterial Hypertension
Q36023813The biological "scrabble" of pulmonary arteriovenous malformations: considerations in the setting of cavopulmonary surgery
Q44693038The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux
Q35168404The endothelin system in pulmonary hypertension.
Q78348661The genetics of congenital heart disease: a point in the revolution
Q37782012The role of mitochondria in pulmonary vascular remodeling
Q35925357The role of peroxisome proliferator-activated receptors in pulmonary vascular disease
Q37090543Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension
Q50476552Translational Advances in the Field of Pulmonary Hypertension. Focusing on Developmental Origins and Disease Inception for the Prevention of Pulmonary Hypertension
Q49312062Translational Advances in the Field of Pulmonary Hypertension. Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than "miR" Words
Q42782703Treatment of pulmonary hypertension
Q34985847Treatment of pulmonary hypertension: a promising new age.
Q37389602Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
Q64939788United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications.
Q35916971Use of myocardial performance index in pediatric patients with idiopathic pulmonary arterial hypertension
Q55286414Using Omics to Understand and Treat Pulmonary Vascular Disease.
Q21245270Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals
Q35443190Visceral manifestations in hereditary haemorrhagic telangiectasia type 2
Q73511259[Consensus recommendations of the Pulmonary Arterial Hypertension Study Group of the Austrian Society of Lung Diseases and Tuberculosis]
Q80393837[Endothelial dysfunction in pulmonary hypertension]
Q79804168[Pulmonary arterial hypertension in collagenoses: clinical features, epidemiology, pathogenesis, diagnosis and treatment]
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