The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells

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The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20130795
P932PMC publication ID4203943
P698PubMed publication ID25288397
P5875ResearchGate publication ID267025017

P50authorSimon FillatreauQ37340659
Erwin F. WagnerQ40012298
Sebastian BrachsQ41130030
Ursula Schlötzer-SchrehardtQ64866721
Georg SchettQ73565915
P2093author name stringElias Hobeika
Aline Bozec
Jean-Pierre David
Michael Reth
Dirk Mielenz
Ingolf Berberich
Anja Derer
Bettina Grötsch
Christiane Lang
Julia Luther
P2860cites workCommitment to the B-lymphoid lineage depends on the transcription factor Pax5Q22010683
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogeneQ28217075
AP-1 subunits: quarrel and harmony among siblingsQ28295184
Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiationQ28511315
AP-1 as a regulator of cell life and deathQ29616558
B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.Q33869680
Conserved motifs in Fos and Jun define a new class of activation domainQ33978710
Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptideQ34206164
Germinal centersQ34245271
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cellsQ34282966
Novel functions for NFκB: inhibition of bone formationQ34806538
Testing gene function early in the B cell lineage in mb1-cre miceQ35025083
Development and selection of marginal zone B cellsQ35666707
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factorsQ35736556
Maintenance of serum antibody levelsQ36072426
Fos/AP-1 proteins in bone and the immune systemQ36324940
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1Q36366273
Plasma cell ontogeny defined by quantitative changes in blimp-1 expressionQ36399312
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrowQ36404002
Stromal niches, plasma cell differentiation and survival.Q36450001
Isolation and characterization of murine fra-1: induction mediated by CD40 and surface Ig is protein kinase C dependentQ36829663
Germinal centres: role in B-cell physiology and malignancyQ37039584
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune diseaseQ37600558
The genetic network controlling plasma cell differentiationQ37933757
The diverse roles of IRF4 in late germinal center B‐cell differentiationQ38002486
Through a glass less darkly: apoptosis and the germinal center response to antigenQ38002487
Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cellsQ38308479
Elevated Fra-1 expression causes severe lipodystrophyQ39559775
The Fos-related antigen Fra-1 is an activator of bone matrix formationQ39959355
Loss of Pax5 promotes plasma cell differentiationQ40302998
Fra-1 replaces c-Fos-dependent functions in miceQ40445308
Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switchingQ40793070
Clonal selection and learning in the antibody systemQ41002744
Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fosQ41641690
Transcriptional regulation in the immune system: all roads lead to AP-1.Q41703294
Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cellsQ42717405
Fra-1 substitutes for c-Fos in AP-1-mediated signal transduction in retinal apoptosisQ43959547
Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigensQ44296985
An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain geneQ46984270
Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP.Q48515485
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.Q50900427
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cellsQ50943562
JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells.Q52017752
Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 familyQ52174175
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiationQ57675158
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1Q57675161
Receptor-specific induction of individual AP-1 components in B lymphocytesQ71682510
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiationQ80139485
A role for c-fos/activator protein 1 in B lymphocyte terminal differentiationQ81827353
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)2199-2212
P577publication date2014-10-06
P1433published inJournal of Experimental MedicineQ3186912
P1476titleThe AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells.
P478volume211

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cites work (P2860)
Q37624355BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo
Q50641090Bach2 is required for B cell and T cell memory differentiation
Q89900204Candidate silencer elements for the human and mouse genomes
Q42775112Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells
Q38947647Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms.
Q61813957FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer
Q47155047Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.
Q52565316New insights into the function of bone marrow
Q37504890Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation
Q43195532Repressing the repressor: Fra1 controls plasma cell generation
Q87145995Serum Response Factor Protects Retinal Ganglion Cells Against High-Glucose Damage
Q51041591The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment.
Q34463732The generation of antibody-secreting plasma cells.
Q38583565Transcription factors regulating B cell fate in the germinal centre.
Q96306728Transcriptional meta-analysis of regulatory B cells

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