Morphogenesis of the Node of Ranvier: Co-Clusters of Ankyrin and Ankyrin-Binding Integral Proteins Define Early Developmental Intermediates

scientific article published on September 15, 1997

Morphogenesis of the Node of Ranvier: Co-Clusters of Ankyrin and Ankyrin-Binding Integral Proteins Define Early Developmental Intermediates is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.17-18-07025.1997
P953full work available at URLhttp://www.jneurosci.org/cgi/content/abstract/17/18/7025
https://doi.org/10.1523/jneurosci.17-18-07025.1997
https://europepmc.org/articles/PMC6573274
https://europepmc.org/articles/PMC6573274?pdf=render
https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-18-07025.1997
https://www.jneurosci.org/content/jneuro/17/18/7025.full.pdf
P932PMC publication ID6573274
P698PubMed publication ID9278538

P2093author name stringV. Bennett
S. Lambert
J. Q. Davis
P2860cites workBrain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits.Q48793742
Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of RanvierQ48831078
Sodium channels in single demyelinated mammalian axonsQ51755545
Clustering of Na+ channels and node of Ranvier formation in remyelinating axons.Q55065290
Identical point mutations of PMP-22 in Trembler-J mouse and Charcot-Marie-Tooth disease type 1AQ55671003
Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cellsQ57253842
Clustering of voltage-dependent sodium channels on axons depends on Schwann cell contactQ59095459
Ankyrin and spectrin associate with voltage-dependent sodium channels in brainQ59095499
Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelinQ68425029
Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibresQ69061419
Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchangerQ70825986
Development of axonal membrane specializations defines nodes of Ranvier and precedes Schwann cell myelin elaborationQ71360196
The clustering of axonal sodium channels during development of the peripheral nervous systemQ71394719
Aggregation of sodium channels induced by a postnatally upregulated isoform of agrinQ71574134
Hypomyelination alters K+ channel expression in mouse mutants shiverer and TremblerQ71623681
The ANK Repeats of Erythrocyte Ankyrin Form Two Distinct but Cooperative Binding Sites for the Erythrocyte Anion ExchangerQ72036870
Asymmetry currents in the mammalian myelinated nerveQ72899292
AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of RanvierQ24311821
A theory of the effects of fibre size in medullated nerveQ24543926
Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structureQ27485693
Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrinQ28285943
The L1 family of neural cell adhesion molecules: old proteins performing new tricksQ28294788
Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segmentsQ28566036
Existence of distinct sodium channel messenger RNAs in rat brainQ28566276
An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nervesQ28579175
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motifQ28579493
The agrin gene codes for a family of basal lamina proteins that differ in function and distributionQ34234963
Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascinQ34426198
Agrin-like molecules at synaptic sites in normal, denervated, and damaged skeletal musclesQ36217250
Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sitesQ36236826
Immunocytochemical localization of sodium channel distributions in the excitable membranes of Electrophorus electricusQ36319331
A new 440-kD isoform is the major ankyrin in neonatal rat brainQ36530617
440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axonsQ36534838
Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheathQ37598575
The spectrin-based membrane skeleton and micron-scale organization of the plasma membraneQ40800564
From anemia to cerebellar dysfunction. A review of the ankyrin gene familyQ40871566
Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cordQ41370103
Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerveQ41522607
Development of the axon membrane during differentiation of myelinated fibres in spinal nerve rootsQ41539234
Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brainQ42259093
Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion moleculesQ42695486
Ultrastructural features of the immature peripheral nerveQ43016266
The node of Ranvier in the central nervous systemQ43653035
Induction of sodium channel clustering by oligodendrocytesQ46198260
Three-dimensional fine structure of cytoskeletal-membrane interactions at nodes of RanvierQ46593782
Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse.Q46875791
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
avian proteinsQ75833037
P304page(s)7025-7036
P577publication date1997-09-01
1997-09-15
P1433published inJournal of NeuroscienceQ1709864
P1476titleMorphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates
Morphogenesis of the Node of Ranvier: Co-Clusters of Ankyrin and Ankyrin-Binding Integral Proteins Define Early Developmental Intermediates
P478volume17

Reverse relations

cites work (P2860)
Q28507204A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier
Q34738298A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier
Q80932207Acute demyelination disrupts the molecular organization of peripheral nervous system nodes
Q51237153Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA.
Q36328448An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction
Q41391566Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology
Q31048324Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury
Q51565790Ankyrin G expression is associated with androgen receptor stability, invasiveness, and lethal outcome in prostate cancer patients
Q37617545Ankyrin protein networks in membrane formation and stabilization
Q24685343Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
Q24682474AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing
Q34132769Ankyrins and cellular targeting of diverse membrane proteins to physiological sites
Q36251703Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms
Q37743241Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury.
Q36313415Axo-glial interactions regulate the localization of axonal paranodal proteins
Q36328416Axo-glial septate junctions. The maestro of nodal formation and myelination?
Q33650497Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier
Q45966072Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia.
Q80467956BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier
Q41866964Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier.
Q22011028Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels
Q33290469Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant
Q36323794Clustering of neuronal potassium channels is independent of their interaction with PSD-95.
Q33945987Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.
Q30447603Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses
Q28188411Contactin associates with Na+ channels and increases their functional expression
Q52134357Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve
Q52174918Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.
Q42510977Deposition of the NG2 proteoglycan at nodes of Ranvier in the peripheral nervous system.
Q34013147Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion
Q44746062Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography
Q34942239Development of nodes of Ranvier
Q46951133Differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during PNS development
Q34389405Disrupted synaptic development in the hypoxic newborn brain
Q42010808Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons.
Q24323237Early events in node of Ranvier formation during myelination and remyelination in the PNS
Q28207269FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons
Q44376585Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
Q58107241Genetic dysmyelination alters the molecular architecture of the nodal region
Q39644189Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system
Q37231051Guided exploration of genomic risk for gray matter abnormalities in schizophrenia using parallel independent component analysis with reference
Q34193048Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits
Q33244434Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trap
Q73002671Initiation of sodium channel clustering at the node of Ranvier in the mouse optic nerve
Q52168360Ion channel sequestration in central nervous system axons
Q34560911Ion transport proteins anchor and regulate the cytoskeleton
Q36323012Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier
Q37698145Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM.
Q35924084Mechanisms and roles of axon-Schwann cell interactions.
Q102389012Mechanisms of node of Ranvier assembly
Q34995041Molecular constituents of the node of Ranvier
Q34085479Molecular domains of myelinated axons
Q37273627Molecular domains of myelinated axons in the peripheral nervous system
Q37302001Molecular mechanisms of node of Ranvier formation.
Q33666278Myelination and regional domain differentiation of the axon
Q36256346Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons
Q41755566Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations
Q35044841Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier
Q57362501Neurofascin interactions play a critical role in clustering sodium channels, ankyrinG and βIV spectrin at peripheral nodes of Ranvier
Q78795197Nodal sodium channel domain integrity depends on the conformation of the paranodal junction, not on the presence of transverse bands
Q34558317Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons.
Q28582251Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms
Q34500816Nodes of Ranvier come of age.
Q34657208Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes
Q77307241Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier
Q48895120Nr-CAM expression in the developing mouse nervous system: ventral midline structures, specific fiber tracts, and neuropilar regions
Q33726825Organization and maintenance of molecular domains in myelinated axons
Q34275361Organizing principles of the axoglial apparatus
Q35510088Paranodal myelin retraction in relapsing experimental autoimmune encephalomyelitis visualized by coherent anti-Stokes Raman scattering microscopy
Q38020957Pathogenic and physiological autoantibodies in the central nervous system
Q35042867Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.
Q35558428Polarized domains of myelinated axons.
Q30837291Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function
Q37010706Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G.
Q26766627Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons
Q34321652Regulation of Na+ channel distribution in the nervous system
Q89120913Reorganization of Destabilized Nodes of Ranvier in βIV Spectrin Mutants Uncovers Critical Timelines for Nodal Restoration and Prevention of Motor Paresis
Q28566467Restriction of 480/270-kD Ankyrin G to Axon Proximal Segments Requires Multiple Ankyrin G-specific Domains
Q36324587Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
Q33707595Schwann cells and their precursors emerge as major regulators of nerve development
Q36119690Secreted gliomedin is a perinodal matrix component of peripheral nerves
Q55360507Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.
Q24685559Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain
Q24291372Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues
Q38364754Subcellular patterning: axonal domains with specialized structure and function.
Q24669523Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation
Q28594823The Effect of the Mouse MutationClaw Pawon Myelination and Nodal Frequency in Sciatic Nerves
Q52167693The L1-type cell adhesion molecule neuroglian influences the stability of neural ankyrin in the Drosophila embryo but not its axonal localization.
Q38583864The Nodes of Ranvier: Molecular Assembly and Maintenance
Q24299302The Role of the Ankyrin-Binding Protein NrCAM in Node of Ranvier Formation
Q37333152The actin cytoskeleton in endothelial cell phenotypes
Q21560854The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention
Q36514764The distribution and targeting of neuronal voltage-gated ion channels
Q36328347The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr)
Q37288431The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM function
Q22337224The local differentiation of myelinated axons at nodes of Ranvier
Q38119786The making of a node: a co-production of neurons and glia
Q24290724The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity
Q33851812The peripheral myelin protein 22 and epithelial membrane protein family
Q37969855The role of NrCAM in neural development and disorders—Beyond a simple glue in the brain
Q37776425The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life
Q28579926Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes
Q46503296Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation.
Q34479857Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
Q28574440Voltage-gated sodium channels and ankyrinG occupy a different postsynaptic domain from acetylcholine receptors from an early stage of neuromuscular junction maturation in rats
Q24652657[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier
Q36117801betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG.
Q24290541betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system

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