Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats

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Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...746092G
P356DOI10.1371/JOURNAL.PONE.0046092
P932PMC publication ID3461004
P698PubMed publication ID23029398
P5875ResearchGate publication ID231815742

P2093author name stringLi Gao
Yingdong Zhang
Yi Liu
Teng Jiang
Jun Guo
Guiyun Cui
Lingying Su
Lize Gu
P2860cites workRole of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivoQ46910238
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioningQ48232821
Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury.Q48299811
Delayed hypoxic postconditioning protects against cerebral ischemia in the mouseQ48508982
GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.Q51891379
Proteasomal proteolysis in anoxia-reoxygenation, preconditioning and postconditioning of isolated cardiomyocytes.Q53628689
Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway.Q54644104
p62/SQSTM1: a missing link between protein aggregates and the autophagy machineryQ57271943
Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemiaQ59054547
Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell deathQ81439746
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagyQ83632609
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
TOR, a central controller of cell growthQ27933354
Induction of autophagy and inhibition of tumorigenesis by beclin 1Q28131718
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
StrokeQ28279570
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathwaysQ28573254
Autophagy: process and functionQ29547296
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cellsQ29614181
Autophagy in health and disease: a double-edged swordQ29618103
RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in ratsQ33552631
Retracted: Propofol Prevents Autophagic Cell Death following Oxygen and Glucose Deprivation in PC12 Cells and Cerebral Ischemia-Reperfusion Injury in RatsQ34235629
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Q34626231
Ischemic tolerance.Q35002089
Ischemic tolerance and endogenous neuroprotectionQ35126696
Endoplasmic reticulum stress triggers autophagyQ35690087
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injuryQ36559658
Autophagic neuron death in neonatal brain ischemia/hypoxiaQ37062794
The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathwaysQ37352314
Postconditioning in acute myocardial infarction patients.Q37767722
In vivo imaging of autophagy in a mouse stroke modelQ42866525
Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathwayQ42939406
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemiaQ43007194
Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosisQ43200917
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.Q45183594
Postischemic treatment of neonatal cerebral ischemia should target autophagy.Q45955328
Infarct size is increased in female post-MI rats treated with rapamycin.Q45969585
Bradykinin postconditioning protects pyramidal CA1 neurons against delayed neuronal death in rat hippocampusQ46101275
Autophagy is involved in the ischemic preconditioningQ46186070
Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in ratsQ46205659
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injuryQ46400463
Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat.Q46516152
Postconditioning the human heartQ46722557
Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.Q46805044
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcerebral infarctionQ1209150
autophagyQ288322
P304page(s)e46092
P577publication date2012-09-28
P1433published inPLOS OneQ564954
P1476titleInhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats
P478volume7