Regulation of secondary metabolism in streptomycetes

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Regulation of secondary metabolism in streptomycetes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MIB.2005.02.016
P698PubMed publication ID15802254
P5875ResearchGate publication ID7934394

P2093author name stringMervyn J Bibb
P2860cites workThe mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.Q39493884
Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR familyQ39495693
In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis.Q40584907
Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensisQ40763636
P433issue2
P921main subjectsecondary metabolic processQ22274727
P304page(s)208-215
P577publication date2005-04-01
P1433published inCurrent Opinion in MicrobiologyQ15752444
P1476titleRegulation of secondary metabolism in streptomycetes
P478volume8

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cites work (P2860)
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Q48030170Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor
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Q88984472Combined Drug Resistance Mutations Substantially Enhance Enzyme Production in Paenibacillus agaridevorans
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Q38823592Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
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Q46243466Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality
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Q37571513Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
Q90055074Disclosing the Potential of the SARP-Type Regulator PapR2 for the Activation of Antibiotic Gene Clusters in Streptomycetes
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Q41508558Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2).
Q55016436Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism.
Q35891264Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024.
Q41761257Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.
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Q60920522Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus
Q34697851EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2)
Q43336245Establishment of a real-time PCR method for quantification of geosmin-producing Streptomyces spp. in recirculating aquaculture systems.
Q53178973Evaluation of antimicrobial activity of the endophytic actinomycete R18(6) against multiresistant Gram-negative bacteria.
Q28550139Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression
Q34570945Evolution of sensory complexity recorded in a myxobacterial genome
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Q43312767Exploitation of biological wastes for the production of value-added hydrolases by Streptomyces sp. MSWC1 isolated from municipal solid waste compost
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Q46029324Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.
Q43029500Gamma-butyrolactone-dependent expression of the Streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei
Q33881202GdmRIII, a TetR Family Transcriptional Regulator, Controls Geldanamycin and Elaiophylin Biosynthesis in Streptomyces autolyticus CGMCC0516.
Q38230937Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid.
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Q34127518Genetic factors that influence moenomycin production in streptomycetes
Q57838636Genetic manipulation of pathway regulation for overproduction of angucycline-like antibiotic auricin in Streptomyces aureofaciens CCM 3239
Q34465535Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces
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Q44752021Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.
Q36242137Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor
Q36224202Genome-wide identification and evaluation of constitutive promoters in streptomycetes
Q24654173Global phenotypic characterization of bacteria
Q91826825Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces
Q58196757Healing potential of aStreptomycessp. secondary metabolite, SEM-1-111, on experimental full-thickness excision cutaneous wounds in Wistar rats
Q41973362Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.
Q88228846High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain
Q35696118High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system.
Q34232884High-throughput screening for Streptomyces antibiotic biosynthesis activators
Q36702895Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy
Q42155485Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis
Q33957020Identification and characterization of a Streptomyces sp. isolate exhibiting activity against multidrug-resistant coagulase-negative Staphylococci.
Q50445092Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.
Q51664079Identification and engineering of regulation-related genes toward improved kasugamycin production.
Q36845072Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts
Q33504630Identification of a novel Streptomyces chattanoogensis L10 and enhancing its natamycin production by overexpressing positive regulator ScnRII.
Q58556442Identification of as an Activator of Morphological Development in CK-15
Q46338385Identification of different promoters in the absA1-absA2 two-component system, a negative regulator of antibiotic production in Streptomyces coelicolor
Q34312493Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis
Q42788244Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427.
Q36017875Impact of malic enzymes on antibiotic and triacylglycerol production in Streptomyces coelicolor
Q39563170Improvement of chloramphenicol production in Streptomyces venezuelae ATCC 10712 by overexpression of the aroB and aroK genes catalysing steps in the shikimate pathway.
Q36321025Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
Q39117177In vivo DNase I sensitivity of the Streptomyces coelicolor chromosome correlates with gene expression: implications for bacterial chromosome structure
Q35857660In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10.
Q35829390Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product
Q38887214Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects
Q38899652Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces
Q45929921Intracellular ATP levels affect secondary metabolite production in Streptomyces spp.
Q38165114Intriguing properties of the angucycline antibiotic auricin and complex regulation of its biosynthesis
Q33941388Isolation and characterisation of acaricidal and larvicidal novel compound (2S,5R,6R)-2-hydroxy-3,5,6-trimethyloctan-4-one from Streptomyces sp. against blood-sucking parasites
Q54790399JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis.
Q34170994LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor
Q47682121Lignin degradation: microorganisms, enzymes involved, genomes analysis and evolution.
Q40314872Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.
Q36458851Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides
Q33926357Manipulating natural product biosynthetic pathways via DNA assembler
Q38088444Marine actinobacterial metabolites: current status and future perspectives.
Q36577086Metabolic profiling as a tool for prioritizing antimicrobial compounds
Q34093270Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture
Q39841391Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids
Q37548534Microbial quorum sensing: a tool or a target for antimicrobial therapy?
Q97646470Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis
Q64166981Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline
Q34329962Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity
Q97883386Molecular Dynamics to Elucidate the DNA-Binding Activity of AlpZ, a Member of the Gamma-Butyrolactone Receptor Family in Streptomyces ambofaciens
Q51593310Molecular basis underlying LuxR family transcription factors and function diversity and implications for novel antibiotic drug targets.
Q46237083Molecular characterization of a Rhodococcus jostii RHA1 γ-butyrolactone(-like) signalling molecule and its main biosynthesis gene gblA.
Q36667387Molecular regulation of antibiotic biosynthesis in streptomyces.
Q51768794Morphology-driven downscaling of Streptomyces lividans to micro-cultivation.
Q41704518Multi-Response Optimization of Granaticinic Acid Production by Endophytic Streptomyces thermoviolaceus NT1, Using Response Surface Methodology
Q93092649Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2)
Q35879223Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2)
Q24816810Mycelium development in Streptomyces antibioticus ATCC11891 occurs in an orderly pattern which determines multiphase growth curves
Q38903306Native and engineered promoters in natural product discovery
Q38918786Natural Products and the Gene Cluster Revolution
Q34096062Natural products version 2.0: connecting genes to molecules.
Q47947096Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387.
Q48101304New Kid on the Block: LmbU Expands the Repertoire of Specialized Metabolic Regulators in Streptomyces
Q38059156New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
Q60049620Non-targeted metabolomics unravels a media-dependent prodiginines production pathway in Streptomyces coelicolor A3(2)
Q38762222Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals.
Q46848688Novel 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone isolated from terrestrial Streptomyces sp. (eri-26) with antimicrobial and molecular docking studies
Q47993512Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria
Q36769678Novel links between antibiotic resistance and antibiotic production
Q92236792Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis
Q41991512Optimal Conditions for Antimicrobial Metabolites Production from a New Streptomyces sp. RUPA-08PR Isolated from Bangladeshi Soil
Q47556057Optimization of Fermentation Conditions and Bench-Scale for Improvement of a Novel Glycoprotein GP-1 Production by Streptomyces kanasenisi ZX01.
Q35836514Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins
Q54195476PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis.
Q60046290Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor
Q42412440Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters
Q41346634PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis
Q36362439Pleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae
Q37271996Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin
Q89761495Potential of Bioremediation and PGP Traits in Streptomyces as Strategies for Bio-Reclamation of Salt-Affected Soils for Agriculture
Q84242823Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators
Q38723296Production of bioactive compounds by actinomycetes and their antioxidant properties
Q37704410Production of microbial secondary metabolites: regulation by the carbon source.
Q40825101Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus
Q57490161Purification and Characterization of Plantaricin LPL-1, a Novel Class IIa Bacteriocin Produced by LPL-1 Isolated From Fermented Fish
Q40329481Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor
Q30461869RNA-Seq and RNA immunoprecipitation analyses of the transcriptome of Streptomyces coelicolor identify substrates for RNase III
Q89043822Recent advances in activating silent biosynthetic gene clusters in bacteria
Q36319374Recent functional insights into the role of (p)ppGpp in bacterial physiology
Q35078349Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold
Q42137696Regulation of a novel gene cluster involved in secondary metabolite production in Streptomyces coelicolor.
Q58713797Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges
Q35075249Regulation of ppk expression and in vivo function of Ppk in Streptomyces lividans TK24
Q49851792Regulation of specialised metabolites in Actinobacteria - Expanding the paradigms.
Q35320651Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production
Q34192714Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens
Q33931520Regulation of valanimycin biosynthesis in Streptomyces viridifaciens: characterization of VlmI as a Streptomyces antibiotic regulatory protein (SARP).
Q51191689Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.
Q38316147Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor
Q34055944Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA.
Q52593584Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis.
Q36933804Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor
Q33401726Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027
Q96136096Role of symbiosis in the discovery of novel antibiotics
Q35827085Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP
Q42044034Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.
Q37426455SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.
Q37411971SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development
Q34549767Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch
Q55048058SbbR/SbbA, an Important ArpA/AfsA-Like System, Regulates Milbemycin Production in Streptomyces bingchenggensis.
Q37782470Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation
Q91625796Secondary metabolites overproduction through transcriptional gene cluster refactoring
Q46494798Selection of objective function in genome scale flux balance analysis for process feed development in antibiotic production
Q51335159SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus.
Q37454321Small RNA-dependent expression of secondary metabolism is controlled by Krebs cycle function in Pseudomonas fluorescens
Q35586971Soil microbiome responses to the short-term effects of Amazonian deforestation.
Q92492981Spatial structure increases the benefits of antibiotic production in Streptomyces
Q51147970Spatio-temporal dynamics of soil bacterial communities as a function of Amazon forest phenology.
Q38861928Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.
Q37831207Strain improvement in actinomycetes in the postgenomic era.
Q37751993Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters
Q47240821Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties.
Q45239926Strict control of auricin production in Streptomyces aureofaciens CCM 3239 involves a feedback mechanism
Q33669799Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145
Q35957999Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps
Q91688991Studies on Antibacterial Activity and Diversity of Cultivable Actinobacteria Isolated from Mangrove Soil in Futian and Maoweihai of China
Q35067398Subinhibitory antibiotic concentrations mediate nutrient use and competition among soil streptomyces.
Q38438599Switching antibiotics production on and off in actinomycetes by an IclR family transcriptional regulator from Streptomyces peucetius ATCC 27952.
Q30435989Synthetic promoter library for modulation of actinorhodin production in Streptomyces coelicolor A3(2).
Q36457919Taxonomy, Physiology, and Natural Products of Actinobacteria
Q44395113Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis.
Q42594237Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters
Q35228785The -omics Era- Toward a Systems-Level Understanding of Streptomyces
Q89620965The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors in Streptomyces and Related Actinobacteria
Q36990911The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba
Q28274333The biosynthesis and regulation of bacterial prodiginines
Q42095834The broad-spectrum antibiotic, zeamine, kills the nematode worm Caenorhabditis elegans.
Q46007048The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei.
Q34093836The complex extracellular biology of Streptomyces
Q38858040The evolution of genome mining in microbes - a review.
Q44077506The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.
Q38609131The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation
Q38280433The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)
Q36578862The many roles of glutamate in metabolism
Q37714912The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases
Q37713211The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size
Q41249257The multifaceted roles of antibiotics and antibiotic resistance in nature
Q43219941The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis
Q37879562The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
Q38141851The role of transcription in heterologous expression of polyketides in bacterial hosts.
Q51098507The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.
Q51705368Therapeutic treasures from the deep.
Q33516980Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins
Q54445280Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya.
Q42095473Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor
Q38012634Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor
Q38165842Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).
Q38125903Triggers and cues that activate antibiotic production by actinomycetes
Q35184909Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis
Q38172598Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
Q36724719Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
Q34549997Uncovering the cultivable microbial diversity of costa rican beetles and its ability to break down plant cell wall components
Q38164359Understanding and manipulating antibiotic production in actinomycetes
Q55384462Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.
Q36302104Using natural products for drug discovery: the impact of the genomics era.
Q42374306wblE2 transcription factor in Streptomyces griseus S4-7 plays an important role in plant protection
Q64065215β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593

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