Structure-based design of NS2 mutants for attenuated influenza A virus vaccines

scientific article published on October 21, 2010

Structure-based design of NS2 mutants for attenuated influenza A virus vaccines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIRUSRES.2010.10.014
P953full work available at URLhttps://europepmc.org/articles/pmc3010430?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20970464/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20970464/pdf/?tool=EBI
https://europepmc.org/articles/PMC3010430
https://europepmc.org/articles/PMC3010430?pdf=render
https://doi.org/10.1016/j.virusres.2010.10.014
https://api.elsevier.com/content/article/PII:S0168170210003734?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0168170210003734?httpAccept=text/xml
P932PMC publication ID3010430
P698PubMed publication ID20970464
P5875ResearchGate publication ID47533262

P50authorYoshihiro KawaokaQ2600945
Kiyoko Iwatsuki-HorimotoQ66750947
Hatice AkarsuQ73933255
Florence BaudinQ100395020
Eiryo KawakamiQ103806765
P2093author name stringTakeshi Noda
Taisuke Horimoto
Hiroaki Katsura
P2860cites workThe gene structure and replication of influenza virusQ22255660
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cellsQ27469379
Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomerQ27629317
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)Q27642013
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1Q27738409
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
In vitro dissection of the membrane and RNP binding activities of influenza virus M1 proteinQ27863692
Assembly and budding of influenza virusQ27863797
Nuclear traffic of influenza virus proteins and ribonucleoprotein complexesQ27864127
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypesQ27865187
Molecular assembly of influenza virus: association of the NS2 protein with virion matrixQ27865315
The multifunctional NS1 protein of influenza A virusesQ28294201
Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadineQ28367584
Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.Q28609759
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transportQ28609810
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genomeQ28646335
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
Large-scale sequence analysis of avian influenza isolates.Q30352711
Transcription-inhibition and RNA-binding domains of influenza A virus matrix protein mapped with anti-idiotypic antibodies and synthetic peptidesQ30452201
Association of influenza virus matrix protein with ribonucleoproteinsQ33706147
Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particlesQ33730979
Role of the influenza virus M1 protein in nuclear export of viral ribonucleoproteinsQ33797502
Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shapeQ33886239
The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteinsQ33888022
Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 proteinQ33914921
Influenza A virus-generated small RNAs regulate the switch from transcription to replicationQ33953132
Engineered RNA viral synthesis of microRNAsQ33953313
Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is uniqueQ34099139
The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assemblyQ34648238
Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1Q34685189
Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 proteinQ35131981
Influenza virus targets the mRNA export machinery and the nuclear pore complexQ35629429
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAsQ35837862
Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not influence viral replication in ducksQ35891622
Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1.Q36378896
Influenza virus NS1 protein stimulates translation of the M1 protein.Q36628590
A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicityQ36670254
Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells.Q36902228
The smallest genome RNA segment of influenza virus contains two genes that may overlapQ37339406
Generation of influenza A virus NS2 (NEP) mutants with an altered nuclear export signal sequenceQ37492701
Influenza a viruses with mutations in the m1 helix six domain display a wide variety of morphological phenotypesQ37743549
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.Q38287598
Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translationQ38288951
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virusQ39454971
Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathwayQ39601251
Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAsQ39602853
Influenza virus hemagglutinin and neuraminidase glycoproteins stimulate the membrane association of the matrix protein.Q39876368
Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virionsQ40108978
Architecture of ribonucleoprotein complexes in influenza A virus particlesQ40325038
The matrix 1 protein of influenza A virus inhibits the transcriptase activity of a model influenza reporter genome in vivo.Q41008373
An amino acid change in the non-structural NS2 protein of an influenza A virus mutant is responsible for the generation of defective interfering (DI) particles by amplifying DI RNAs and suppressing complementary RNA synthesisQ41500187
Synthesis and cellular location of the ten influenza polypeptides individually expressed by recombinant vaccinia virusesQ43756587
Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinaseQ44539835
NS2/NEP protein regulates transcription and replication of the influenza virus RNA genomeQ45386145
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexesQ45707286
Influenza virus M1 protein binds to RNA through its nuclear localization signalQ45761700
Structure of influenza virus ribonucleoprotein particles. II. Purified RNA-free influenza virus ribonucleoprotein forms structures that are indistinguishable from the intact influenza virus ribonucleoprotein particlesQ45764537
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factorQ45772727
NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cellsQ45856468
Multiple alignment comparison of the non-structural genes of influenza A virusesQ47862435
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectattenuated vaccineQ1810913
influenza A virusQ834390
vaccine engineeringQ14861085
P304page(s)240-248
P577publication date2010-10-21
P1433published inVirus ResearchQ15749215
P1476titleStructure-based design of NS2 mutants for attenuated influenza A virus vaccines
P478volume155

Reverse relations

cites work (P2860)
Q39355418Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
Q30373128Current and emerging cell culture manufacturing technologies for influenza vaccines.
Q30224970Efficacy of live attenuated vaccines against 2009 pandemic H1N1 influenza in ferrets
Q89998096Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine
Q41573715Mutations in the M-gene segment can substantially increase replication efficiency of NS1 deletion influenza A virus in MDCK cells
Q30411859New technologies for influenza vaccines
Q30354239Possibility of cross-species/subtype reassortments in influenza A viruses: an analysis of nonstructural protein variations.
Q26863710Recent progress in structure-based anti-influenza drug design
Q34082989Structure-based vaccines provide protection in a mouse model of ehrlichiosis
Q30424943Vaccine development for protecting swine against influenza virus
Q38148782Vaccines based on structure-based design provide protection against infectious diseases
Q30362529Vaccinia-based influenza vaccine overcomes previously induced immunodominance hierarchy for heterosubtypic protection.

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