Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes

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Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...744472K
P356DOI10.1371/JOURNAL.PONE.0044472
P932PMC publication ID3431355
P698PubMed publication ID22952984
P5875ResearchGate publication ID230805540

P2093author name stringLiudmila Korkina
Vladimir Kostyuk
Saveria Pastore
Chiara De Luca
Daniela Lulli
Alla Potapovich
Andrea Stancato
P2860cites workOxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytesQ24297516
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Depletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidationQ46150559
The skin surface lipids of man compared with those of eighteen species of animalsQ46572192
Squalene peroxides may contribute to ultraviolet light-induced immunological effectsQ67878005
ERK1/2 regulates epidermal chemokine expression and skin inflammationQ81621941
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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
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Basic principles and emerging concepts in the redox control of transcription factorsQ28391506
Surface lipids as multifunctional mediators of skin responses to environmental stimuliQ28748742
Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivoQ33426962
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RETRACTED: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.Q34085160
The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cellsQ34238429
The tryptophan photoproduct 6-formylindolo[3,2- b ]carbazole helps genes jumpQ34276813
Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathwayQ34631001
Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor systemQ34632791
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Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.Q35829067
Signaling kinases modulated by 4-hydroxynonenal.Q35940325
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The aryl hydrocarbon receptor and lightQ36593632
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The epidermal growth factor receptor system in skin repair and inflammationQ37020092
EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytesQ37114242
Role of cAMP in mediating AHR signalingQ37326966
Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry.Q37387429
Cutaneous epidermal growth factor receptor system following ultraviolet irradiation: exploring the role of molecular mechanismsQ37787319
Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art.Q37852047
Interactions of the aryl hydrocarbon receptor with inflammatory mediators: beyond CYP1A regulationQ37852743
Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.Q39743631
G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acidQ40045987
Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgarisQ40266783
Nuclear localization of EGF receptor and its potential new role as a transcription factorQ40782527
4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibitionQ40946187
Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol.Q42279041
Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytesQ42474579
Differential roles of nitric oxide synthases in regulation of ultraviolet B light-induced apoptosisQ42479580
Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.Q42482932
Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide productionQ42536735
An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathwayQ42751005
The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesisQ42848476
Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygenQ43282825
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectsqualeneQ407560
keratinocyteQ1473931
P304page(s)e44472
P577publication date2012-08-30
P1433published inPLOS OneQ564954
P1476titlePhoto-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes
P478volume7

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cites work (P2860)
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