Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels

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Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0378-4274(00)00286-1
P698PubMed publication ID11684357

P2093author name stringGervasi PG
Berthou F
Dréano Y
Le Gal A
P2860cites workInvolvement of cytochrome P450 3A4 in N-dealkylation of buprenorphine in human liver microsomesQ73408047
Oxidation of methyl- and ethyl- tertiary-butyl ethers in rat liver microsomes: role of the cytochrome P450 isoformsQ74546492
Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1Q74636443
Biotransformation of 12C- and 2-13C-labeled methyl tert-butyl ether, ethyl tert-butyl ether, and tert-butyl alcohol in rats: identification of metabolites in urine by 13C nuclear magnetic resonance and gas chromatography/mass spectrometryQ74644564
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspectsQ28322217
Health effects of oxygenated fuelsQ30499474
Biotransformation and kinetics of excretion of tert-amyl-methyl ether in humans and rats after inhalation exposureQ31387057
Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicityQ34638744
Biotransformation and kinetics of excretion of ethyl tert-butyl ether in rats and humansQ40775854
In vitro assessment of human cytochrome P450.Q40828743
Disposition, metabolism, and toxicity of methyl tertiary butyl ether, an oxygenate for reformulated gasolineQ40977607
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.Q41462331
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomesQ42966283
Rat olfactory mucosa displays a high activity in metabolizing methyl tert-butyl ether and other gasoline ethersQ48556857
Metabolism of methyl tertiary-butyl ether by rat hepatic microsomesQ68808457
Comparison of caffeine metabolism by slices, microsomes and hepatocyte cultures from adult human liverQ69661355
Determination of free acetaldehyde in blood as the dinitrophenylhydrazone derivative by high-performance liquid chromatographyQ69664611
Oxidative demethylation of t-butyl alcohol by rat liver microsomesQ71504824
Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomesQ71574477
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomesQ71610108
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liverQ72207242
Use of in vitro human metabolism studies in drug development. An industrial perspectiveQ72384534
Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomesQ72519582
Probing the active sites of rat and human cytochrome P450 2E1 with alcohols and carboxylic acidsQ72583662
High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomesQ72932514
Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humansQ73018280
Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalystQ73031761
Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human liversQ73217892
P433issue1-3
P304page(s)47-58
P577publication date2001-10-01
P1433published inToxicology LettersQ1796854
P1476titleHuman cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels
P478volume124

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cites work (P2860)
Q33224655Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis
Q42707273Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal, low active and inactive ALDH2.
Q42699876Biochemistry and occurrence of o-demethylation in plant metabolism
Q39848804Differential toxic effects of methyl tertiary butyl ether and tert-butanol on rat fibroblasts in vitro.
Q36799537Ethyl tertiary-butyl ether: a toxicological review
Q36633868Health Risk Assessment for Inhalation Exposure to Methyl Tertiary Butyl Ether at Petrol Stations in Southern China
Q43265046In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry
Q35230207Methyl tert butyl ether targets developing vasculature in zebrafish (Danio rerio) embryos
Q45339245Methyl tert-butyl ether (MTBE) detected in abnormally high concentrations in postmortem blood and urine from two persons found dead inside a car containing a gasoline spill
Q33698081Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes
Q37964573Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes
Q38594604Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites

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