The scientific and ethical basis for placebo-controlled trials in depression and schizophrenia: an FDA perspective

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The scientific and ethical basis for placebo-controlled trials in depression and schizophrenia: an FDA perspective is …
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scholarly articleQ13442814

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P356DOI10.1016/S0924-9338(01)00600-9
P698PubMed publication ID11728855

P2093author name stringLaughren TP
P2860cites workThe continuing unethical use of placebo controlsQ28244803
Consistency of atypical antipsychotic superiority to placebo in recent clinical trialsQ31864376
Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration databaseQ33898438
Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depressionQ35180800
Placebo-controlled trials in schizophrenia: are they ethical? Are they necessary?Q53555561
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectplaceboQ269829
research ethicsQ1132684
schizophreniaQ41112
P304page(s)418-423
P577publication date2001-11-01
P1433published inEuropean PsychiatryQ5413047
P1476titleThe scientific and ethical basis for placebo-controlled trials in depression and schizophrenia: an FDA perspective
P478volume16

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cites work (P2860)
Q36489406A 6-week, double-blind, placebo- and haloperidol-controlled, phase II study of lurasidone in patients with acute schizophrenia
Q37014283A renewed, ethical defense of placebo-controlled trials of new treatments for major depression and anxiety disorders
Q24682133Antidepressants and suicide: risk-benefit conundrums
Q35102974Benefits and burdens of placebos in psychiatric research
Q28190011Clinical potential of omega-3 fatty acids in the treatment of schizophrenia
Q49924358Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials.
Q34718444Did regulators fail over selective serotonin reuptake inhibitors?
Q37546125Drugs in development for the treatment of schizophrenia
Q57989648Ethical Issues in the Difference Between Placebo-Controlled and Active-Controlled Trials
Q42558211Ethical and Scientific Perspectives of Placebo-controlled Trials in Schizophrenia
Q37076279Feasibility of reducing the duration of placebo-controlled trials in schizophrenia research
Q91938094Is High Placebo Response Really a Problem in Depression Trials? A Critical Re-analysis of Depression Studies
Q30533987Local IRBs vs. federal agencies: shifting dynamics, systems, and relationships
Q57171759Meta-analysis of Placebo Response in Randomized Clinical Trials of Antipsychotic Drugs Using PANSS Focusing on Different Approaches to the Handling of Missing Data
Q43758906Optimality, sample size, and power calculations for the sequential parallel comparison design
Q43235031Paliperidone palmitate, a potential long-acting treatment for patients with schizophrenia. Results of a randomized, double-blind, placebo-controlled efficacy and safety study
Q42646762Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder
Q26776255Rethinking psychopharmacotherapy: The role of treatment context and brain plasticity in antidepressant and antipsychotic interventions
Q24241041Risperidone versus placebo for schizophrenia
Q24243436Risperidone versus placebo for schizophrenia
Q55894951Risperidone versus placebo for schizophrenia
Q31057535Safety of research into severe and treatment-resistant mood disorders: analysis of outcome data from 12 years of clinical trials at the US National Institute of Mental Health
Q44606674Selective Serotonin Reuptake Inhibitors and Suicide: Is the Evidence, as with Beauty, in the Eye of the Beholder?
Q36582016Should desperate volunteers be included in randomised controlled trials?
Q26773320Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports
Q42931074The Use of Placebo-Controlled Clinical Trials for the Approval of Psychiatric Drugs: Part II-Ethical Considerations Related to the Individual Participant
Q38040453The argument of antidepressant drugs in the treatment of bipolar depression: mixed evidence or mixed states?
Q33956817The investigator and the IRB: a survey of depression and schizophrenia researchers
Q35102476The new and evolving pharmacotherapy of schizophrenia
Q41909209The use of placebo-controlled clinical trials for the approval of psychiatric drugs: part I-statistics and the case for the "greater good".
Q41411828Time to abandon placebo control in pivotal phase III trials?
Q85097129Trial design issues and treatment effect modeling in multi‐regional schizophrenia trials

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