Loop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade

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Loop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0040786
P932PMC publication ID3399832
P698PubMed publication ID22815819
P5875ResearchGate publication ID229427821

P50authorElena PapaleoQ37378300
P2093author name stringMarco Vanoni
Luca De Gioia
Paola Coccetti
Nicola Casiraghi
Alberto Arrigoni
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Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78Q27646351
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Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression.Q40140650
Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chainsQ42067617
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The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2.Q42720645
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Alternative allosteric mechanisms can regulate the substrate and E2 in SUMO conjugationQ47582802
Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7.Q47592623
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A performance enhanced PSI-BLAST based on hybrid alignmentQ48169033
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An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in Cdc34-like enzymesQ28478315
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One-thousand-and-one substrates of protein kinase CK2?Q29615345
Essential dynamics of proteinsQ29616843
Building ubiquitin chains: E2 enzymes at workQ29619578
Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylationQ30168286
Taxonomy and conformational analysis of loops in proteins.Q30350131
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Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugationQ33319924
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Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligasesQ33665546
A mechanistic view of the role of E3 in sumoylationQ33701607
Anisotropy of fluctuation dynamics of proteins with an elastic network modelQ33931550
Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylationQ34032707
Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.Q34090989
Constructing and decoding unconventional ubiquitin chains.Q34182233
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Scoring residue conservationQ34733455
Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.Q34904359
The emerging complexity of protein ubiquitinationQ35002957
E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.Q35065158
Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.Q35378702
Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitinationQ35562631
Dynamic requirements for a functional protein hingeQ36388178
Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domainsQ36555375
Structural and electrostatic properties of ubiquitination and related pathwaysQ36813750
The spatial and temporal organization of ubiquitin networksQ36844591
What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?Q37215638
Targeting the SUMO E2 conjugating enzyme Ubc9 interaction for anti-cancer drug designQ37370135
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)e40786
P577publication date2012-07-18
P1433published inPLOS OneQ564954
P1476titleLoop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade
P478volume7

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cites work (P2860)
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