A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor.

scientific article

A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1995PNAS...92.3769E
P356DOI10.1073/PNAS.92.9.3769
P932PMC publication ID42043
P698PubMed publication ID7731981
P5875ResearchGate publication ID15467170

P50authorYvette AkwaQ62554540
P2093author name stringE E Baulieu
P Robel
M el-Etr
R J Fiddes
P2860cites workRole of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptorsQ24322955
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Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell lineQ36864480
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Interaction of oestrogen and of physiological progesterone metabolites in the control of gonadotropin secretionQ41110017
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Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines.Q41443390
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Differential expression of gamma-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neuronsQ41515426
Pulsatile release of gonadotrophin releasing hormone (GnRH) is an intrinsic property of GT1 GnRH neuronal cell lines.Q41519548
The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory siteQ41556065
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptorsQ41612119
Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroidsQ41659918
Metabolism of Pro-Luteinizing Hormone-Releasing Hormone in Immortalized Hypothalamic Neurons*Q41667817
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesisQ41729068
Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistryQ42466660
Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complexQ43493262
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulationQ43538265
Membrane mechanism mediates progesterone stimulatory effect on LHRH release from superfused rat hypothalami in vitroQ44325857
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomesQ44467995
Different gamma-aminobutyric acid receptor subtypes are involved in the regulation of opiate-dependent and independent luteinizing hormone-releasing hormone secretionQ46584674
Pregnanolone, a metabolite of progesterone, stimulates LH-RH release: in vitro and in vivo studiesQ48169838
In vitro LHRH release from superfused hypothalamus as a function of the rat estrous cycle: effect of progesteroneQ48406516
Cross-talk between excitatory and inhibitory amino acids in the regulation of luteinizing hormone-releasing hormone secretionQ48440839
Effects of progesterone on hypothalamic and plasma LHRH.Q48515739
A Radioimmunoassay for Gonadotropin-Releasing Hormone (Gn-RH) in Serum1Q48662225
Gamma-aminobutyric acidA receptors mediate 3 alpha-hydroxy-5 alpha-pregnan-20-one-induced gonadotropin secretionQ49042941
Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitaryQ49091390
Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroidQ50801717
Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats.Q51656468
Transient expression shows ligand gating and allosteric potentiation of GABAA receptor subunitsQ60626923
In vivo release of luteinizing hormone-releasing hormone estimated with push-pull cannulae from the mediobasal hypothalami of ovariectomized, steroid-primed ratsQ67233743
A neuroglial cooperativity is required for the potentiation by 2-chloroadenosine of the muscarinic-sensitive phospholipase C in the striatumQ69503583
Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal ratsQ69566498
DNA measurement by mithramycin fluorescence in chromatin solubilized by heparinQ70531985
gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sitesQ72891898
P433issue9
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)3769-3773
P577publication date1995-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor
P478volume92

Reverse relations

cites work (P2860)
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