NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients

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NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...740070S
P356DOI10.1371/JOURNAL.PONE.0040070
P932PMC publication ID3394787
P698PubMed publication ID22808091
P5875ResearchGate publication ID229162137

P2093author name stringRuud M Buijs
Gian-Luca Ferri
Carolina Escobar
Roberto Salgado-Delgado
Laura Chávez-Macías
Nadia Saderi
Maria del Carmen Basualdo
Juan E Olvera Roblera
Rafael Avendaño-Pradel
P2860cites workTargeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balanceQ28504621
VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesityQ28507438
Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medullaQ28570756
VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fastingQ28587343
Topography and associations of luteinizing hormone-releasing hormone and neuropeptide Y-immunoreactive neuronal systems in the human diencephalon.Q30952962
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neuronsQ33604542
A brain-liver circuit regulates glucose homeostasisQ34438321
Studies on the physiological functions of the melanocortin systemQ36640631
VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkersQ37881441
Immunocytochemical localization of pro-opiomelanocortin neurons in human brain areas subserving stimulation analgesiaQ39532786
Immunohistochemical localization of alpha-melanocyte stimulating hormone (α-MSH) in the human hypothalamusQ39617601
Metabolic effects of neuropeptide Y injections into the paraventricular nucleus of the hypothalamusQ42637070
Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitusQ43512312
Hypothalamic insulin signaling is required for inhibition of glucose productionQ44212603
Opioid precursor gene expression in the human hypothalamusQ44335103
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptidesQ44995522
Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetesQ44995539
Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulinQ45077923
Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstemQ46801024
Role of brain insulin receptor in control of body weight and reproductionQ47229086
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose productionQ48145978
Corticotropin-releasing hormone neurons in hypertensive patients are activated in the hypothalamus but not in the brainstemQ48178777
Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?Q48294248
Differential expression and seasonal modulation of VGF peptides in sheep pituitary.Q48820761
Human brainstem catecholamine neuronal anatomy as indicated by immunocytochemistry with antibodies to tyrosine hydroxylaseQ48857611
Glucose and osmosensitive neurones of the rat hypothalamusQ49037265
Comparative immunohistochemical study of the distribution of neuropeptide Y, growth hormone-releasing factor and the carboxyterminus of precursor protein GHRF in the human hypothalamic infundibular areaQ49045074
Increased hypothalamic neuropeptide Y expression following food deprivationQ50138663
ACTIVITY OF SINGLE NEURONS IN THE HYPOTHALAMIC FEEDING CENTERS: EFFECT OF GLUCOSE.Q51267621
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action.Q51573255
Distribution of monoamine-synthesizing neurons in the human medulla oblongataQ59544723
The distribution of neuropeptide Y-like immunoreactive neurons in the human medulla oblongataQ59544726
Immunocytochemical localization of neuropeptide Y (NPY) in the human hypothalamusQ62031381
Some acute effects of intracerebroventricular neuropeptide Y on insulin secretion and glucose metabolism in the ratQ71618373
Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose utilizationQ72612577
Glucoreceptors Controlling Feeding and Blood Glucose: Location in the HindbrainQ72896651
Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjectsQ77617399
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e40070
P577publication date2012-07-11
P1433published inPLOS OneQ564954
P1476titleNPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients
P478volume7

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cites work (P2860)
Q35113488Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low-density lipoprotein triglyceride secretion via sympathetic innervation
Q39852735Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects
Q29248275Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms
Q35839843VGF Peptide Profiles in Type 2 Diabetic Patients' Plasma and in Obese Mice

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