Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair

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Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair is …
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scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2010.100060
P932PMC publication ID2993279
P698PubMed publication ID20971735
P5875ResearchGate publication ID47534531

P2093author name stringQun Wang
Xinping Zhang
Ming Xue
Fanjie Zeng
Chunlan Huang
P2860cites workEvidence for the direct involvement of {beta}TrCP in Gli3 protein processingQ24299566
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationQ24600279
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitroQ24675778
Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healingQ27307639
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signalingQ28141240
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationQ28206100
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferationQ28211798
WNT antagonist, SFRP1, is Hedgehog signaling targetQ28285125
Tissue repair and stem cell renewal in carcinogenesisQ28294006
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationQ28507411
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeletonQ28508641
Sequential roles of Hedgehog and Wnt signaling in osteoblast developmentQ28509123
Altered neural cell fates and medulloblastoma in mouse patched mutantsQ28588056
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signalingQ28593888
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse nodeQ28594387
Developmental roles and clinical significance of hedgehog signalingQ29614988
BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis.Q31028194
Developmental patterns of cartilageQ33753636
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.Q34345061
SSEA-4 identifies mesenchymal stem cells from bone marrowQ34576375
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repairQ34792085
Activation of heterotrimeric G proteins by SmoothenedQ35033814
Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.Q35077692
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular boneQ35748648
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineeringQ35924333
Periosteum: biology, regulation, and response to osteoporosis therapies.Q35948130
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone developmentQ36010744
Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapiesQ36516168
Regulation of chondrogenesis and chondrocyte differentiation by stress.Q37075891
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinaseQ37125235
COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healingQ37172205
Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.Q37172210
A perspective: engineering periosteum for structural bone graft healing.Q37176129
Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.Q37278490
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signallingQ37348019
Wnt pathway, an essential role in bone regenerationQ37363892
Mouse patched1 controls body size determination and limb patterning.Q38320172
Normal and heterotopic periosteumQ38608875
Purifying the hedgehog protein and its variantsQ38889017
Sonic hedgehog gene-enhanced tissue engineering for bone regenerationQ39699004
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.Q40129364
Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2.Q40696710
Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formationQ40856255
BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells.Q40873621
Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formationQ41121069
Does adult fracture repair recapitulate embryonic skeletal formation?Q41691669
Transducing Hedgehog: the story so farQ42457520
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and functionQ42530363
smoothened encodes a receptor-like serpentine protein required for hedgehog signallingQ42633905
Common molecular pathways in skeletal morphogenesis and repairQ43480213
A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.Q44376589
Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathwayQ46140707
Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skinQ46574974
Biological effects of rAAV-caAlk2 coating on structural allograft healing.Q46618116
Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cellsQ46765570
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.Q48199490
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.Q52002102
Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.Q52119170
Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair.Q52186712
Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts.Q52195082
Gene expression in older rats with delayed union of femoral fractures.Q54765249
Expression and distribution of transcripts for sonic hedgehog in the early phase of fracture repairQ73155762
Expression of Indian hedgehog during fracture healing in adult rat femoraQ73607731
The cell and molecular biology of fracture healingQ77902181
A novel murine segmental femoral graft modelQ80843408
Periosteal stem cells are essential for bone revitalization and repairQ81599330
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)3100-3111
P577publication date2010-10-22
P1433published inThe American Journal of PathologyQ4744259
P1476titleActivation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair
P478volume177