review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Keigo Machida | Q41371039 |
P2093 | author name string | Hidekazu Tsukamoto | |
Hasmik Mkrtchyan | |||
Alla Dynnyk | |||
P2860 | cites work | Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival | Q24653078 |
Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3 | Q27477554 | ||
Involvement of the PA28 -Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core Protein | Q27478049 | ||
Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog | Q27487860 | ||
Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status | Q28273212 | ||
Higher neutrophil infiltration mediated by osteopontin is a likely contributing factor to the increased susceptibility of females to alcoholic liver disease | Q28294082 | ||
An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen | Q28361995 | ||
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
Steatohepatitis: a tale of two "hits"? | Q29547771 | ||
Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat. | Q33911610 | ||
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig | Q34099028 | ||
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. | Q34174938 | ||
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. | Q34463769 | ||
Role of malondialdehyde-acetaldehyde adducts in liver injury | Q34528016 | ||
Methionine synthase. a possible prime site of the ethanolic lesion in liver | Q34635551 | ||
Role of abnormal methionine metabolism in alcoholic liver injury | Q34774377 | ||
Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil | Q35074091 | ||
Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. | Q35781449 | ||
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance | Q36484059 | ||
The role of alcoholism in hepatic iron storage disease | Q66843978 | ||
Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis | Q67971923 | ||
Effects of dietary fat on alcohol-pyrazole hepatitis in rats: the pathogenetic role of the nonalcohol dehydrogenase pathway in alcohol-induced hepatic cell injury | Q68899470 | ||
Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "low-dose" carbon tetrachloride vapor in the rat | Q70150636 | ||
Centrilobular liver necrosis induced by hypoxia in chronic ethanol-fed rats | Q70618933 | ||
Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease | Q72023092 | ||
Hepatic fibrosis produced in guinea pigs by chronic ethanol administration and immunization with acetaldehyde adducts | Q72210597 | ||
The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats | Q72418400 | ||
Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration | Q72837065 | ||
Ethanol-altered liver-associated T cells mediate liver injury in rats administered Concanavalin A (Con A) or lipopolysaccharide (LPS) | Q73152982 | ||
Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha | Q73670579 | ||
Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats | Q74522230 | ||
Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat | Q77619522 | ||
Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5 | Q79788237 | ||
Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation | Q81294978 | ||
Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver | Q83182716 | ||
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury | Q36645721 | ||
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice | Q36688699 | ||
Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis | Q36877259 | ||
Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet | Q36925263 | ||
Endoplasmic reticulum stress and liver injury | Q36989688 | ||
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver | Q37001200 | ||
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1 | Q37111703 | ||
Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice | Q37139288 | ||
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury | Q38291198 | ||
Leptin deficiency enhances sensitivity of rats to alcoholic steatohepatitis through suppression of metallothionein | Q38335556 | ||
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice | Q38354947 | ||
Zinc metabolism in alcoholic liver disease | Q39757000 | ||
Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics | Q39765074 | ||
Relationship of ethanol to choline metabolism in the liver: a review | Q39900423 | ||
Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease | Q40010594 | ||
Effects of triglyceride on ER stress and insulin resistance | Q40080488 | ||
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. | Q40474758 | ||
Regulation of hepatic microsomal cytochrome P450IIE1 level by dietary lipids and carbohydrates in rats | Q41187799 | ||
Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis | Q41349177 | ||
Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury | Q41708777 | ||
Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats | Q42518667 | ||
The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis | Q42879983 | ||
Experimental liver cirrhosis induced by alcohol and iron | Q42929412 | ||
Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis | Q42977104 | ||
Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis | Q43031864 | ||
Gender differences in pharmacokinetics of alcohol | Q43592740 | ||
Liver necrosis induced by thyroid hormone administration in rats fed ethanol | Q43705073 | ||
Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage | Q44042283 | ||
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin | Q44298573 | ||
Ethanol-induced liver fibrosis in rats fed high fat diet | Q44542773 | ||
Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase | Q44632307 | ||
Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen | Q45264409 | ||
Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis | Q45733913 | ||
Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury | Q46090988 | ||
Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages | Q46362946 | ||
Experimental hepatitis induced by ethanol after immunization with acetaldehyde adducts | Q46461084 | ||
Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice | Q46488022 | ||
A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury | Q46701446 | ||
Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol | Q46734486 | ||
IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. | Q46747521 | ||
S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. | Q46818781 | ||
Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. | Q50952813 | ||
Endotoxin induced hepatic necrosis in rats on an alcohol diet. | Q54765276 | ||
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma | Q62727088 | ||
P433 | issue | 2 | |
P304 | page(s) | 178-187 | |
P577 | publication date | 2009-04-22 | |
P1433 | published in | Seminars in Liver Disease | Q15724477 |
P1476 | title | "Second hit" models of alcoholic liver disease | |
P478 | volume | 29 |
Q37899945 | A systems biology approach for understanding the collagen regulatory network in alcoholic liver disease |
Q35117523 | Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. |
Q41837978 | Alcohol Vapor Inhalation as a Model of Alcohol-Induced Organ Disease. |
Q35660303 | Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage |
Q64922947 | Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects. |
Q42023633 | Alcoholic Liver Disease: Pathogenesis and Current Management |
Q27000153 | Alcoholic and non-alcoholic steatohepatitis |
Q38759707 | Alcoholic hepatitis: Translational approaches to develop targeted therapies |
Q38209601 | Alcoholic hepatitis: current management |
Q37823647 | Alcoholic liver disease and exacerbation by malnutrition and infections: what animal models are currently available? |
Q27690220 | Alcoholic liver disease: pathogenesis and new therapeutic targets |
Q92007574 | Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview |
Q90097440 | Animal models of drug-induced liver injury |
Q33626594 | Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges |
Q57093136 | Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients |
Q40012493 | Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response |
Q34499095 | Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model |
Q37721854 | Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients |
Q42764666 | Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease |
Q36149832 | Ethanol and hepatitis C virus suppress peptide-MHC class I presentation in hepatocytes by altering proteasome function |
Q35886275 | FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice |
Q38570690 | Host homeostatic responses to alcohol-induced cellular stress in animal models of alcoholic liver disease |
Q34163926 | Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3 |
Q28382981 | Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model |
Q38595071 | Molecular basis of alcoholic fatty liver disease: From incidence to treatment |
Q33757267 | New therapeutic targets in alcoholic hepatitis |
Q38550320 | Notch signaling and M1 macrophage activation in obesity-alcohol synergism |
Q34860648 | Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice. |
Q37011836 | Pathogenesis and Management of Alcoholic Liver Disease |
Q36395131 | Rodent models of alcoholic liver disease: of mice and men. |
Q28086898 | Role of farnesoid X receptor and bile acids in alcoholic liver disease |
Q34981610 | Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. |
Q38235454 | The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target |
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