SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

scientific article

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1189/JLB.3MA0114-034RR
P932PMC publication ID4197566
P698PubMed publication ID25001863

P50authorCandice M BrownQ74334070
Vidula VachharajaniQ42398906
P2093author name stringXianfeng Wang
Charles E McCall
Barbara K Yoza
Nancy L Buechler
Tiefu Liu
Jonathan David Wells
P2860cites workAfter Xigris, researchers look to new targets to combat sepsisQ44161242
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Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brainQ48930604
Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults.Q52649064
The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodesQ56926302
The search for effective therapy for sepsis: back to the drawing board?Q57151020
Leukocyte-endothelial cell interactions in diabetic retina after transient retinal ischemiaQ74217849
Depletion of dendritic cells, but not macrophages, in patients with sepsisQ77671545
Injury of the blood brain barrier and up-regulation of icam-1 in polymicrobial sepsisQ80420788
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsisQ84255932
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseQ24293656
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammationQ24682128
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismQ27679007
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activityQ28484104
Macrophages, inflammation, and insulin resistanceQ29614351
The pathophysiology and treatment of sepsisQ29619103
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsisQ33749945
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticityQ34247997
NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.Q34281758
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disordersQ34351149
Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistanceQ34578490
Endotoxin tolerance-current concepts in historical perspectiveQ34655790
NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin toleranceQ34684804
The role of the endothelium in severe sepsis and multiple organ dysfunction syndromeQ35051545
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishmentQ35113561
Endotoxin tolerance: is there a clinical relevance?Q35153199
SirT1 regulates adipose tissue inflammationQ35561122
Neutrophils use both shared and distinct mechanisms to adhere to selectins under static and flow conditionsQ35764552
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brainQ35784810
Immunosuppression in patients who die of sepsis and multiple organ failureQ35991015
Fueling the flame: bioenergy couples metabolism and inflammationQ36188905
TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.Q36260870
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscleQ36739504
Biomarkers of endothelial cell activation in early sepsisQ36894829
The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin toleranceQ37459848
Gene-Specific Epigenetic Regulation in Serious Infections with Systemic InflammationQ37781968
Sepsis-induced intestinal microvascular and inflammatory responses in obese mice.Q38288833
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion.Q40752165
The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for P- and E-selectinsQ41346155
Immunotherapy for sepsis--a new approach against an ancient foe.Q42802907
Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?Q43461783
Blood-brain barrier derangement in sepsis: cause of septic encephalopathy?Q43688196
P433issue5
P921main subjectsepsisQ183134
P304page(s)785-796
P577publication date2014-07-07
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleSIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
P478volume96

Reverse relations

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