Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate

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Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002881
P932PMC publication ID3426522
P698PubMed publication ID22927817
P5875ResearchGate publication ID230749358

P50authorAlan S. PerelsonQ55719625
Jeremie GuedjQ56424041
George M. ShawQ78514357
Erica H ParrishQ114423041
Ruy M. RibeiroQ30504775
Bette KorberQ30505218
Gerald H LearnQ54541884
Beatrice H. HahnQ55293537
Tanmoy BhattacharyaQ55414889
P2093author name stringHui Li
Shuyi Wang
Mark B Stoddard
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Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseQ29619994
Course and outcome of hepatitis CQ29620057
Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infectionQ30407004
Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysisQ33592278
Estimating time since infection in early homogeneous HIV-1 samples using a poisson modelQ33727328
Quasispecies in viral persistence and pathogenesis of hepatitis C virusQ33739366
Hepatitis C virus transmission bottlenecks analyzed by deep sequencing.Q33877425
Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infectionQ33877481
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effectQ34022149
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Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: implications for treatment duration.Q35012057
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The role of cells refractory to productive infection in acute hepatitis B viral dynamicsQ35691056
Upper limits of normal for alanine aminotransferase activity in the United States populationQ35713666
Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis CQ35986301
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Long-term transmission of defective RNA viruses in humans and Aedes mosquitoesQ40488747
High-resolution phylogenetic analysis of hepatitis C virus adaptation and its relationship to disease progressionQ40685050
Replication mode and landscape topology differentially affect RNA virus mutational load and robustnessQ42059089
Modelling how ribavirin improves interferon response rates in hepatitis C virus infectionQ42989468
Visualizing hepatitis C virus infections in human liver by two-photon microscopyQ42989638
Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion productionQ42991802
Dynamics of viremia in early hepatitis C virus infectionQ42992916
Genotype 1 and global hepatitis C T-cell vaccines designed to optimize coverage of genetic diversity.Q42993927
Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirinQ43048292
From RNA to quasispecies: a DNA polymerase with proofreading activity is highly recommended for accurate assessment of viral diversityQ43048808
An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.Q43049197
The frequency distribution of spontaneous bacteriophage mutants as evidence for the exponential rate of phage reproductionQ45203828
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue8
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)e1002881
P577publication date2012-08-23
P1433published inPLOS PathogensQ283209
P1476titleQuantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate
P478volume8

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