Rapid Access to Compound Libraries through Flow Technology: Fully Automated Synthesis of a 3-Aminoindolizine Library via Orthogonal Diversification

scientific article published on September 10, 2012

Rapid Access to Compound Libraries through Flow Technology: Fully Automated Synthesis of a 3-Aminoindolizine Library via Orthogonal Diversification is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CO300094N
P953full work available online athttps://pubs.acs.org/doi/pdf/10.1021/co300094n
P698PubMed publication ID22954105

P2093author name stringKeith James
Paul P. Lange
P2860cites workSmall Molecule Library Synthesis Using Segmented FlowQ31040075
Synthesis and analysis of combinatorial libraries performed in an automated micro reactor systemQ33202069
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.Q33262360
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Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library.Q33781586
Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methodsQ33884542
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Efficient access to new chemical space through flow--construction of druglike macrocycles through copper-surface-catalyzed azide-alkyne cycloaddition reactionsQ46092826
A novel Cu-assisted cycloisomerization of alkynyl imines: efficient synthesis of pyrroles and pyrrole-containing heterocyclesQ49308433
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Optimisation of Conditions forO-Benzyl andN-Benzyloxycarbonyl Protecting Group Removal using an Automated Flow HydrogenatorQ56952408
Synthesis and solid state study of pyridine- and pyrimidine-based fragment librariesQ63350076
Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in waterQ79164694
General and direct synthesis of 3-aminoindolizines and their analogues via Pd/Cu-catalyzed sequential cross-coupling/cycloisomerization reactionsQ79650284
Parallel synthesis in an EOF-based micro reactorQ80940044
Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper TubingQ82803045
CuAAC Macrocyclization: High Intramolecular Selectivity through the Use of Copper–Tris(triazole) Ligand ComplexesQ83989827
Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor TechnologyQ84524938
A multistep continuous-flow system for rapid on-demand synthesis of receptor ligandsQ84774090
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcombinatorial chemistryQ899212
P304page(s)570-578
P577publication date2012-09-10
P1433published inACS combinatorial scienceQ27723471
P1476titleRapid access to compound libraries through flow technology: fully automated synthesis of a 3-aminoindolizine library via orthogonal diversification
Rapid Access to Compound Libraries through Flow Technology: Fully Automated Synthesis of a 3-Aminoindolizine Library via Orthogonal Diversification
P478volume14

Reverse relations

cites work (P2860)
Q38209736Accessing new chemical entities through microfluidic systems
Q47780833Automating drug discovery
Q60063471Continuous Flow Synthesis of Urea-Containing Compound Libraries Based on the Piperidin-4-one Scaffold
Q28066266Current status and future prospects for enabling chemistry technology in the drug discovery process
Q34910444Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies
Q89834926Flow Synthesis of Biologically-Relevant Compound Libraries
Q47686191Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine.

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