The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis

scientific article

The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2252
P932PMC publication ID4196162
P698PubMed publication ID25149534
P5875ResearchGate publication ID286905455

P2093author name stringAnnalen Bleckmann
Walter Birchmeier
Maria Wiese
Christina Perske
Felix H Brembeck
Nathalie Zatula
Jens Bunzendahl
P2860cites workWnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complexQ24294443
Wnt/beta-catenin and estrogen signaling converge in vivoQ24300941
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotesQ24538709
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functionsQ24561624
JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 updateQ24650787
Wnt/β-catenin signaling and diseaseQ26823272
Sp1 is essential for estrogen receptor alpha gene transcriptionQ38361081
Epithelial-mesenchymal transition in breast cancer correlates with high histological grade and triple-negative phenotype.Q39375411
A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancersQ40021069
Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cellsQ40528114
Keratin 19 expression in the adult and developing human mammary glandQ41138370
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female miceQ41400379
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.Q41578212
The estrogen receptor gene: promoter organization and expressionQ41756430
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic gradeQ42510471
Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotypeQ44576030
Regulation of the estrogen receptor alpha minimal promoter by Sp1, USF-1 and ERalphaQ44866187
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.Q45749896
The lack of effect of phenol red or estradiol on the growth response of human, rat, and mouse mammary cells in primary cultureQ46137743
Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator functionQ47315034
Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoformQ48066328
BCL9-2 promotes early stages of intestinal tumor progression.Q52894492
Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.Q53336607
CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesionsQ77755081
The many faces and functions of β-cateninQ26865781
Minireview: genomic organization of the human ERalpha gene promoter regionQ28208469
Balancing cell adhesion and Wnt signaling, the key role of beta-cateninQ28288763
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomasQ28591317
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genomeQ29616165
A putative human breast stem cell population is enriched for steroid receptor-positive cellsQ33210333
The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cellsQ33351758
Genetic mechanisms in Apc-mediated mammary tumorigenesisQ33406237
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesisQ33478377
Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.Q33897191
Molecular and cellular determinants of estrogen receptor alpha expressionQ34181207
Key signaling nodes in mammary gland development and cancer: β-cateninQ34613461
Human estrogen receptor-alpha: regulation by synthesis, modification and degradation.Q34712217
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cellsQ34792452
Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cellsQ34814407
The changing role of pathology in breast cancer diagnosis and treatmentQ35082260
Novel patterns of genome rearrangement and their association with survival in breast cancerQ35173695
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesisQ35455993
Genetically engineered mouse models of mammary intraepithelial neoplasiaQ35671166
Mouse models of estrogen receptor-positive breast cancerQ35685892
Wnt proteins in mammary development and cancerQ35858238
Sp transcription factor family and its role in cancerQ36279169
Information networks in the mammary gland.Q36289108
ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasiasQ36565533
WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancerQ36602135
Wnt/beta-catenin signaling in cancer stemness and malignant behaviorQ36738603
Estrogen-related cancer microenvironment of breast carcinomaQ37170662
Mammary involution and breast cancer risk: transgenic models and clinical studiesQ37220983
Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 miceQ37553149
Mechanisms of estrogen receptor-α upregulation in breast cancersQ37832430
Wnt signalling in murine postnatal mammary gland development.Q37868761
The different roles of ER subtypes in cancer biology and therapyQ37903655
Role of cancer-associated fibroblasts in breast cancer development and prognosisQ37967584
'Cancer associated fibroblasts'--more than meets the eye.Q38114651
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)6770-6787
P577publication date2014-08-01
P1433published inOncotargetQ1573155
P1476titleThe BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis
P478volume5

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cites work (P2860)
Q61796315Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
Q36071154Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion
Q37697114Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway
Q64124141Prioritizing predictive biomarkers for gene essentiality in cancer cells with mRNA expression data and DNA copy number profile
Q37687464Role of BCL9L in transforming growth factor-β (TGF-β)-induced epithelial-to-mesenchymal-transition (EMT) and metastasis of pancreatic cancer
Q33720889Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions.
Q42374136The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.
Q41895615The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression
Q34365654The structural basis for cancer treatment decisions
Q37437287WDR5 high expression and its effect on tumorigenesis in leukemia
Q40109238miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models.