2‐Methoxystypandrone represses RANKL‐mediated osteoclastogenesis by down‐regulating formation of TRAF6–TAK1 signalling complexes

scientific article published on September 1, 2010

2‐Methoxystypandrone represses RANKL‐mediated osteoclastogenesis by down‐regulating formation of TRAF6–TAK1 signalling complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2010.00823.X
P953full work available at URLhttps://europepmc.org/articles/pmc2989585?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20735418/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20735418/pdf/?tool=EBI
https://europepmc.org/articles/PMC2989585
https://europepmc.org/articles/PMC2989585?pdf=render
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.2010.00823.x
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2010.00823.x
https://doi.org/10.1111/j.1476-5381.2010.00823.x
P932PMC publication ID2989585
P698PubMed publication ID20735418
P5875ResearchGate publication ID45826780

P2093author name stringC. C. Chen
C. Y. Huang
J. F. Liao
W. F. Chiou
P2860cites workThe kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayQ22009096
TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaBQ24307620
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6Q24537518
RANK is essential for osteoclast and lymph node developmentQ24598872
8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3Q24632804
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinaseQ28137640
Bone resorption by osteoclastsQ28145169
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesisQ28267970
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinaseQ28278061
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cellsQ28506839
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Osteoclast differentiation and activationQ29547556
Genetic regulation of osteoclast development and functionQ29617421
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Proteinases in bone resorption: obvious and less obvious roles.Q33838178
Differentiation and function of osteoclastsQ35113943
Signal transduction by receptor activator of nuclear factor kappa B in osteoclastsQ35126799
How proteases regulate bone morphogenesisQ35157756
Roles for NF-kappaB and c-Fos in osteoclastsQ36177501
RANKing intracellular signaling in osteoclastsQ36191485
Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bonesQ36316526
Fos/AP-1 proteins in bone and the immune systemQ36324940
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
Podosome and sealing zone: specificity of the osteoclast modelQ36424995
The molecular understanding of osteoclast differentiationQ36650749
The role of NFAT in osteoclast formationQ37033696
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP).Q37302319
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulatorQ38363724
Autoamplification of NFATc1 expression determines its essential role in bone homeostasisQ42972503
Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analoguesQ43807594
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast functionQ44072080
Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradationQ44398373
Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungiQ44989505
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin.Q53959402
Induction of DC-STAMP by Alternative Activation and Downstream Signaling MechanismsQ57675118
NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1Q57675122
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
Bone and haematopoietic defects in mice lacking c-fosQ58326969
Interfering with bone remodellingQ59083003
Bianthrones from Senna longiracemosaQ104390991
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)321-335
P577publication date2010-09-01
P1433published inBritish Journal of PharmacologyQ919631
P1476title2-Methoxystypandrone represses RANKL-mediated osteoclastogenesis by down-regulating formation of TRAF6-TAK1 signalling complexes
2‐Methoxystypandrone represses RANKL‐mediated osteoclastogenesis by down‐regulating formation of TRAF6–TAK1 signalling complexes
P478volume161

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cites work (P2860)
Q35099825(+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation
Q350514652-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase
Q36801757A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study
Q57493373Low-intensity pulsed ultrasound inhibits RANKL-induced osteoclast formation via modulating ERK-c-Fos-NFATc1 signaling cascades
Q92062969Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-κB and Akt signalling
Q36147283Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption?

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