Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents

scientific article published on November 8, 2010

Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10720251G
P356DOI10.1073/PNAS.1009021107
P953full work available at URLhttps://europepmc.org/articles/pmc2996644?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21059932/?tool=EBI
https://europepmc.org/articles/PMC2996644
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21059932/pdf/?tool=EBI
https://europepmc.org/articles/PMC2996644?pdf=render
https://doi.org/10.1073/pnas.1009021107
https://pnas.org/doi/pdf/10.1073/pnas.1009021107
P932PMC publication ID2996644
P698PubMed publication ID21059932
P5875ResearchGate publication ID47717880

P50authorHermona SoreqQ15989736
C Linn CadieuxQ81456537
P2093author name stringIrene Cherni
Ian Puffenberger
Jacquelyn Kilbourne
Karli Kelley
Latha Kannan
Neil Robbins
Pierre-Emmanuel Garnaud
Douglas M. Cerasoli
Shane A. Kasten
Tamara C. Otto
David E. Lenz
Clarence A. Broomfield
Tsafrir S. Mor
Brian C. Geyer
Sean M. Hodgins
Zeke P. Oliver
Tony E. Reeves
Ryan R. Woods
P2860cites workRecombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoningQ24683895
Six peptide wound signals derived from a single precursor protein in Ipomoea batatas leaves activate the expression of the defense gene sporaminQ28270058
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Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesteraseQ30882412
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Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini reviewQ36692384
Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an updateQ37160820
The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathologyQ37285146
Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermathQ37398055
Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutantsQ40068841
Purification of transgenic plant-derived recombinant human acetylcholinesterase-R.Q40355007
Comparative plasma proteome analysis of lymphoma-bearing SJL miceQ40364333
Bioscavengers for the protection of humans against organophosphate toxicityQ40372121
Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promotersQ40563952
Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta).Q40623691
Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates.Q41860506
High-level expression of functional recombinant human butyrylcholinesterase in silkworm larvae by Bac-to-Bac systemQ42021307
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni).Q42056595
Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase.Q43114723
Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesteraseQ43600352
Characterization of butyrylcholinesterase antagonism of cocaine-induced hyperactivityQ43999048
Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicityQ44072269
Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pigQ44184701
Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic ModelQ44644039
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpineQ45278433
Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa.Q46403388
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitroQ46490779
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasmaQ46742699
Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramersQ46853141
Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.Q51390273
Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.Q52321064
A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.Q52552251
Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in miceQ56058104
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterizationQ56058106
Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesteraseQ70602362
Trimerization domain of the collagen tail of acetylcholinesteraseQ73214277
Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanaseQ74023875
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterasesQ74095213
Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral estersQ77333539
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compoundsQ79792445
Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesteraseQ80099485
Host-regulated disposition of mammalian AChEsQ81482933
P433issue47
P407language of work or nameEnglishQ1860
P921main subjectidentical protein bindingQ14762994
butyrylcholinesteraseQ22679015
P304page(s)20251-20256
P577publication date2010-11-08
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePlant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents
P478volume107

Reverse relations

cites work (P2860)
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