Imparting exquisite specificity to peanut agglutinin for the tumor-associated Thomsen-Friedenreich antigen by redesign of its combining site

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Imparting exquisite specificity to peanut agglutinin for the tumor-associated Thomsen-Friedenreich antigen by redesign of its combining site is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.35.21209
P698PubMed publication ID8702892

P2093author name stringSharma V
Surolia A
Vijayan M
P2860cites workCrystal structure of peanut lectin, a protein with an unusual quaternary structureQ24562169
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complexQ27732808
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
Tissue- and Species-Specific Expression of sp56, a Mouse Sperm Fertilization ProteinQ28513630
Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptorsQ34236758
Enzyme-linked PNA lectin binding assay compared with CA19-9 and CEA radioimmunoassay as a diagnostic blood test for pancreatic cancerQ36466555
Interaction of peanut agglutinin with normal human lymphocytes and with leukemic cellsQ37312642
Lectins as cell recognition moleculesQ38294576
Cloning by genomic PCR and production of peanut agglutinin in Escherichia coliQ38303296
Analysis of sequence variation among legume lectins. A ring of hypervariable residues forms the perimeter of the carbohydrate-binding siteQ38323720
Further characterization of the saccharide specificity of peanut (Arachis hypogaea) agglutininQ38334673
Radioiodinated peanut lectin: a potential radiopharmaceutical for immunodetection of carcinoma expressing the T antigenQ38354964
Immunochemical studies on the specificity of the peanut (Arachis hypogaea) agglutininQ38359318
Separation of mouse thymocytes into two subpopulations by the use of peanut agglutininQ39112239
Lectin-carbohydrate complexes of plants and animals: an atomic viewQ40832108
Expression of PNA-binding sites on specific glycoproteins by human melanoma cells is associated with a high metastatic potentialQ41490659
Monoclonal antibodies directed to the blood group A associated structure, galactosyl-A: specificity and relation to the Thomsen-Friedenreich antigenQ42212443
The amino acid sequence of peanut agglutininQ42627434
Peanut lectin binding properties of germinal centres of mouse lymphoid tissue.Q52851284
Identification of peanut agglutinin receptors related to the state of tumoral liver cell differentiationQ53493399
Carbohydrate-binding specificity of the so-called galactose-specific phytohemagglutininsQ67292610
T and Tn, general carcinoma autoantigensQ71372455
Modification by site-directed mutagenesis of the specificity of Erythrina corallodendron lectin for galactose derivatives with bulky substituents at C-2Q72911910
P433issue35
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)21209-21213
P577publication date1996-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleImparting exquisite specificity to peanut agglutinin for the tumor-associated Thomsen-Friedenreich antigen by redesign of its combining site
P478volume271

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cites work (P2860)
Q27631038Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry and crystal packing directed by interactions at the combining site
Q37225998Differential expression of the cancer associated antigens T (Thomsen-Friedenreich) and Tn to the skin in primary and metastatic carcinomas
Q74066944Engineering proteins that bind to cell surface carbohydrates
Q73929171Exploring enzyme amplification to characterize specificities of protein-carbohydrate recognition
Q34919461Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment.
Q34162519Interactions of substrate with calreticulin, an endoplasmic reticulum chaperone
Q38312075Kinetics and the mechanism of interaction of the endoplasmic reticulum chaperone, calreticulin, with monoglucosylated (Glc1Man9GlcNAc2) substrate
Q38299108Mutational analysis at Asn-41 in peanut agglutinin. A residue critical for the binding of the tumor-associated Thomsen-Friedenreich antigen
Q38291975Novel interactions of complex carbohydrates with peanut (PNA), Ricinus communis (RCA-I), Sambucus nigra (SNA-I) and wheat germ (WGA) agglutinins as revealed by the binding specificities of these lectins towards mucin core-2 O-linked and N-linked gly
Q38301428Peanut (Arachis hypogaea) lectin recognizes alpha-linked galactose, but not N-acetyl lactosamine in N-linked oligosaccharide terminals.
Q35568283Recombinant Plant Lectins and Their Mutants
Q43628851Specific binding of glucose-derivatized polymers to the asialoglycoprotein receptor of mouse primary hepatocytes
Q27748913Structure of the complex of Maclura pomifera agglutinin and the T-antigen disaccharide, Galbeta1,3GalNAc
Q38349495The Structural Basis for Carbohydrate Recognition By Lectins

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