Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy

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Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy is …
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scholarly articleQ13442814

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P819ADS bibcode2014PNAS..11117266Z
P356DOI10.1073/PNAS.1419599111
P932PMC publication ID4260559
P698PubMed publication ID25411317
P5875ResearchGate publication ID268983943

P50authorBing CuiQ55444983
Samuel H LaiQ90099407
Richard SchwabQ91187033
P2093author name stringChristina C N Wu
Dennis A Carson
George F Widhopf
Thomas J Kipps
Suping Zhang
Rongrong Wu
Liguang Chen
Grace Liu
Emanuela M Ghia
Zhuhong Zhang
P2860cites workCD133 antigen expression in ovarian cancerQ21093306
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancersQ21562662
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinomaQ24308684
Cancer stem cells: problems for therapy?Q37815127
Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancerQ37825148
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular linksQ38007261
ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemiaQ38270729
ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcomeQ39417011
Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesisQ39559733
ALDH enzymatic activity and CD133 positivity and response to chemotherapy in ovarian cancer patientsQ39779683
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cellsQ39932297
The side population of ovarian cancer cells is a primary target of IFN-alpha antitumor effects.Q39960772
Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancerQ40673230
CD133 expression defines a tumor initiating cell population in primary human ovarian cancerQ46789746
Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disordersQ47614258
A gene signature predicting for survival in suboptimally debulked patients with ovarian cancerQ81561698
ROR1 expression is not a unique marker of CLLQ84513968
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5aQ24315721
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Bmi1, stem cells, and senescence regulationQ24614474
Identification and characterization of ovarian cancer-initiating cells from primary human tumorsQ24644329
Cancer stem cells and drug resistance: the potential of nanomedicineQ26998993
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cellsQ28264780
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistanceQ28307294
Ovarian cancer spheroid cells with stem cell-like properties contribute to tumor generation, metastasis and chemotherapy resistance through hypoxia-resistant metabolismQ28538384
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumorsQ29615393
Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan OligosaccharidesQ30478184
Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearanceQ30579225
Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsivenessQ33250633
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcomeQ33359495
Carboplatin and paclitaxel in ovarian carcinoma: a phase I study of the Gynecologic Oncology GroupQ33495949
ROR1 expression correlated with poor clinical outcome in human ovarian cancerQ33942010
Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancerQ34137275
ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growthQ34189274
Self-renewal as a therapeutic target in human colorectal cancer.Q34388958
Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancerQ34420393
Human aldehyde dehydrogenase gene family.Q34459055
Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors.Q34500251
Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.Q34569371
Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosisQ34639023
Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survivalQ35022205
The onco-embryonic antigen ROR1 is expressed by a variety of human cancersQ36433018
Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burdenQ36891437
Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group StudyQ36912591
Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxinQ36983929
New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133).Q37045475
Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.Q37320359
ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic miceQ37495234
Expression of ROR1 in patients with renal cancer--a potential diagnostic marker.Q37522298
Epithelial ovarian cancer: Focus on targeted therapyQ37776846
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
neoplastic stem cellsQ1638475
P304page(s)17266-17271
P577publication date2014-11-19
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOvarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy
P478volume111