Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms

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Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2125.1994.TB04242.X
P932PMC publication ID1364713
P698PubMed publication ID8148222
P5875ResearchGate publication ID15051478

P50authorAdrián LlerenaQ56419301
P2093author name stringLindström L
Bertilsson L
Dahl ML
Bondesson U
P2860cites workA family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.Q33667784
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazineQ34048732
Polymorphic hydroxylation of Debrisoquine in man.Q34057031
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoinQ34241704
Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4Q35275118
Clozapine. A novel antipsychotic agentQ36485618
Clozapine. A review of its pharmacological properties, and therapeutic use in schizophreniaQ38037996
Genetically variable metabolism of antidepressants and neuroleptic drugs in man.Q40710734
Role of genetic polymorphism in psychopharmacology--an updateQ40840711
Evidence for a role of haloperidol-sensitive sigma-'opiate' receptors in the motor effects of antipsychotic drugsQ41773246
Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humansQ43607538
Determination of clozapine and its N-demethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detectionQ43794493
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylationQ48183426
Is the sigma opiate receptor a proadifen-sensitive subform of cytochrome P-450?Q48944016
The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteinsQ49113663
SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorpan and σ ligands to guinea pig brainQ53867774
Haloperidol disposition is dependent on debrisoquine hydroxylation phenotypeQ57586064
Exchange of aromatically bound halogen for OH- and SCH3-groups in metabolising clozapine in the human organism (author's transl)Q67022219
Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detectionQ67550135
Clozapine treatment of schizophrenic patients. Plasma concentration and coagulation factorsQ67553978
Polymorphic debrisoquin hydroxylation in 757 Swedish subjectsQ67928181
Clinical pharmacokinetics of clozapine in chronic schizophrenic patientsQ67989786
The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6Q68071363
Multiple-dose pharmacokinetics of clozapine in patientsQ68853598
S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquinQ69610224
Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beingsQ69649340
Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and ageQ69795312
Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotypeQ70123367
Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in manQ70219763
The metabolism of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e) (1,4)diazepine (clozapine) in mice, dogs and human subjectsQ70707284
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)71-74
P577publication date1994-01-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleDisposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
P478volume37

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cites work (P2860)
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