Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease

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Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease is …
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scholarly articleQ13442814

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P356DOI10.18632/ONCOSCIENCE.64
P932PMC publication ID4278314
P698PubMed publication ID25594051
P5875ResearchGate publication ID266731652

P2093author name stringErica A Golemis
Emmanuelle Nicolas
Tim N Beck
Meghan C Kopp
P2860cites workDirect interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1Q21284174
Overexpression of s6 kinase 1 in brain tumours is associated with induction of hypoxia-responsive genes and predicts patients' survivalQ21296638
NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migrationQ21561000
Tau interacts with src-family non-receptor tyrosine kinasesQ22003901
Cancer genome landscapesQ22242276
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer diseaseQ22248076
Alzheimer's DiseaseQ22248111
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Variant of TREM2 Associated with the Risk of Alzheimer's DiseaseQ22250874
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseQ22251067
Alzheimer mechanisms and therapeutic strategiesQ22252311
Tau pathology in Alzheimer disease and other tauopathiesQ22252520
Appraising the brain's energy budgetQ22337193
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functionsQ24307776
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activationQ24312845
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesQ24316242
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseQ24316501
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cellsQ24317734
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiaeQ24323041
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substratesQ24324381
The docking protein HEF1 is an apoptotic mediator at focal adhesion sitesQ24553123
A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1Q24595443
CAS proteins in normal and pathological cell growth controlQ24630247
HEF1-dependent Aurora A activation induces disassembly of the primary ciliumQ24647111
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9Q24656693
Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingQ24669865
Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytesQ24676931
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Calcium signaling and amyloid toxicity in Alzheimer diseaseQ33799937
Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cellsQ33809899
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RAFTK/Pyk2-mediated cellular signallingQ33855347
Current status on Alzheimer disease molecular genetics: from past, to present, to futureQ33871345
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Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytesQ33955205
Aggregation of vascular risk factors and risk of incident Alzheimer diseaseQ33989502
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Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's diseaseQ34016371
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The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.Q34138871
Targeting Pyk2 for therapeutic interventionQ34146883
The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.Q34169212
Rapid calcium-dependent activation of Aurora-A kinase.Q34239225
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancerQ34295621
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomersQ34396204
The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1.Q34434204
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.Q34537154
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neuronsQ34590202
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.Q34748737
Aurora A kinase activity influences calcium signaling in kidney cellsQ35047469
The acetylation of tau inhibits its function and promotes pathological tau aggregationQ35059866
Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell linesQ35093687
Extended results of the Alzheimer's disease anti-inflammatory prevention trialQ35146385
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidneyQ35215135
Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infectionQ35640945
Presenilins and γ-secretase: structure, function, and role in Alzheimer DiseaseQ35658184
Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injuryQ35744840
Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapyQ35882137
Genome-wide association study of primary open angle glaucoma risk and quantitative traitsQ35957011
Angiotensin II revisited: new roles in inflammation, immunology and agingQ36039299
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamateQ33596829
ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.Q33652534
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy modelQ33715257
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Q33751705
Protein tyrosine kinase 2beta as a candidate gene for hypertensionQ46854007
Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicityQ46920848
Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trialQ47343172
Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam StudyQ47790444
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's diseaseQ48181387
A new paradigm for the treatment of Alzheimer's disease: targeting vascular activation.Q50690290
NEDD9 gene polymorphism influences the risk of Alzheimer disease and cognitive function in Chinese older persons.Q51809705
Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study.Q52061053
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.Q52200995
Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation.Q52538801
Mutations in TREM2 lead to pure early-onset dementia without bone cysts.Q52587424
Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.Q53155938
Predisposing locus for Alzheimer's disease on chromosome 21.Q53187559
Association of incident Alzheimer disease and blood pressure measured from 13 years before to 2 years after diagnosis in a large community study.Q53349055
Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging.Q53354093
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension.Q54378215
Renal-Cell CarcinomaQ56019528
Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association StudyQ57605743
Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathyQ58477361
Genetics of Alzheimer's diseaseQ58920538
Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older personsQ73115038
Role of calcium-sensitive tyrosine kinase Pyk2/CAKbeta/RAFTK in angiotensin II induced Ras/ERK signalingQ77418880
Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscleQ77426358
Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cellsQ81656234
Inflammation and Alzheimer's diseaseQ82323473
Renal cell carcinomaQ82656838
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability,Q83608958
US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008Q84300422
The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensionsQ40340844
VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cellsQ40373217
The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.Q40407170
Phosphorylation of tau by fyn: implications for Alzheimer's disease.Q40582507
Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclastsQ40704233
Human endothelial Pyk2 is expressed in two isoforms and associates with paxillin and p130CasQ40753563
Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK.Q40771561
Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteinsQ40977784
Mechanisms of neuronal degeneration in Alzheimer's diseaseQ40986730
T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.Q41094192
Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase SubfamilyQ41296563
Role of NEDD9 in invasion and metastasis of lung adenocarcinomaQ41323971
Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regionsQ41880646
The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensisQ41957932
It cuts two ways: microtubule loss during Alzheimer diseaseQ41972657
Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscleQ42515619
Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?Q42659546
Effect of angiotensin II type 2 receptor on tyrosine kinase Pyk2 and c-Jun NH2-terminal kinase via SHP-1 tyrosine phosphatase activity: evidence from vascular-targeted transgenic mice of AT2 receptorQ43575289
CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.Q43615463
Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementiaQ43668225
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylationQ43688548
Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging studyQ43820251
The combined impact of 12 common variants on hypertension in Japanese men, considering GWAS resultsQ44096786
Abeta(25-35) and Abeta(1-40) act on different calcium channels in CA1 hippocampal neuronsQ44122940
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's diseaseQ44191043
Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humansQ44504448
The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motilityQ44929670
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptorsQ45092703
Overexpression of NEDD9 is associated with altered expression of E-Cadherin, β-Catenin and N-Cadherin and predictive of poor prognosis in non-small cell lung cancerQ46625804
Disease-related modifications in tau affect the interaction between Fyn and Tau.Q46663739
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophagesQ46847122
Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cellsQ28281337
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cellsQ28281874
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapyQ28282855
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependentQ28283260
Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's diseaseQ28285170
VHL inactivation induces HEF1 and Aurora kinase AQ28294037
NEDD9 is genetically associated with Alzheimer's disease in a Han Chinese populationQ28297844
Integrin signalling adaptors: not only figurants in the cancer storyQ28299126
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistanceQ28304848
The optimal use of bexarotene in cutaneous T-cell lymphomaQ28305252
Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cellsQ28577298
Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrinsQ28582208
Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cellsQ28582472
Divergent regulation of Pyk2/CAKbeta phosphorylation by Ca2+ and cAMP in the hippocampusQ28583379
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamicsQ28585404
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitmentQ28587157
Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular functionQ28594535
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's diseaseQ28742427
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasQ29030077
Genome-wide association study of Alzheimer's diseaseQ29417071
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's diseaseQ29417137
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspectiveQ29614702
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseQ29614881
Focal adhesion kinase: in command and control of cell motilityQ29615192
A general framework for estimating the relative pathogenicity of human genetic variantsQ29615730
Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathwayQ30168046
c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPaseQ30168758
Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylationQ30168812
Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study.Q30410885
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.Q30472274
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypesQ30530899
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1Q30537824
Human-specific transcriptional networks in the brainQ30539579
Glaucoma is associated with peripheral vascular endothelial dysfunction.Q30839295
The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamicsQ33554597
Primary cilia in the developing and mature brainQ27002324
The pathobiology of vascular dementiaQ27006033
Late-Onset Alzheimer's Disease Genes and the Potentially Implicated PathwaysQ27014964
NSP-Cas protein structures reveal a promiscuous interaction module in cell signalingQ27675552
Comprehensive molecular characterization of clear cell renal cell carcinomaQ27852374
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signallingQ28142155
Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinaseQ28142663
Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascadesQ28144135
Identification of a set of genes with developmentally down-regulated expression in the mouse brainQ28187594
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]Q28212545
Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleQ28241105
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundleQ28242010
CAS proteins in health and disease: an updateQ28242737
Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling componentQ28251271
BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with CrklQ28257171
Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7Q28257757
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's diseaseQ28260161
Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cellsQ28263643
T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3GQ28264262
A novel Cas family member, HEPL, regulates FAK and cell spreadingQ28267647
Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissuesQ28269124
HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cellsQ28270184
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosomeQ28273944
NEDD9 rs760678 polymorphism and the risk of Alzheimer's disease: a meta-analysisQ28274763
Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemiaQ28275942
Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancerQ28276415
All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryosQ28277857
The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell traffickingQ28279398
Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's diseaseQ28280937
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the CytoskeletonQ28281154
Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosisQ36091819
Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogeneticsQ36402212
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditionsQ36835522
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.Q36890122
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's diseaseQ36914722
The GSK3 hypothesis of Alzheimer's diseaseQ37035378
The aurora kinase A regulates GSK-3beta in gastric cancer cellsQ37096754
Animal models of Alzheimer's disease and frontotemporal dementiaQ37196122
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive personsQ37196206
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathwaysQ37267214
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.Q37288448
Tau phosphorylation: the therapeutic challenge for neurodegenerative diseaseQ37402114
Microtubule assembly, organization and dynamics in axons and dendritesQ37450792
Biomarker modeling of Alzheimer's diseaseQ37592824
Hypoxia and neurodegenerationQ37618864
Emerging roles of Wnts in the adult nervous systemQ37654778
FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumorsQ37707278
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancerQ37750751
Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?Q37799220
The genetics of Alzheimer disease: back to the futureQ37801081
Psychotropic drug effects on gene transcriptomics relevant to Alzheimer diseaseQ37852542
Amyloid precursor protein processing and Alzheimer's diseaseQ37860317
Does vascular pathology contribute to Alzheimer changes?Q38033859
Alzheimer's disease: an update of the roles of receptors, astrocytes and primary cilia (review).Q38057662
Key developments in renin-angiotensin-aldosterone system inhibition.Q38061004
Primary cilia in neurodevelopmental disordersQ38168054
Review: The genetics of Alzheimer's disease; putting flesh on the bonesQ38180149
Glial calcium signalling in Alzheimer's disease.Q38220737
Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinaseQ38311339
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatumQ38344063
NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastomaQ39043526
Retinoic acid induces adhesion and migration in NB4 cells through Pyk2 signalingQ39166207
TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.Q39702429
Identification of genes that regulate epithelial cell migration using an siRNA screening approachQ39892281
atRA Regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesionQ39967404
P433issue7
P921main subjectAlzheimer's diseaseQ11081
P304page(s)486-503
P577publication date2014-07-23
P1433published inOncoscienceQ27725796
P1476titleAdaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease
P478volume1

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