Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M413410200
P698PubMed publication ID15746101

P50authorBichitra BiswalQ74335535
P2093author name stringConstantin G Yannopoulos
Jean Bedard
Laval Chan
Maia M Cherney
Meitian Wang
Michael N G James
Darius Bilimoria
Bichitra K Biswal
Olivier Nicolas
P2860cites workCrystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
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Processing of X-ray diffraction data collected in oscillation modeQ26778468
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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with RibonucleotidesQ27472850
Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase EnzymeQ27477662
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virusQ27486092
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active siteQ27619818
A mechanism for initiating RNA-dependent RNA polymerizationQ27630442
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymeraseQ27635562
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibitionQ27640261
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiationQ27640501
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1Q27729415
Structure of the RNA-dependent RNA polymerase of poliovirusQ27744366
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistanceQ27766086
ESPript: analysis of multiple sequence alignments in PostScriptQ27860708
Solvent content of protein crystalsQ27860807
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitisQ27860811
XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron densityQ27861034
Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotidesQ28291604
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: SulfonamidesQ42982701
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amidesQ42982707
Candidate targets for hepatitis C virus-specific antiviral therapyQ42989225
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymeraseQ43049048
Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesisQ44081160
P433issue18
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
crystal structureQ895901
3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic AcidQ27094566
P304page(s)18202-18210
P577publication date2005-03-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleCrystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
P478volume280