Putative roles of purinergic signaling in human immunodeficiency virus-1 infection

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Putative roles of purinergic signaling in human immunodeficiency virus-1 infection is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1041422711
P356DOI10.1186/1745-6150-9-21
P932PMC publication ID4218944
P698PubMed publication ID25351961
P5875ResearchGate publication ID267744907

P50authorPaulo Anastácio Furtado PachecoQ86420148
P2093author name stringIzabel C N P Paixão
Leonardo G B Ferreira
Robson X Faria
P2860cites workHigh levels of HIV-1 in plasma during all stages of infection determined by competitive PCRQ22242246
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channelsQ24533248
Pathogenesis of human immunodeficiency virus infectionQ24634681
Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesQ24651475
Cytopathic Mechanisms of HIV-1Q27485043
Molecular physiology of P2X receptorsQ28203477
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptorsQ28209239
Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activationQ28216646
The birth and postnatal development of purinergic signallingQ28277866
Pharmacological profiles of cloned mammalian P2Y-receptor subtypesQ28279497
Receptors for purines and pyrimidinesQ28283941
Signaling at purinergic P2X receptorsQ28296741
New therapeutic approaches targeted at the late stages of the HIV-1 replication cycleQ28299282
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte deathQ28513626
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusionQ28587109
ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondriaQ28594653
HIV infection is associated with increased NTPDase activity that correlates with CD39-positive lymphocytesQ81606331
Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient miceQ82280464
Experimental and modeling studies of desensitization of P2X3 receptorsQ83181541
Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral γδ cellsQ84254030
Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell cultureQ39439722
Is there a basis for distinguishing two types of P2-purinoceptor?Q39497248
Adenosine 5'-triphosphate is the predominant source of peripheral adenosine in human B lymphoblastsQ39660085
Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells.Q39664323
Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycansQ39823787
Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophagesQ40017700
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophagesQ40355682
Use-dependent inhibition of P2X3 receptors by nanomolar agonist.Q40386589
G protein-coupled P2 purinoceptors: from molecular biology to functional responsesQ40443944
Are second messengers crucial for opening the pore associated with P2X7 receptor?Q40506943
Purinoceptors: are there families of P2X and P2Y purinoceptors?Q40510363
Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphataseQ40518676
Suramin inhibits the in vitro expression of encephalitis B virus proteins NS3 and E.Q40579665
Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP.Q40665495
Benchmarks for antiretroviral therapyQ40716736
Purinergic signalling in the immune system. A brief updateQ40730116
Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activationQ40813156
The inhibition of yellow fever virus multiplication by suramin: a preliminary note.Q40847027
Pore dilation of neuronal P2X receptor channelsQ40960421
The transmitter-gated channels: a range of receptor types and structuresQ41182186
Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptorsQ41203738
Suramin inhibits in vitro infection by duck hepatitis B virus, Rous sarcoma virus, and hepatitis delta virusQ41254783
Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.Q41361630
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-GuérinQ41867941
Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neuronsQ42069973
Regulation of innate immunity by extracellular nucleotidesQ42252932
Autocrine Purinergic Receptor Signaling Is Essential for Macrophage ChemotaxisQ42955253
Activation of the P2X(7) receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophagesQ43125007
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.Q43540455
P2 receptors meet the immune systemQ43549240
The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial deathQ43568198
ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guérin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes.Q43600947
Detection of P2X purinergic receptors on human B lymphocytesQ43632714
ATP stimulates human macrophages to kill intracellular virulent Mycobacterium tuberculosis via calcium-dependent phagosome-lysosome fusionQ43729132
P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability.Q43846494
ATP-induced activation of human B lymphocytes via P2-purinoceptorsQ43923854
Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individualsQ44072580
Prostaglandin E(2) inhibits replication of HIV-1 in macrophages through activation of protein kinase A.Q44079521
Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF-, and chemotactic peptide-induced degranulation in single adherent neutrophilsQ44094639
Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis.Q44545044
A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.Q44649133
P2X7 receptor inhibition improves recovery after spinal cord injuryQ44982503
Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptorQ44982696
Infection of human endothelium in vitro by cytomegalovirus causes enhanced expression of purinergic receptors: a potential virus escape mechanism?Q45398925
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.Q45930388
Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosineQ46217744
Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.Q46338518
ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors.Q51887546
New developments in anti-HIV chemotherapyQ56786460
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptorsQ57731080
Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7ATP ReceptorQ61764030
An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytesQ70884431
Effect of adenosine on the expression of beta(2) integrins and L-selectin of human polymorphonuclear leukocytes in vitroQ71131920
The involvement of an ATP-gated ion channel, P(2X1), in thymocyte apoptosisQ71535990
Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytesQ72037525
Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptorQ73017061
P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical productionQ73303433
Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV diseaseQ73470103
Apoptosis of murine thymocytes induced by extracellular ATP is dose- and cytosolic pH-dependentQ73733767
ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptorsQ73767661
Pharmacologic properties of P(2Z)/P2X(7 )receptor characterized in murine dendritic cells: role on the induction of apoptosisQ74055077
ATP-evoked Ca2+ transients and currents in murine thymocytes: possible role for P2X receptors in death by neglectQ77844730
Expression and function of the purinergic receptor P2X7 in patients with pulmonary tuberculosisQ79224117
A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosisQ79344934
Long-Term suppression of HIV infection: benefits and limitations of current treatment optionsQ79715938
P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathwaysQ80142412
Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthaseQ80564159
A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cellsQ80797764
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an updateQ34701303
HIV-1 replicationQ35016623
Activation and regulation of purinergic P2X receptor channelsQ35122793
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infectionQ35208371
Viral determinants of HIV-1 macrophage tropismQ35593158
Blocking type I interferon production: a new therapeutic option to reduce the HIV-1-induced immune activationQ35606616
Mechanisms of HIV-1 escape from immune responses and antiretroviral drugsQ35832040
The multifactorial nature of HIV-1 latencyQ35935335
Cellular distribution and functions of P2 receptor subtypes in different systemsQ35952737
ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activationQ36232232
Dynamics of ATP-induced calcium signaling in single mouse thymocytesQ36263603
Activation and Desensitization of the Recombinant P2X1 Receptor at Nanomolar ATP ConcentrationsQ36412485
The P2X7 receptor: a key player in IL-1 processing and releaseQ36425273
Purinergic receptors are required for HIV-1 infection of primary human macrophagesQ36429974
P2 receptors: intracellular signalingQ36439708
P2 receptors and immunity.Q36446067
Signal Transduction by P2-Purinergic Receptors for Extracellular ATPQ36640253
Purine and pyrimidine receptorsQ36765468
Dissecting the HIV-specific immune response: a systems biology approachQ36769115
ATP-gated P2X cation-channelsQ37227700
Autocrine regulation of T-cell activation by ATP release and P2X7 receptorsQ37283804
Adenosine: an endogenous modulator of innate immune system with therapeutic potentialQ37493077
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirsQ37615893
Ligand-gated purinergic receptors regulate HIV-1 Tat and morphine related neurotoxicity in primary mouse striatal neuron-glia co-culturesQ37646749
Purinergic signaling: a novel mechanism in immune surveillanceQ37728015
Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infectionQ37852942
Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination.Q37855027
Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected miceQ37859112
Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.Q37868590
Regulation of leukocyte function by adenosine receptorsQ37876538
New approaches for antiviral targeting of HIV assemblyQ37901613
Dynamics of innate immunity are key to chronic immune activation in AIDS.Q37966761
Purinergic signalling: Its unpopular beginning, its acceptance and its exciting futureQ37975129
The sixth sense: hematopoietic stem cells detect danger through purinergic signalingQ38025606
P2X7 receptor regulation of non-classical secretion from immune effector cellsQ38033709
P2X7 receptors: channels, pores and moreQ38042107
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protectionQ30307082
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosisQ30432676
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearanceQ30436506
Modulation of P2Z/P2X(7) receptor activity in macrophages infected with Chlamydia psittaci.Q31715200
Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines.Q33257485
ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophagesQ33351778
IL-1beta processing in host defense: beyond the inflammasomesQ33535878
Dynamic selectivity filters in ion channelsQ33731015
Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virusQ33781062
Extracellular ATP in T-lymphocyte activation: possible role in effector functionsQ33860736
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosisQ34012277
Extracellular ATP in the immune system: more than just a "danger signal".Q34015956
Basal release of ATP: an autocrine-paracrine mechanism for cell regulationQ34020834
Immune cell regulation by autocrine purinergic signallingQ34025783
Cellular function and molecular structure of ecto-nucleotidases.Q34031794
Differential modulation of ATP-induced P2X7-associated permeabilities to cations and anions of macrophages by infection with Leishmania amazonensis.Q34038262
P2Y nucleotide receptors: promise of therapeutic applicationsQ34062142
Host factors and the pathogenesis of HIV-induced diseaseQ34063826
The role of the P2X₇ receptor in infectious diseasesQ34079146
P2 purinergic receptors: modulation of cell function and therapeutic potentialQ34084722
P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.Q34097191
Molecular pharmacology of P2Y-receptorsQ34101812
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapseQ34128014
Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.Q34140085
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile InflammationQ34143696
Molecular physiology of P2X receptors and ATP signalling at synapsesQ34188163
The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectivelyQ34248005
P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infectionQ34261784
P2X7 receptor-stimulation causes fever via PGE2 and IL-1β releaseQ34267097
Nomenclature and classification of purinoceptors.Q34324355
Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infectionQ34355690
Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptorsQ34378750
Nucleotide signalling during inflammationQ34464511
P304page(s)21
P577publication date2014-10-29
P1433published inBiology DirectQ1954915
P1476titlePutative roles of purinergic signaling in human immunodeficiency virus-1 infection
P478volume9

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cites work (P2860)
Q98578557Ca2+ -dependent release of ATP from astrocytes affects herpes simplex virus Type 1 infection of neurons
Q90191907Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion
Q26774666Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation
Q42367885Purinergic Signalling: Therapeutic Developments
Q89037287Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?

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