The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia.

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The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...739959B
P356DOI10.1371/JOURNAL.PONE.0039959
P932PMC publication ID3384594
P698PubMed publication ID22761937
P5875ResearchGate publication ID228116675

P50authorValentina BenfenatiQ53304456
P2093author name stringDavid Dzamba
Jana Benesova
Miroslava Anderova
Pavel Honsa
Vendula Rusnakova
Stefano Ferroni
Olena Butenko
P2860cites workHuman TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and traffickingQ24295521
Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding SiteQ24300879
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutationsQ24305183
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1Q28294822
Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytesQ28580537
Impact of global cerebral ischemia on K+ channel expression and membrane properties of glial cells in the rat hippocampusQ28581554
Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunitQ28591676
Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP miceQ28732871
Astrocytes, from brain glue to communication elements: the revolution continuesQ29619493
Identification and characterization of novel TRPV4 modulatorsQ33500893
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4Q33582066
Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenaseQ33612288
Cell death/proliferation and alterations in glial morphology contribute to changes in diffusivity in the rat hippocampus after hypoxia-ischemia.Q33704949
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivoQ33985913
Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes.Q50668443
High extracellular K(+) evokes changes in voltage-dependent K(+) and Na (+) currents and volume regulation in astrocytes.Q50712362
Cultured rat astrocytes possess Na(+)-Ca2+ exchangerQ72630595
Na+/Ca2+ exchanger modulates kainate-triggered Ca2+ signaling in Bergmann glial cells in situQ73486367
Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.Q42873472
Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosisQ43056605
Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture.Q43197572
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.Q43641903
Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activityQ43850153
Molecular determinants of permeation through the cation channel TRPV4.Q44047575
Functional NMDA Receptor Subtype 2B Is Expressed in Astrocytes after IschemiaIn Vivoand AnoxiaIn VitroQ44419002
Modulation of TRPV4 gating by intra- and extracellular Ca2+.Q44452825
Functional TRPV4 channels are expressed in human airway smooth muscle cellsQ44838169
Visualization of localized store-operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulumQ45282604
Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP miceQ46408158
Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytesQ46703786
Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices.Q46948484
Adult astroglia is competent for Na+/Ca2+ exchanger-operated exocytotic glutamate release triggered by mild depolarizationQ46951836
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes.Q46981387
Astrocytes from mouse brain slices express ClC-2-mediated Cl- currents regulated during development and after injury.Q48220531
Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca(i)2+-induced Ca2+ release in rat cerebellar Type-1 astrocytesQ48266102
Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4.Q48272542
Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells.Q48288174
Increased phase synchronization of spontaneous calcium oscillations in epileptic human versus normal rat astrocyte cultures.Q48294723
Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situQ48377983
Astroglia up-regulate transcription and secretion of 'readthrough' acetylcholinesterase following oxidative stressQ48449247
Heat-evoked activation of the ion channel, TRPV4.Q48526032
Potentiation of NMDA receptor currents by arachidonic acidQ48526957
Spontaneous intracellular calcium oscillations in cortical astrocytes from a patient with intractable childhood epilepsy (Rasmussen's encephalitis).Q48574254
Astrocytes in 17beta-estradiol treated mixed hippocampal cultures show attenuated calcium response to neuronal activityQ48604066
Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.Q49105101
Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K(+)](o) uptake capabilitiesQ49162446
Polydendrocytes display large lineage plasticity following focal cerebral ischemiaQ34271030
An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytesQ34572856
TRPV4.Q34600626
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmiaQ34790129
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.Q35123129
TRPV4 calcium entry channel: a paradigm for gating diversity.Q35621006
Defining pathways of loss and secretion of chemical messengers from astrocytesQ35836061
Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapyQ36104630
The mechanosensitive nature of TRPV channelsQ36134906
Physiology and pharmacology of two-pore domain potassium channelsQ36230168
TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions.Q36444424
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acidQ36527219
Vesicular transmitter release from astrocytesQ36606113
Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuliQ36684650
JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurementsQ36750848
What is the role of astrocyte calcium in neurophysiology?Q36758589
Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C.Q37116100
Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in ratsQ37120405
Astrocytes and ischemic injuryQ37122035
Pathological potential of astroglia.Q37164439
Physiological and pathological functions of P2X7 receptor in the spinal cordQ37389355
Differential calcium signalling in neuronal-glial networks.Q37410235
Hot flash: TRPV channels in the brain.Q37414701
Activation of the TRPV4 ion channel is enhanced by phosphorylation.Q37459860
Regulated exocytosis from astrocytes physiological and pathological related aspects.Q37553210
Heterogeneity in astrocyte morphology and physiologyQ37652218
Water transport between CNS compartments: functional and molecular interactions between aquaporins and ion channelsQ37660649
Glial calcium and diseases of the nervous systemQ37665998
TRP channels as mediators of oxidative stressQ37835147
TRPM7 in cerebral ischemia and potential target for drug development in strokeQ37873298
The progesterone receptor regulates the expression of TRPV4 channel.Q39809253
Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cellsQ39934880
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.Q40298502
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neuronesQ40356282
Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeetQ42528081
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
astrocyteQ502961
P304page(s)e39959
P577publication date2012-06-27
P1433published inPLOS OneQ564954
P1476titleThe increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia
P478volume7

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cites work (P2860)
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Q48455462Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice
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Q50102613Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?
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