Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism

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Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0041094
P932PMC publication ID3401127
P698PubMed publication ID22911747
P5875ResearchGate publication ID230715158

P50authorBenu Brata DasQ56440979
Len NeckersQ89479068
Carole SourbierQ114883664
Yves PommierQ28320644
Ilaria Dalla RosaQ40933116
P2093author name stringHongliang Zhang
Céline Douarre
Christophe E Redon
P2860cites workDNA topoisomerases: structure, function, and mechanismQ22065417
Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and functionQ24313071
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1Q24320257
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleusQ24535778
Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesisQ24561539
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Selective degradation of mitochondria by mitophagyQ24658163
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4Q24670840
Autophagy: molecular machinery for self-eatingQ24678361
On the Origin of Cancer CellsQ27861025
A ubiquitin-like system mediates protein lipidationQ27934137
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.Q40933142
Ionizing radiation stimulates mitochondrial gene expression and activityQ40996508
Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescenceQ44174532
A truncated form of DNA topoisomerase IIβ associates with the mtDNA genome in mammalian mitochondriaQ44602456
SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.Q44889102
Retrograde regulation due to mitochondrial dysfunction may be an important mechanism for carcinogenesisQ46499387
Oxidative stress: role of mitochondria and protection by glutathioneQ47707173
Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling.Q48477235
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.Q53588264
Mitochondrial DNA mutations in disease and aging.Q55052993
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesQ28241500
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substratesQ28579026
SLP-2 is required for stress-induced mitochondrial hyperfusionQ28594182
GammaH2AX and cancerQ29614974
Topoisomerase I inhibitors: camptothecins and beyondQ29614976
Autophagy and metabolismQ29615974
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.Q29616569
Transcriptional paradigms in mammalian mitochondrial biogenesis and functionQ29619590
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activationQ33330300
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sitesQ33589782
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseQ33756066
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerasesQ33832261
Human mitochondrial topoisomerase IQ33943662
Fatty acid oxidation disordersQ34112648
Mitochondrial diseaseQ34543745
Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disordersQ34653971
Nuclear activators and coactivators in mammalian mitochondrial biogenesisQ34657768
Assessing mitochondrial dysfunction in cells.Q34793639
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvationQ35064216
Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.Q35174664
Transcriptional regulatory circuits controlling mitochondrial biogenesis and functionQ35683727
Mitochondrial signaling: the retrograde responseQ35739853
DNA damage responses to oxidative stressQ35848526
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasisQ35951468
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress.Q36032328
Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancerQ36048239
The role of autophagy in cancer development and response to therapy.Q36251939
Initiation and beyond: multiple functions of the human mitochondrial transcription machineryQ36692560
Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA.Q37001842
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesisQ38324237
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cellsQ40232298
Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cellsQ40351962
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.Q40531832
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)e41094
P577publication date2012-07-20
P1433published inPLOS OneQ564954
P1476titleMitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism
P478volume7

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cites work (P2860)
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Q34375948Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage

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