MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame

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MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...742034M
P356DOI10.1371/JOURNAL.PONE.0042034
P932PMC publication ID3411609
P698PubMed publication ID22870278
P5875ResearchGate publication ID230624539

P2093author name stringSteven J Berberich
Benjamin Bates
Jillian Fraser
Michael P Markey
Nicholas Wyatt
Pooja Mandke
P2860cites workhSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseQ24291829
MdmX is a substrate for the deubiquitinating enzyme USP2aQ24336863
Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilizationQ40355383
DNA damage-induced MDMX degradation is mediated by MDM2.Q40636352
Clinical implications of the p53 tumor-suppressor geneQ40865658
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potentialQ41451986
Inactivation of the p53 pathway in retinoblastoma.Q42152329
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sitesQ42419115
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.Q44521310
p53 is activated in response to disruption of the pre-mRNA splicing machinery.Q44950735
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory networkQ46721077
Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification targetQ48031061
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis.Q48789680
Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis.Q54662769
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.Q55476278
[HDMX amplification and high levels of HDMX-S splice variant are correlated with a poor prognosis in soft tissue sarcomas]Q80067621
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanismsQ24540261
Formation, regulation and evolution of Caenorhabditis elegans 3'UTRsQ24598773
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
A map of human genome variation from population-scale sequencingQ24617794
miR-148 targets human DNMT3b protein coding regionQ24642540
The microRNA.org resource: targets and expressionQ24650094
Clustal W and Clustal X version 2.0Q27860517
Prediction of plant microRNA targetsQ28219387
The miR-34 family in cancer and apoptosisQ28245865
Tumour suppression: disruption of HAUSP gene stabilizes p53Q28254102
A microRNA component of the p53 tumour suppressor networkQ28305330
Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signalingQ28477912
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
A microRNA as a translational repressor of APETALA2 in Arabidopsis flower developmentQ29618436
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Validation of MdmX as a therapeutic target for reactivating p53 in tumorsQ34209099
MiR-34, SIRT1 and p53: the feedback loopQ34946471
MDM2 promotes ubiquitination and degradation of MDMXQ35161842
A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sitesQ35582977
Regulation of MDMX expression by mitogenic signalingQ36498007
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activityQ36732343
The guardian's little helper: microRNAs in the p53 tumor suppressor networkQ37023130
Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathwayQ37627089
Regulation of MDM4.Q37825197
The impact of miRNA target sites in coding sequences and in 3'UTRsQ38336299
A critical role for noncoding 5S rRNA in regulating Mdmx stabilityQ39472408
miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemiaQ39501936
MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle.Q39538948
An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivityQ39630646
HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.Q39675744
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.Q39853212
Full-length hdmX transcripts decrease following genotoxic stressQ39949523
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrestQ39992760
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.Q40102003
Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.Q40224078
MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.Q40244145
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)e42034
P577publication date2012-08-01
P1433published inPLOS OneQ564954
P1476titleMicroRNA-34a modulates MDM4 expression via a target site in the open reading frame
P478volume7